New Insights on Metal Ions Accelerating the Aging Behavior of Polystyrene Microplastics: Effects of Different Excess Reactive Oxygen Species

2021 ◽  
Author(s):  
Xiaoqin Yu ◽  
Yibo Xu ◽  
Mengfan Lang ◽  
Daofen Huang ◽  
Lingyan Zhu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Metal Ions ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Aging Behavior ◽  
Excess Reactive Oxygen Species

Amentoflavone: A Bifunctional Metal Chelator that Controls the Formation of Neurotoxic Soluble Aβ42 Oligomers

2020 ◽  
Author(s):  
Liang Sun ◽  
Anuj K. Sharma ◽  
Byung-Hee Han ◽  
Liviu M. Mirica
Keyword(s):  
Reactive Oxygen Species ◽  
Metal Ions ◽  
Antioxidant Properties ◽  
Reactive Oxygen ◽  
Amyloid Plaques ◽  
Transition Metal Ions ◽  
Oxygen Species ◽  
High Affinity ◽  
Amyloid Aβ ◽  
Β Amyloid

<p>Alzheimer's disease (AD) is the most common neurodegenerative disorder, yet the cause and progression of this disorder are not completely understood. While the main hallmark of AD is the deposition of amyloid plaques consisting of the β-amyloid (Aβ) peptide, transition metal ions are also known to play a significant role in disease pathology by expediting the formation of neurotoxic soluble β-amyloid (Aβ) oligomers, reactive oxygen species (ROS), and oxidative stress. Thus, bifunctional metal chelators that can control these deleterious properties are highly desirable. Herein, we show that amentoflavone (AMF) – a natural biflavonoid compound, exhibits good metal-chelating properties, especially for chelating Cu<sup>2+</sup> with very high affinity (pCu<sub>7.4</sub> = 10.44). In addition, AMF binds to Aβ fibrils with a high affinity (<i>K<sub>i</sub></i> = 287 ± 20 nM) – as revealed by a competition thioflavin T (ThT) assay, and specifically labels the amyloid plaques <i>ex vivo</i> in the brain sections of transgenic AD mice – as confirmed via immunostaining with an Ab antibody. The effect of AMF on Aβ<sub>42</sub> aggregation and disaggregation of Aβ<sub>42</sub> fibrils was also investigated, to reveal that AMF can control the formation of neurotoxic soluble Aβ<sub>42</sub> oligomers, both in absence and presence of metal ions, and as confirmed via cell toxicity studies. Furthermore, an ascorbate consumption assay shows that AMF exhibits potent antioxidant properties and can chelate Cu<sup>2+</sup> and significantly diminish the Cu<sup>2+</sup>-ascorbate redox cycling and reactive oxygen species (ROS) formation. Overall, these studies strongly suggest that AMF acts as a bifunctional chelator that can interact with various Aβ aggregates and reduce their neurotoxicity, can also bind Cu<sup>2+</sup> and mediate its deleterious redox properties, and thus AMF has the potential to be a lead compound for further therapeutic agent development for AD. </p>

High Glucose Level Induces Cardiovascular Dysplasia During Early Embryo Development

2017 ◽  
Vol 127 (09) ◽  
pp. 590-597
Author(s):  
Yi-mei Jin ◽  
Shu-zhu Zhao ◽  
Zhao-long Zhang ◽  
Yao Chen ◽  
Xin Cheng ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Reactive Oxygen Species ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
High Glucose ◽  
Reactive Oxygen ◽  
Early Embryo ◽  
Yolk Sac ◽  
Oxygen Species ◽  
Excess Reactive Oxygen Species

AbstractThe incidence of gestational diabetes mellitus (GDM) has increased dramatically amongst multiethnic population. However, how gestational diabetes mellitus damages the developing embryo is still unknown. In this study, we used yolk sac membrane (YSM) model to investigate angiogenesis in the developing chick embryo. We determined that in the presence of high glucose, it retarded the growth and extension of the embryonic vascular plexus and it also reduced the density of the vasculature in yolk sac membrane model. Using the same strategy, we used the chorioallantoic membrane (CAM) as a model to investigate the influence of high glucose on the vasculature. We established that high glucose inhibited development of the blood vessel plexus and the blood vessels formed had a narrower diameter than control vessels. Concurrent with the abnormal angiogenesis, we also examined how it impacted cardiogenesis. We determined the myocardium in the right ventricle and left atrium were significantly thicker than the control and also there was a reduction in glycogen content in cardiomyocytes. The high glucose also induced excess reactive oxygen species (ROS) production in the cardiomyocytes. We postulated that it was the excess reactive oxygen species that damaged the cardiomyocytes resulting in cardiac hyperplasia.

Recent advances in semiconducting polymer dots as optical probes for biosensing

2021 ◽  
Author(s):  
Ye Yuan ◽  
Weiying Hou ◽  
Weiping Qin ◽  
Changfeng Wu
Keyword(s):  
Reactive Oxygen Species ◽  
Metal Ions ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Optical Probes ◽  
Semiconducting Polymer ◽  
Ph Values ◽  
Recent Advances ◽  
Polymer Dots ◽  
Semiconducting Polymer Dots

This review mainly summarized the recent results that used bright polymer dots (Pdots) for the detection of different analytes such as reactive oxygen species (ROS), metal ions, pH values, and a variety of biomolecules.

scholarly journals Generation of Reactive Oxygen Species by Interaction between Antioxidants Used as Food Additive and Metal Ions

2014 ◽  
Vol 55 (4) ◽  
pp. 167-176 ◽  
Author(s):  
Yusuke IWASAKI ◽  
Momoko ODA ◽  
Yuri TSUKUDA ◽  
Yuki NAGAMORI ◽  
Hiroyuki NAKAZAWA ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Metal Ions ◽  
Reactive Oxygen ◽  
Food Additive ◽  
Oxygen Species

Fluorescent and Colorimetric Chemosensors for Anions, Metal Ions, Reactive Oxygen Species, Biothiols, and Gases

2016 ◽  
Vol 37 (10) ◽  
pp. 1661-1678 ◽  
Author(s):  
Yifan Liu ◽  
Ying Hu ◽  
Songyi Lee ◽  
Dayoung Lee ◽  
Juyoung Yoon
Keyword(s):  
Reactive Oxygen Species ◽  
Metal Ions ◽  
Reactive Oxygen ◽  
Oxygen Species

Methylmercury cytotoxicity in PC12 cells is mediated by primary glutathione depletion independent of excess reactive oxygen species generation

Toxicology ◽  
2004 ◽  
Vol 204 (2-3) ◽  
pp. 175-185 ◽  
Author(s):  
Rita Gatti ◽  
Silvana Belletti ◽  
Jacopo Uggeri ◽  
Maria Vittoria Vettori ◽  
Antonio Mutti ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Pc12 Cells ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Glutathione Depletion ◽  
Oxygen Species ◽  
Excess Reactive Oxygen Species
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