Effects of Gestational Exposure to Bisphenol a on the Hepatic Transcriptome and Lipidome of Rat Dams: Intergenerational Comparison of Effects in the Offspring

2021 ◽  
Author(s):  
Hoa Thanh Nguyen ◽  
Lingyun Li ◽  
Akifumi Eguchi ◽  
Tetsuro Agusa ◽  
Kimika Yamamoto ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Gestational Exposure ◽  
Hepatic Transcriptome ◽  
Intergenerational Comparison

Effects of gestational exposure to bisphenol-A on the development of diabetes in mothers

2016 ◽  
Vol 259 ◽  
pp. S31-S32
Author(s):  
P. Alonso-Magdalena ◽  
M. García-Arévalo ◽  
I. Quesada ◽  
Á. Nadal
Keyword(s):  
Bisphenol A ◽  
Gestational Exposure

scholarly journals Gestational Exposure to Low Dose Bisphenol A Alters Social Behavior in Juvenile Mice

PLoS ONE ◽  
2011 ◽  
Vol 6 (9) ◽  
pp. e25448 ◽  
Author(s):  
Jennifer T. Wolstenholme ◽  
Julia A. Taylor ◽  
Savera R. J. Shetty ◽  
Michelle Edwards ◽  
Jessica J. Connelly ◽  
...  
Keyword(s):  
Social Behavior ◽  
Bisphenol A ◽  
Low Dose ◽  
Gestational Exposure

scholarly journals Gestational Exposure to Bisphenol A Affects the Function and Proteome Profile of F1 Spermatozoa in Adult Mice

2017 ◽  
Vol 125 (2) ◽  
pp. 238-245 ◽  
Author(s):  
Md Saidur Rahman ◽  
Woo-Sung Kwon ◽  
Polash Chandra Karmakar ◽  
Sung-Jae Yoon ◽  
Buom-Yong Ryu ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Adult Mice ◽  
Gestational Exposure ◽  
Proteome Profile

Functional and Proteomic Alterations of F1 Capacitated Spermatozoa of Adult Mice Following Gestational Exposure to Bisphenol A

2017 ◽  
Vol 17 (1) ◽  
pp. 524-535 ◽  
Author(s):  
Md Saidur Rahman ◽  
Woo-Sung Kwon ◽  
Do-Yeal Ryu ◽  
Amena Khatun ◽  
Polash Chandra Karmakar ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Adult Mice ◽  
Gestational Exposure

scholarly journals Gestational Exposure to Bisphenol A and Bisphenol S Leads to Fetal Skeletal Muscle Hypertrophy Independent of Sex

2019 ◽  
Vol 172 (2) ◽  
pp. 292-302
Author(s):  
Jiongjie Jing ◽  
Yong Pu ◽  
Jeremy Gingrich ◽  
Almudena Veiga-Lopez
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Bisphenol A ◽  
Muscle Development ◽  
Fiber Type ◽  
Bisphenol S ◽  
Gestational Exposure ◽  
Gene And Protein Expression ◽  
Pregnant Sheep ◽  
Fiber Size

Abstract Gestational exposure to bisphenol A (BPA) can lead to offspring insulin resistance. However, despite the role that the skeletal muscle plays in glucose homeostasis, it remains unknown whether gestational exposure to BPA, or its analog bisphenol S (BPS), impairs skeletal muscle development. We hypothesized that gestational exposure to BPA or BPS will impair fetal muscle development and lead to muscle-specific insulin resistance. To test this, pregnant sheep (n = 7–8/group) were exposed to BPA or BPS from gestational day (GD) 30 to 100. At GD120, fetal skeletal muscle was harvested to evaluate fiber size, fiber type, and gene and protein expression related to myogenesis, fiber size, fiber type, and inflammation. Fetal primary myoblasts were isolated to evaluate proliferation and differentiation. In fetal skeletal muscle, myofibers were larger in BPA and BPS groups in both females and males. BPA females had higher MYH1 (reflective of type-IIX fast glycolytic fibers), whereas BPS females had higher MYH2 and MYH7, and higher myogenic regulatory factors (Myf5, MyoG, MyoD, and MRF4) mRNA expression. No differences were observed in males. Myoblast proliferation was not altered in gestationally BPA- or BPS-exposed myoblasts, but upon differentiation, area and diameter of myotubes were larger independent of sex. Females had larger myofibers and myotubes than males in all treatment groups. In conclusion, gestational exposure to BPA or BPS does not result in insulin resistance in fetal myoblasts but leads to fetal fiber hypertrophy in skeletal muscle independent of sex and alters fiber type distribution in a sex-specific manner.

Gestational exposure to bisphenol-A increases susceptibility of adult mice to development of EAE

2014 ◽  
Vol 275 (1-2) ◽  
pp. 170
Author(s):  
James Rogers ◽  
Claudia Silva ◽  
Luanne Metz ◽  
Olga Kovalchuk ◽  
V. Wee Yong
Keyword(s):  
Bisphenol A ◽  
Adult Mice ◽  
Gestational Exposure

Effects of prenatal bisphenol A exposure on the hepatic transcriptome and proteome in rat offspring

2020 ◽  
Vol 720 ◽  
pp. 137568 ◽  
Author(s):  
Hoa Thanh Nguyen ◽  
Kimika Yamamoto ◽  
Midori Iida ◽  
Tetsuro Agusa ◽  
Mari Ochiai ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Rat Offspring ◽  
Hepatic Transcriptome
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