The Potential Benefits of Molsidomine, a Nitric Oxide Donor, on Hyperoxic Lung Injury in Neonatal Rats

2021 ◽  
Author(s):  
Ramazan Ozdemir ◽  
Ismail Kursat Gokce ◽  
Hatice Turgut ◽  
Suat Tekin ◽  
Asli Cetin Taslidere ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Lung Injury ◽  
Nitric Oxide Donor ◽  
Neonatal Rats ◽  
Hyperoxic Lung Injury ◽  
Potential Benefits

Dexpanthenol therapy reduces lung damage in a hyperoxic lung injury in neonatal rats

2015 ◽  
pp. 1-7 ◽  
Author(s):  
Ramazan Ozdemir ◽  
Gulsum Demirtas ◽  
Hakan Parlakpinar ◽  
Alaadin Polat ◽  
Kevser Tanbag ◽  
...  
Keyword(s):  
Lung Injury ◽  
Lung Damage ◽  
Neonatal Rats ◽  
Hyperoxic Lung Injury

scholarly journals Ferroptosis is Involved in Hyperoxic Lung Injury in Neonatal Rats

2021 ◽  
Vol Volume 14 ◽  
pp. 5393-5401
Author(s):  
Danyun Jia ◽  
Jinyu Zheng ◽  
Yiyang Zhou ◽  
Jinqiu Jia ◽  
Xiaoxiao Ye ◽  
...  
Keyword(s):  
Lung Injury ◽  
Neonatal Rats ◽  
Hyperoxic Lung Injury

Aerosolized Soluble Nitric Oxide Donor Improves Oxygenation and Pulmonary Hypertension in Acute Lung Injury

1998 ◽  
Vol 158 (5) ◽  
pp. 1536-1542 ◽  
Author(s):  
BRIAN R. JACOBS ◽  
RICHARD J. BRILLI ◽  
EDGAR T. BALLARD ◽  
DANIEL J. PASSERINI ◽  
DANIEL J. SMITH
Keyword(s):  
Nitric Oxide ◽  
Pulmonary Hypertension ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Nitric Oxide Donor

Beneficial Effects of Supplemental Nitric Oxide Donor Given during Reperfusion Period in Reperfusion-Induced Lung Injury

2006 ◽  
Vol 54 (7) ◽  
pp. 477-483 ◽  
Author(s):  
H. Esme ◽  
H. Fidan ◽  
O. Solak ◽  
F. Dilek ◽  
R. Demirel ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Lung Injury ◽  
Nitric Oxide Donor ◽  
Beneficial Effects ◽  
Reperfusion Period

scholarly journals Inhaled Nitric Oxide Attenuates Hyperoxic Lung Injury in Lambs

2006 ◽  
Vol 59 (1) ◽  
pp. 142-146 ◽  
Author(s):  
Robert B Cotton ◽  
Håkan W Sundell ◽  
Darryl C Zeldin ◽  
Jason D Morrow ◽  
L Jackson Roberts ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Lung Injury ◽  
Inhaled Nitric Oxide ◽  
Hyperoxic Lung Injury

Azithromycin Protects Against Hyperoxic Lung Injury in Neonatal Rats

2007 ◽  
Vol 55 (6) ◽  
pp. 299-305 ◽  
Author(s):  
Hubert O. Ballard ◽  
Philip Bernard ◽  
Joseph Qualls ◽  
William Everson ◽  
Lori A. Shook
Keyword(s):  
Lung Injury ◽  
Neonatal Rats ◽  
Hyperoxic Lung Injury

scholarly journals A novel potent inhibitor of inducible nitric oxide synthase, ONO-1714, reduces hyperoxic lung injury in mice

2007 ◽  
Vol 101 (4) ◽  
pp. 793-799 ◽  
Author(s):  
Tatsuya Yuba ◽  
Kazuhiro Nagata ◽  
Tadaaki Yamada ◽  
Shuji Osugi ◽  
Hiroomi Kuwahara ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Lung Injury ◽  
Inducible Nitric Oxide Synthase ◽  
Potent Inhibitor ◽  
Hyperoxic Lung Injury ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Beneficial Effect of Etanercept on Hyperoxic Lung Injury Model in Neonatal Rats

2015 ◽  
Vol 29 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Mehmet Yekta Oncel ◽  
Sadik Yurttutan ◽  
Evrim Alyamac Dizdar ◽  
Ismail Kursat Gokce ◽  
Ipek Isik Gonul ◽  
...  
Keyword(s):  
Lung Injury ◽  
Beneficial Effect ◽  
Neonatal Rats ◽  
Injury Model ◽  
Lung Injury Model ◽  
Hyperoxic Lung Injury

scholarly journals Effects of Nitric Oxide Donor on the Lung Functions in a Saline Lavage-Induced Model of ARDS

2019 ◽  
pp. S265-S273 ◽  
Author(s):  
P. KOSUTOVA ◽  
P. MIKOLKA ◽  
S. BALENTOVA ◽  
M. ADAMKOV ◽  
D. MOKRA
Keyword(s):  
Nitric Oxide ◽  
Lung Injury ◽  
Cell Count ◽  
Nitric Oxide Donor ◽  
Control Group ◽  
Lung Edema ◽  
Edema Formation ◽  
Respiratory Parameters ◽  
Lung Functions ◽  
Saline Lavage

Acute respiratory distress syndrome (ARDS) is characterized by acute hypoxemia, neutrophil-mediated inflammation, and lung edema formation. Whereas lung damage might be alleviated by nitric oxide (NO), goal of this study was to evaluate if intratracheal NO donor S-nitroso-N-acetylpenicillamine (SNAP) can positively influence the lung functions in experimental model of ARDS. New Zealand rabbits with respiratory failure induced by saline lavage (30 ml/kg, 9±3 times) were divided into: ARDS group without therapy, ARDS group treated with SNAP (7 mg/kg i.t.), and healthy Control group. During 5 h of ventilation, respiratory parameters (blood gases, ventilatory pressures) were estimated. After anesthetics overdosing, left lung was saline-lavaged and cell count, cell viability and protein content in bronchoalveolar lavage fluid (BALF) were measured. Right lung tissue was used for estimation of wet/dry weight ratio, concentration of NO metabolites, and histomorphological investigation. Repetitive lung lavage induced lung injury, worsened gas exchange, and damaged alveolar-capillary membrane. Administration of SNAP reduced cell count in BALF, lung edema formation, NO metabolites, and histopathological signs of injury, and improved respiratory parameters. Treatment with intratracheal SNAP alleviated lung injury and edema and improved lung functions in a saline-lavaged model of ARDS suggesting a potential of NO donors also for patients with ARDS.

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