Melatonin Regulates the Circadian Rhythm to Ameliorate Postoperative Sleep Disorder and Neurobehavioral Abnormalities in Aged Mice

2021 ◽  
Author(s):  
Xixi Jia ◽  
Yanan Song ◽  
Zhengqian Li ◽  
Ning Yang ◽  
Taotao Liu ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Sleep Disorder ◽  
Aged Mice

Circadian rhythm resynchronization improved isoflurane-induced cognitive dysfunction in aged mice

2018 ◽  
Vol 306 ◽  
pp. 45-54 ◽  
Author(s):  
Jia Song ◽  
Shuaishuai Chu ◽  
Yin Cui ◽  
Yue Qian ◽  
Xiuxiu Li ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Cognitive Dysfunction ◽  
Aged Mice

New uses of Melatonin as a Drug, a Review

2022 ◽  
Vol 29 ◽  
Author(s):  
Miroslav Pohanka
Keyword(s):  
Cell Cycle ◽  
Circadian Rhythm ◽  
Sleep Disorder ◽  
Neurodegenerative Disorders ◽  
Melatonin Receptors ◽  
The Other ◽  
Basic Facts ◽  
Regulation Of Cell Cycle ◽  
Lifestyle Diseases

Abstract: Melatonin is a simple compound with a proper chemical name N-acetyl-5-methoxy tryptamine and known as a hormone controlling circadian rhythm. Humans produce melatonin at night which is the reason for sleeping in the night and awakening over the day. Melatonin interacts with melatonin receptors MT1 and MT2 but it was also revealed that melatonin is a strong antioxidant and it also has a role in regulation of cell cycle. Currently, melatonin is used as a drug for some types of sleep disorder but the recent research points to the fact that melatonin can also serve for the other purposes including prophylaxis or therapy of lifestyle diseases, cancer, neurodegenerative disorders and exposure to chemicals. This review summarizes basic facts and direction of the current research on melatonin. The actual literature was scrutinized for the purpose of this review.

scholarly journals Circadian Rhythm Sleep Disorder: Irregular Sleep Wake Rhythm

2009 ◽  
Vol 4 (2) ◽  
pp. 213-218 ◽  
Author(s):  
Phyllis C. Zee ◽  
Michael V. Vitiello
Keyword(s):  
Circadian Rhythm ◽  
Sleep Disorder ◽  
Circadian Rhythm Sleep Disorder

scholarly journals Circadian Sleep Regulation in the Absence of Light Perception: Chronic Non-24-Hour Circadian Rhythm Sleep Disorder in a Blind Man With a Regular 24-Hour Sleep—Wake Schedule

SLEEP ◽  
1993 ◽  
Vol 16 (4) ◽  
pp. 333-343 ◽  
Author(s):  
Torsten Klein ◽  
Heinz Martens ◽  
Derk-Jan Dijk ◽  
Richard E. Kronauer ◽  
Ellen W. Seely ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Sleep Disorder ◽  
Light Perception ◽  
Sleep Regulation ◽  
Circadian Rhythm Sleep Disorder

Daily expression of clock genes in whole blood cells in healthy subjects and a patient with circadian rhythm sleep disorder

2005 ◽  
Vol 289 (5) ◽  
pp. R1273-R1279 ◽  
Author(s):  
Mieko Takimoto ◽  
Akinobu Hamada ◽  
Akemi Tomoda ◽  
Shigehiro Ohdo ◽  
Takafumi Ohmura ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Sleep Disorder ◽  
Clinical Features ◽  
Whole Blood ◽  
Blood Cells ◽  
Clock Genes ◽  
Circadian Rhythm Sleep Disorders ◽  
Circadian Rhythm Sleep Disorder ◽  
Whole Blood Cells ◽  
Peak Phase

In recent years, circadian rhythm sleep disorders in humans have been increasing. Clinical features characteristic of this disorder are well known, but the specific causes remain unknown. However, various derangements of circadian expression of the clock gene are a probable cause of this disease. We have attempted to elucidate the relationship between the expression of the clock genes in whole blood cells and the clinical features characteristic of this disorder. In this study, we indicate the daily expression of clock genes period ( Per) 1, 2, 3, Bmal1, and Clock in whole blood cells in 12 healthy male subjects. The peak phase of Per1, Per2, and Per3 appeared in the early morning, whereas that of Bmal1 and Clock appeared in the midnight hours. Furthermore, in one patient case with circadian rhythm sleep disorder, we observed variations of the peak phase in clock genes by treatments such as light therapy, exercise therapy, and medicinal therapy. This study suggested that the monitoring of human clock genes in whole blood cells, which may be functionally important for the molecular control of the circadian pacemaker as well as in suprachiasmatic nucleus, might be useful to evaluate internal synchronization.

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