Antioxidant Therapy Reverses Sympathetic Dysfunction, Oxidative Stress and Hypertension in Male Hyperadipose Rats

2021 ◽  
Author(s):  
Fernanda Cortegoso Lopes ◽  
Natália Veronez da Cunha ◽  
Blenda de Campos ◽  
Victor Fattori ◽  
Carolina Panis ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Therapy ◽  
Sympathetic Dysfunction

scholarly journals Effect of Antioxidant Therapy on Oxidative Stress In Vivo

Antioxidants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 344
Author(s):  
Anna Maria Fratta Pasini ◽  
Luciano Cominacini
Keyword(s):  
Oxidative Stress ◽  
Cardiovascular Diseases ◽  
Neurodegenerative Diseases ◽  
Antioxidant Therapy ◽  
Potential Benefits

Over the last few decades, many efforts have been put into fields that explore the potential benefits of antioxidants, especially with regards to aging, cancer, cardiovascular diseases, and neurodegenerative diseases. [...]

Defective Ag-In-S/ZnS Quantum Dots: An Oxygen-derived Free Radicals Scavenger for Mitigating the Macrophage Inflammation

2021 ◽  
Author(s):  
Na Gao ◽  
Jing Jing ◽  
Hengzhi Zhao ◽  
Yazhou Liu ◽  
Chunlei Yang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Quantum Dots ◽  
Heart Disease ◽  
Free Radicals ◽  
Inflammatory Diseases ◽  
Antioxidant Therapy ◽  
Oxygen Derived Free Radicals ◽  
Promising Strategy

Oxidative stress plays an important role in the development of inflammatory diseases including allergy, heart disease, diabetes and cancer. Nanomaterials-mediated antioxidant therapy is regarded as a promising strategy to treat...

scholarly journals Oxidative Stress and Antioxidant Therapy in Critically Ill Polytrauma Patients with Severe Head Injury

2015 ◽  
Vol 1 (3) ◽  
pp. 83-91 ◽  
Author(s):  
Loredana Luca ◽  
Alexandru Florin Rogobete ◽  
Ovidiu Horea Bedreag
Keyword(s):  
Oxidative Stress ◽  
Critically Ill ◽  
Clinical Status ◽  
Antioxidant Therapy ◽  
Pathophysiological Mechanism ◽  
Microvascular Damage ◽  
Traumatic Injuries ◽  
Blood Brain Barrier Disruption ◽  
Brain Barrier Disruption ◽  
Blood Spinal Cord Barrier

Abstract Traumatic Brain Injury (TBI) is one of the leading causes of death among critically ill patients from the Intensive Care Units (ICU). After primary traumatic injuries, secondary complications occur, which are responsible for the progressive degradation of the clinical status in this type of patients. These include severe inflammation, biochemical and physiological imbalances and disruption of the cellular functionality. The redox cellular potential is determined by the oxidant/antioxidant ratio. Redox potential is disturbed in case of TBI leading to oxidative stress (OS). A series of agression factors that accumulate after primary traumatic injuries lead to secondary lesions represented by brain ischemia and hypoxia, inflammatory and metabolic factors, coagulopathy, microvascular damage, neurotransmitter accumulation, blood-brain barrier disruption, excitotoxic damage, blood-spinal cord barrier damage, and mitochondrial dysfunctions. A cascade of pathophysiological events lead to accelerated production of free radicals (FR) that further sustain the OS. To minimize the OS and restore normal oxidant/antioxidant ratio, a series of antioxidant substances is recommended to be administrated (vitamin C, vitamin E, resveratrol, N-acetylcysteine). In this paper we present the biochemical and pathophysiological mechanism of action of FR in patients with TBI and the antioxidant therapy available.

Role of oxidative stress and antioxidant therapy in acute and chronic phases of sulfur mustard injuries: a review

2018 ◽  
Vol 38 (1) ◽  
pp. 9-17 ◽  
Author(s):  
Asghar Beigi Harchegani ◽  
Abolfazl Khor ◽  
Eisa Tahmasbpour ◽  
Mahdi Ghatrehsamani ◽  
Hamid Bakhtiari Kaboutaraki ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Sulfur Mustard ◽  
Antioxidant Therapy

scholarly journals Corrigendum to “Oxidative stress and antioxidant therapy in cystic fibrosis” [Biochim. Biophys. Acta 1822 (2012) 690–713]

2014 ◽  
Vol 1842 (12) ◽  
pp. 2531
Author(s):  
Francesco Galli ◽  
Andrea Battistoni ◽  
Roberto Gambari ◽  
Alfonso Pompella ◽  
Alessandra Bragonzi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cystic Fibrosis ◽  
Antioxidant Therapy

scholarly journals REducing Deaths due to OXidative Stress (The REDOXS© Study): rationale and study design for a randomized trial of glutamine and antioxidant supplementation in critically-ill patients

2006 ◽  
Vol 65 (3) ◽  
pp. 250-263 ◽  
Author(s):  
Daren K. Heyland ◽  
Rupinder Dhaliwal ◽  
Andrew G. Day ◽  
John Muscedere ◽  
John Drover ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Randomized Trial ◽  
Critically Ill ◽  
Organ Dysfunction ◽  
Critically Ill Patients ◽  
Tertiary Care ◽  
Antioxidant Therapy ◽  
Favourable Effect ◽  
High Dose ◽  
Antioxidant Supplementation

Critically-ill patients experience an extent of hyperinflammation, cellular immune dysfunction, oxidative stress and mitochondrial dysfunction. Supplementation with key nutrients, such as glutamine and antioxidants, is most likely to have a favourable effect on these physiological derangements, leading to an improvement in clinical outcomes. The results of two meta-analyses suggest that glutamine and antioxidants may be associated with improved survival. The purpose of the present paper is to report the background rationale and study protocol for the evaluation of the effect of high-dose glutamine and antioxidant supplementation on mortality in a large-scale randomized trial in 1200 mechanically-ventilated, critically-ill patients. Patients admitted to an intensive care unit (ICU) with clinical evidence of severe organ dysfunction will be randomized to one of four treatments in a 2×2 factorial design: (1) glutamine; (2) antioxidant therapy; (3) glutamine and antioxidant therapy; (4) placebo. The primary outcome for this study is 28 d mortality. The secondary outcomes are duration of stay in ICU, adjudicated diagnosis of infection, multiple organ dysfunction, duration of mechanical ventilation, length of stay in hospital and health-related quality of life at 3 and 6 months. A novel design feature is the combined use of parenteral and enteral study nutrients dissociated from the nutrition support. The therapeutic strategies tested in the randomized trial may lead to less morbidity and improved survival in critically-ill patients. The trial will be conducted in approximately twenty tertiary-care ICU in Canada and the first results are expected in 2009.

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