Injectable Double Network Hydrogel with Hemostasis and Antibacterial Activity for Promoting Multidrug−Resistant Bacteria Infected Wound Healing

2021 ◽  
Author(s):  
Zibo Zhang ◽  
Jiadong Guo ◽  
Yuxiang He ◽  
Zhifeng Zou ◽  
Jinzhi Han ◽  
...  
Keyword(s):  
Wound Healing ◽  
Antibacterial Activity ◽  
Multidrug Resistant ◽  
Resistant Bacteria ◽  
Infected Wound ◽  
Multidrug Resistant Bacteria ◽  
Double Network

Polysaccharide‐Peptide Cryogels for Multidrug‐Resistant‐Bacteria Infected Wound Healing and Hemostasis

2019 ◽  
Vol 9 (3) ◽  
pp. 1901041 ◽  
Author(s):  
Sen Hou ◽  
Yuanyuan Liu ◽  
Fang Feng ◽  
Jin Zhou ◽  
Xinxing Feng ◽  
...  
Keyword(s):  
Wound Healing ◽  
Multidrug Resistant ◽  
Resistant Bacteria ◽  
Infected Wound ◽  
Multidrug Resistant Bacteria

scholarly journals The Antibacterial Activity of Human Amniotic Membrane against Multidrug-Resistant Bacteria Associated with Urinary Tract Infections: New Insights from Normal and Cancerous Urothelial Models

Biomedicines ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 218
Author(s):  
Taja Železnik Ramuta ◽  
Larisa Tratnjek ◽  
Aleksandar Janev ◽  
Katja Seme ◽  
Marjanca Starčič Erjavec ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Amniotic Membrane ◽  
Multidrug Resistant ◽  
Basic Knowledge ◽  
Resistant Bacteria ◽  
Human Amniotic Membrane ◽  
Multidrug Resistant Bacteria ◽  
Tract Infections

Urinary tract infections (UTIs) represent a serious global health issue, especially due to emerging multidrug-resistant UTI-causing bacteria. Recently, we showed that the human amniotic membrane (hAM) could be a candidate for treatments and prevention of UPEC and Staphylococcus aureus infections. However, its role against multidrug-resistant bacteria, namely methicillin-resistant S. aureus (MRSA), extended-spectrum beta-lactamases (ESBL) producing Escherichia coli and Klebsiella pneumoniae, vancomycin-resistant Enterococci (VRE), carbapenem-resistant Acinetobacter baumannii, and Pseudomonas aeruginosa has not yet been thoroughly explored. Here, we demonstrate for the first time that the hAM homogenate had antibacterial activity against 7 out of 11 tested multidrug-resistant strains, the greatest effect was on MRSA. Using novel approaches, its activity against MRSA was further evaluated in a complex microenvironment of normal and cancerous urinary bladder urothelia. Even short-term incubation in hAM homogenate significantly decreased the number of bacteria in MRSA-infected urothelial models, while it did not affect the viability, number, and ultrastructure of urothelial cells. The hAM patches had no antibacterial activity against any of the tested strains, which further exposes the importance of the hAM preparation. Our study substantially contributes to basic knowledge on the antibacterial activity of hAM and reveals its potential to be used as an antibacterial agent against multidrug-resistant bacteria.

Stalobacin: Discovery of Novel Lipopeptide Antibiotics with Potent Antibacterial Activity against Multidrug-Resistant Bacteria

2020 ◽  
Vol 63 (11) ◽  
pp. 6090-6095 ◽  
Author(s):  
Kouhei Matsui ◽  
Yukiko Kan ◽  
Junko Kikuchi ◽  
Keisuke Matsushima ◽  
Miki Takemura ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Multidrug Resistant ◽  
Resistant Bacteria ◽  
Multidrug Resistant Bacteria ◽  
Lipopeptide Antibiotics

scholarly journals Antibacterial Activity of the Non-Cytotoxic Peptide (p-BthTX-I)2 and Its Serum Degradation Product against Multidrug-Resistant Bacteria

Molecules ◽  
2017 ◽  
Vol 22 (11) ◽  
pp. 1898 ◽  
Author(s):  
Norival Santos-Filho ◽  
Rafaela Fernandes ◽  
Bruna Sgardioli ◽  
Matheus Ramos ◽  
Julia Piccoli ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Degradation Product ◽  
Multidrug Resistant ◽  
Resistant Bacteria ◽  
Multidrug Resistant Bacteria ◽  
Cytotoxic Peptide

Antibacterial activity of Limonium brasiliense (Baicuru) against multidrug-resistant bacteria using a statistical mixture design

2017 ◽  
Vol 198 ◽  
pp. 313-323 ◽  
Author(s):  
Andressa Blainski ◽  
Barbara Gionco ◽  
Admilton G. Oliveira ◽  
Galdino Andrade ◽  
Ieda S. Scarminio ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Multidrug Resistant ◽  
Mixture Design ◽  
Resistant Bacteria ◽  
Multidrug Resistant Bacteria ◽  
Statistical Mixture
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