Risk Factors and Specific Cancer Types of Second Primary Malignancies in Patients With Breast Cancer Receiving Adjuvant Radiotherapy: A Case–Control Cohort Study Based on the SEER Database

2021 ◽  
Author(s):  
Chuanxin Xia ◽  
Lei Qin ◽  
Yinzhi Wang ◽  
Ling Yao ◽  
Ben-Chang Shia ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Adjuvant Radiotherapy ◽  
Case Control ◽  
Second Primary ◽  
Seer Database ◽  
Control Cohort ◽  
Specific Cancer ◽  
Cancer Types ◽  
Second Primary Malignancies ◽  
Control Cohort Study

scholarly journals Effect of breast cancer as the first or second primary cancer on the prognosis of women with thyroid cancer: a SEER database analysis

2020 ◽  
Vol 9 (11) ◽  
pp. 6955-6962
Author(s):  
Jianglong Huang ◽  
Yihui Huang ◽  
Ling Zhou ◽  
Sichao Chen ◽  
Danyang Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Thyroid Cancer ◽  
Second Primary ◽  
Primary Cancer ◽  
Seer Database ◽  
Second Primary Cancer ◽  
Database Analysis

Second primary malignancies in gastric cancer: A U.S. population-based study.

2015 ◽  
Vol 33 (3_suppl) ◽  
pp. 191-191
Author(s):  
Binay Kumar Shah ◽  
Amit Khanal
Keyword(s):  
Breast Cancer ◽  
Prostate Cancer ◽  
Gastric Cancer ◽  
Thyroid Cancer ◽  
Myeloid Leukemia ◽  
Population Based ◽  
Second Primary ◽  
Population Based Study ◽  
Gastrointestinal Malignancies ◽  
Second Primary Malignancies

191 Background: Risk of second primary malignancies (SPM) is not known in gastric cancer. In this population based study, we analyzed rates of SPM in gastric cancer. Methods: We selected adult (≥18 years) patients with gastric cancer as first primary malignancy diagnosed from January 1992 to December 2011 from Surveillance, Epidemiology and End Result 13 database. We used SEER*stat’s multiple primary standardized incidence ratio (MP-SIR) session to calculate the risk of SPM diagnosed 6 months after the diagnosis of index gastric cancer. Results: Among 31,818 patients with first primary gastric cancer, 1674 (5.26%) developed 1,839 SPM with observed/expected (O/E) ratio of 1.09 (95% CI = 1.05-1.15, p<0.0001) and excess risk of 16.15 per 10,000 population. The median time to first SPM from the time of diagnosis of stomach cancer was 49 months (range 6 months to 19.08 years). There was significantly increased risk of gastrointestinal malignancies [O/E ratio 1.65 (CI=1.53-1.79, p<0.001)], thyroid cancer [O/E ratio 1.98 (CI=1.32-2.84, p<0.01)] and myeloid leukemia [O/E ratio 1.47(CI=1-2.09, p<0.05)]. Interestingly, there was significantly decreased risk of melanoma, breast cancer and prostate cancer. Conclusions: Our study showed that patients with gastric cancer are at higher risk of gastrointestinal malignancies, thyroid cancer and myeloid leukemia. Similarly, risk of melanoma, breast cancer and prostate cancer in patients with gastric cancer is lower than general population.

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