GelMA-Alginate Core-Shell Microcapsules as Efficient Delivery Platform For Prevascularized Microtissues in Endodontic Regeneration

2021 ◽  
Author(s):  
Xi Liang ◽  
Li Xie ◽  
Qingyuan Zhang ◽  
Ge Wang ◽  
Siyuan Zhang ◽  
...  
Keyword(s):  
Core Shell ◽  
Efficient Delivery ◽  
Delivery Platform ◽  
Endodontic Regeneration

scholarly journals Neurotransmitter-derived lipidoids (NT-lipidoids) for enhanced brain delivery through intravenous injection

2020 ◽  
Vol 6 (30) ◽  
pp. eabb4429
Author(s):  
Feihe Ma ◽  
Liu Yang ◽  
Zhuorui Sun ◽  
Jinjin Chen ◽  
Xuehui Rui ◽  
...  
Keyword(s):  
Intravenous Injection ◽  
Brain Function ◽  
Antisense Oligonucleotides ◽  
Brain Delivery ◽  
Central Nervous System Diseases ◽  
Efficient Delivery ◽  
Delivery Platform ◽  
Or Gene ◽  
The Brain ◽  
Lipid Formulations

Safe and efficient delivery of blood-brain barrier (BBB)–impermeable cargos into the brain through intravenous injection remains a challenge. Here, we developed a previously unknown class of neurotransmitter–derived lipidoids (NT-lipidoids) as simple and effective carriers for enhanced brain delivery of several BBB-impermeable cargos. Doping the NT-lipidoids into BBB-impermeable lipid nanoparticles (LNPs) gave the LNPs the ability to cross the BBB. Using this brain delivery platform, we successfully delivered amphotericin B (AmB), antisense oligonucleotides (ASOs) against tau, and genome-editing fusion protein (−27)GFP-Cre recombinase into the mouse brain via systemic intravenous administration. We demonstrated that the NT-lipidoid formulation not only facilitates cargo crossing of the BBB, but also delivery of the cargo into neuronal cells for functional gene silencing or gene recombination. This class of brain delivery lipid formulations holds great potential in the treatment of central nervous system diseases or as a tool to study the brain function.

scholarly journals Preparation of polyacrylamide/polylactic acid co-assembled core/shell nanofibers as designed beads for dapsone in vitro efficient delivery

2019 ◽  
Vol 47 (1) ◽  
pp. 917-926
Author(s):  
Mehdi Ranjbar ◽  
Payam Khazaeli ◽  
Abbas Pardakhty ◽  
Batool Tahamipour ◽  
Arezou Amanatfard
Keyword(s):  
Polylactic Acid ◽  
Core Shell ◽  
Efficient Delivery

scholarly journals The Multifunctionally Graded System for a Controlled Size Effect on Iron Oxide–Gold Based Core-Shell Nanoparticles

Nanomaterials ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1695
Author(s):  
Bo-Wei Du ◽  
Chih-Yuan Chu ◽  
Ching-Chang Lin ◽  
Fu-Hsiang Ko
Keyword(s):  
Magnetic Field ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Au Nps ◽  
Size Dependent ◽  
Short Period ◽  
Frequency Magnetic Field ◽  
Delivery Platform ◽  
Core Shell Nanoparticles ◽  
Shielding Effects

We report that Fe3O4@Au core-shell nanoparticles (NPs) serve as a multifunctional molecule delivery platform. This platform is also suitable for sensing the doxorubicin (DOX) through DNA hybridization, and the amount of carried DOX molecules was determined by size-dependent Fe3O4@Au NPs. The limits of detection (LODs) for DOX was found to be 1.839 nM. In our approach, an Au nano-shell coating was coupled with a specially designed DNA sequence using thiol bonding. By means of a high-frequency magnetic field (HFMF), a high release percentage of such a molecule could be efficiently achieved in a relatively short period of time. Furthermore, the thickness increase of the Au nano-shell affords Fe3O4@Au NPs with a larger surface area and a smaller temperature increment due to shielding effects from magnetic field. The change of magnetic property may enable the developed Fe3O4@Au-dsDNA/DOX NPs to be used as future nanocarrier material. More importantly, the core-shell NP structures were demonstrated to act as a controllable and efficient factor for molecule delivery.

Phenylboronic Acid-based Core-Shell Drug Delivery Platform Clasping 1,3-Dicarbonyl Compounds by A Coordinate Interaction

2021 ◽  
Author(s):  
Sungjin Jung ◽  
Junseok Lee ◽  
Won Jong Kim
Keyword(s):  
Drug Delivery ◽  
Natural Compound ◽  
Phenylboronic Acid ◽  
Natural Compounds ◽  
Clinical Applications ◽  
Core Shell ◽  
Dicarbonyl Compounds ◽  
Delivery Platform

Along with the successful commercialization of chemotherapeutics, such as doxorubicin and paclitaxel, numerous natural compounds have been investigated for clinical applications. Recently, curcumin (CUR), a natural compound with various therapeutic...

Core–shell-type lipid–polymer hybrid nanoparticles as a drug delivery platform

2013 ◽  
Vol 9 (4) ◽  
pp. 474-491 ◽  
Author(s):  
Bivash Mandal ◽  
Himanshu Bhattacharjee ◽  
Nivesh Mittal ◽  
Hongkee Sah ◽  
Pavan Balabathula ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hybrid Nanoparticles ◽  
Core Shell ◽  
Polymer Hybrid ◽  
Shell Type ◽  
Delivery Platform

Efficient delivery of quercetin after binding to beta-lactoglobulin followed by formation soft-condensed core-shell nanostructures

2017 ◽  
Vol 233 ◽  
pp. 282-289 ◽  
Author(s):  
Seyedeh Fatemeh Mirpoor ◽  
Seyed Mohammad Hashem Hosseini ◽  
Abdo-Reza Nekoei
Keyword(s):  
Core Shell ◽  
Shell Nanostructures ◽  
Efficient Delivery ◽  
Beta Lactoglobulin

Core–shell nanoparticles as a drug delivery platform for tumor targeting

2018 ◽  
pp. 387-448 ◽  
Author(s):  
Namdev L. Dhas ◽  
Nisith J. Raval ◽  
Ritu R. Kudarha ◽  
Niyati S. Acharya ◽  
Sanjeev R. Acharya
Keyword(s):  
Drug Delivery ◽  
Tumor Targeting ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Delivery Platform ◽  
Core Shell Nanoparticles
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