An Increase in Group B Invasive Meningococcal Disease Among Adolescents and Young Adults in England Following Easing of COVID-19 Containment Measures

2021 ◽  
Author(s):  
Stephen Clark ◽  
Helen Campbell ◽  
Anna A. Mensah ◽  
Aiswarya Lekshmi ◽  
Andrew Walker ◽  
...  
Keyword(s):  
Young Adults ◽  
Meningococcal Disease ◽  
Adolescents And Young Adults ◽  
Invasive Meningococcal Disease ◽  
Containment Measures ◽  
Group B

Epidemiological Characteristics of Meningococcal Infection in Moscow

2020 ◽  
Vol 19 (2) ◽  
pp. 56-62
Author(s):  
M. I. Gritsay ◽  
M. A. Koroleva ◽  
N. N. Fomkina ◽  
I. S. Koroleva
Keyword(s):  
Young Adults ◽  
Mortality Rate ◽  
Incidence Rate ◽  
Meningococcal Disease ◽  
Invasive Meningococcal Disease ◽  
Meningococcal Infection ◽  
Epidemic Process ◽  
Epidemiological Features ◽  
Teenagers And Young Adults ◽  
Epidemiological Characteristics

Aims. The purpose of this study was to identify current epidemiological features of meningococcal infection in Moscow.Materials and methods. Cases of invasive meningococcal disease in Moscow from 2014 to 2018 and the biomaterial from patients with an invasive meningococcal disease were analyzed.Results. The features of the epidemic process of meningococcal disease in Moscow were revealed: increasing in the incidence rate involving teenagers and young adults into the epidemic process; meningococcal strains of serogroups W and A increased in the etiology of the invasive meningococcal disease; high mortality rate.Conclusions. It seems reasonable to recommend vaccination against meningococcal disease by including adolescents, young adults and persons over 65 years old.

scholarly journals Meningococcal Group B Vaccine For The Prevention Of Invasive Meningococcal Disease Caused By Neisseria meningitidis Serogroup B

2019 ◽  
Vol Volume 12 ◽  
pp. 3169-3188 ◽  
Author(s):  
Irene Rivero-Calle ◽  
Peter Francis Raguindin ◽  
Jose Gómez-Rial ◽  
Carmen Rodriguez-Tenreiro ◽  
Federico Martinón-Torres
Keyword(s):  
Neisseria Meningitidis ◽  
Meningococcal Disease ◽  
Invasive Meningococcal Disease ◽  
Meningococcal Group ◽  
Group B

scholarly journals Potential Capsule Switching from Serogroup Y to B: The Characterization of Three suchNeisseria meningitidisIsolates Causing Invasive Meningococcal Disease in Canada

2005 ◽  
Vol 16 (3) ◽  
pp. 171-174 ◽  
Author(s):  
Raymond SW Tsang ◽  
Dennis KS Law ◽  
Shaun D Tyler ◽  
Gwen S Stephens ◽  
Mark Bigham ◽  
...  
Keyword(s):  
Neisseria Meningitidis ◽  
Meningococcal Disease ◽  
Multilocus Sequence Typing ◽  
Housekeeping Gene ◽  
Sequence Type ◽  
Invasive Meningococcal Disease ◽  
Group B

Three group BNeisseria meningitidisisolates, recovered from meningococcal disease cases in Canada and typed as B:2c:P1.5, were characterized. Multilocus sequence typing showed that all three isolates were related because of an identical sequence type (ST) 573. Isolates typed as 2c:P1.5 are common in serogroup Y meningococci but rare in isolates from serogroups B or C. Although no serogroup Y isolates have been typed as ST-573, eight isolates showed five to six housekeeping gene alleles that were identical to that of ST-573. This suggested that the B:2c:P1.5 isolates may have originated from serogroup Y organisms, possibly by capsule switching.

scholarly journals First case of interconnected clusters of primary meningococcal arthritis and meningococcal meningitis due to Neisseria meningitidis serogroup B in Slovenia

2021 ◽  
pp. 1-9
Author(s):  
Miha Simoniti ◽  
Tanja Selič Kurinčič ◽  
Alenka Trop Skaza ◽  
Ines Kebler ◽  
Metka Paragi ◽  
...  
Keyword(s):  
Young Adults ◽  
Septic Arthritis ◽  
Neisseria Meningitidis ◽  
General Hospital ◽  
Meningococcal Disease ◽  
Meningococcal Meningitis ◽  
Invasive Meningococcal Disease ◽  
First Case ◽  
The Right

In this report, we describe a case of interconnected clusters of invasive meningococcal disease due to Neisseria meningitidis serogroup B:P1.22,14:F5-1(ST-269) in young adults – a boyfriend and a girlfriend. The male was diagnosed with primary meningococcal septic arthritis of the right knee and the female was diagnosed with meningococcal meningitis with meningococcemia a few hours later. Both were hospitalized at the General Hospital Celje and treated with ceftriaxone, but with different outcomes; the female recovered completely, while the male will probably have long-term sequelae of septic arthritis.

scholarly journals 2455. Is Category B Working? Uptake Patterns of Meningococcal Group B Vaccine Among US Adolescents and Young Adults

2018 ◽  
Vol 5 (suppl_1) ◽  
pp. S735-S735
Author(s):  
Farid L Khan ◽  
David L Swerdlow ◽  
Laura J York ◽  
Paul Balmer ◽  
Raul E Isturiz ◽  
...  
Keyword(s):  
Young Adults ◽  
Adolescents And Young Adults ◽  
Meningococcal Group ◽  
Group B

scholarly journals AMEND study protocol: a case–control study to assess the long-term impact of invasive meningococcal disease in Australian adolescents and young adults

BMJ Open ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. e032583
Author(s):  
Helen Marshall ◽  
Mark McMillan ◽  
Bing Wang ◽  
Robert Booy ◽  
Hossein Afzali ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Young Adults ◽  
Outcome Measures ◽  
Meningococcal Disease ◽  
Case Control Study ◽  
Case Control ◽  
Invasive Meningococcal Disease ◽  
Control Study

IntroductionInvasive meningococcal disease (IMD) primarily causes disease in young children and adolescents and can cause long-term disability. Many countries are considering implementation of meningococcal B and/or meningococcal ACWY vaccines to control meningococcal disease. Estimating the cost-effectiveness of meningococcal vaccine programme is hampered due to a lack of good quality costing and burden of disease data. This study aims to address this evidence gap by assessing the clinical, physical, neurocognitive, economic and societal impact of IMD on adolescents and young adults.Methods and analysisA case–control study of 64 participants with confirmed IMD (15–24 years 11 months at time of disease) and 64 control participants (17–34 years 11 months) will be conducted in Australia from 2016 to 2020. All participants will undergo a neurocognitive assessment, full medical examination, pure tone audiometry assessment and complete quality of life and behavioural questionnaires. Meningococcal cases will be assessed 2–10 years posthospitalisation and a subset of cases will be interviewed to explore in depth their experiences of IMD and its impact on their life. Primary outcome measures include general intellectual functioning from the Wechsler Adult Intelligence Scale and overall quality of life from the Health Utilities Index. Secondary outcome measures include academic achievement, executive functioning, behaviour, hearing, psychological and physical functioning. Outcome measures will be compared between cases and controls using independent t-tests or ORs, or if any significant confounders are identified, adjusted analyses (analysis of covariance or adjusted ORs) will be conducted. Thematic analysis will be used to analyse transcribed interviews and a costing model will be used to project lifetime costs.Ethics and disseminationThe Adolescent MENingococcal Disease (AMEND) study has been approved by the Human Research Ethics Committee of the Women’s and Children’s Health Network (HREC/14/WCHN/024). The results will be disseminated via peer-reviewed publications, conference presentations, study participants, and meningococcal and meningitis foundations.Trial registration numberNCT03798574.

Invasive meningococcal disease in children in Ireland, 2001–2011

2016 ◽  
Vol 101 (12) ◽  
pp. 1125-1129 ◽  
Author(s):  
Cilian Ó Maoldomhnaigh ◽  
Richard J Drew ◽  
Patrick Gavin ◽  
Mary Cafferkey ◽  
Karina M Butler
Keyword(s):  
Meningococcal Disease ◽  
Clinical Presentation ◽  
Assessment Tool ◽  
Vaccination Campaign ◽  
Invasive Meningococcal Disease ◽  
Historical Cohort ◽  
Vaccine Introduction ◽  
Group B ◽  
Study Hospital ◽  
Paediatric Intensive Care Units

BackgroundIn 1999, invasive meningococcal disease was hyperendemic in Ireland at 14.75/100 000 population, with 60% group B and 30% group C diseases. National sepsis guidelines and meningococcal C vaccines were introduced in 2000. Despite a spontaneous decline in group B infection, invasive meningococcal disease remains a leading cause of sepsis. This study characterises the epidemiology of invasive meningococcal disease in children in Ireland since the introduction of meningococcal C vaccine and reviews its clinical presentation, hospital course and outcome in anticipation of meningococcal B vaccine introduction.MethodsNational surveillance data were obtained from the Health Protection Surveillance Centre. A retrospective study of all meningococcal cases at two tertiary paediatric hospitals was conducted from 2001 to 2011. Records were reviewed using a standardised assessment tool. A study of 407 meningococcal cases published in 2002 provided comparative data.ResultsOf 1820 cases <19 years of age notified nationally, 382 (21%) cases attended a study hospital; 94% group B, 3% group C, 225 (59%) male, median age 5 years (range 0.1–18). Fever was absent at presentation in 18%. Fifteen patients (3.6%) died. 221 (61%) were admitted to paediatric intensive care units (PICU). Permanent sequelae occurred in 9.4%. Compared with the historical cohort, there were differences in presentation, an increase in PICU interventions, but no significant decline in morbidity or mortality.ConclusionsDespite the meningococcal C vaccination campaign, invasive meningococcal disease continues to cause serious morbidity and claim lives. Group B infections remain dominant. As children who die often present with fulminant disease, preventive strategies including use of meningococcal B vaccine are needed to avert death and sequelae.

scholarly journals Invasive Meningococcal Disease in Scotland, 1994 to 1999, with Emphasis on Group B Meningococcal Disease

2002 ◽  
Vol 40 (5) ◽  
pp. 1834-1837 ◽  
Author(s):  
M. H. Kyaw ◽  
S. C. Clarke ◽  
P. Christie ◽  
I. G. Jones ◽  
H. Campbell
Keyword(s):  
Meningococcal Disease ◽  
Invasive Meningococcal Disease ◽  
Group B
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