PPARα Mediated FABP1 Contributes to IgA Nephropathy via Regulating Ferroptosis in Human Mesangial Cells

2021 ◽  
Author(s):  
Jingkui Wu ◽  
Xinghua Shao ◽  
Jianxiao Shen ◽  
Qisheng Lin ◽  
Xuying Zhu ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Mesangial Cells ◽  
Human Mesangial Cells

scholarly journals IgA1 immune complexes from pediatric patients with IgA nephropathy activate cultured human mesangial cells

2011 ◽  
Vol 26 (11) ◽  
pp. 3451-3457 ◽  
Author(s):  
Jan Novak ◽  
Leona Raskova Kafkova ◽  
Hitoshi Suzuki ◽  
Milan Tomana ◽  
Karel Matousovic ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Immune Complexes ◽  
Pediatric Patients ◽  
Mesangial Cells ◽  
Human Mesangial Cells

scholarly journals Increased binding of polymeric λ-IgA to cultured human mesangial cells in IgA nephropathy

1996 ◽  
Vol 49 (3) ◽  
pp. 839-845 ◽  
Author(s):  
Kar Neng Lai ◽  
Wah Yuen To ◽  
Philip K.T. Li ◽  
Joseph C.K. Leung
Keyword(s):  
Iga Nephropathy ◽  
Mesangial Cells ◽  
Human Mesangial Cells

scholarly journals Circulating serum lectins of patients with IgA nephropathy stimulate IL-6 release from mesangial cells.

1997 ◽  
Vol 8 (2) ◽  
pp. 208-213
Author(s):  
C Libetta ◽  
T Rampino ◽  
G Palumbo ◽  
C Esposito ◽  
A Dal Canton
Keyword(s):  
Affinity Chromatography ◽  
Iga Nephropathy ◽  
Mesangial Cells ◽  
Lectin Binding ◽  
Normal Serum ◽  
In Vitro Studies ◽  
Human Mesangial Cells ◽  
Serum Activity ◽  
Peripheral Leukocytes

Previously, the authors reported that the serum of patients with immunoglobulin (Ig) A nephropathy stimulated peripheral leukocytes, and this effect was inhibited by nominal haptens for lectins. In vitro studies have shown that lectins can bind to rat mesangial cells and cause their activation. This study was performed to investigate whether the serum of IgA nephropathy patients contains lectins that activate mesangial cells, i.e., induce release of interleukin (IL)-6, a nephritogenic cytokine. The serum of patients was adsorbed by affinity chromatography on resins loaded with lectin-binding sugars. After adsorption, serum supernatant was collected and the resins were then eluted. Human mesangial cells were conditioned with native serum, post-adsorption supernatant, and eluate (all three at 10%) for 24 h, and the release of IL-6 was determined by ELISA. Normal serum was used as control. Incubation of mesangial cells with IgA nephropathy patients serum raised average IL-6 release from 8.5 pg/mL to 274.1 pg/mL. Adsorption in beta-D-glucose and N-acetyl-D-glucosamine caused a fall in the activity of patients' serum, to 17.0 and 63.7 pg/mL, respectively, and the activity lost was recovered in the eluate (185.2 and 142.7 pg/mL, respectively). Neither adsorption on N-acetyl-D-galactosamine nor on fucosylamine was associated with any effect on serum activity; accordingly, no activity was found in the eluates. Serum of patients with non-IgA mesangiocapillary nephritis did not stimulate mesangial cells. These results show that the serum of IgA nephropathy patients contains specific lectins that stimulate IL-6 nephropathy by mesangial cells and are, therefore, potential nephritogenic.

scholarly journals The Combined Role of Galactose-Deficient IgA1 and Streptococcal IgA–Binding M Protein in Inducing IL-6 and C3 Secretion from Human Mesangial Cells: Implications for IgA Nephropathy

2014 ◽  
Vol 193 (1) ◽  
pp. 317-326 ◽  
Author(s):  
Roland Schmitt ◽  
Anne-lie Ståhl ◽  
Anders I. Olin ◽  
Ann-Charlotte Kristoffersson ◽  
Johan Rebetz ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Mesangial Cells ◽  
M Protein ◽  
Human Mesangial Cells
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