Developing an Ultrasensitive Glutathione Fluorescence Probe Using a Screen Strategy: Tracking Stroke-Induced Ferroptosis Via In Vivo and In Vitro Imaging

2021 ◽  
Author(s):  
Xiaoxing Xiong ◽  
Yingze Ye ◽  
Xiaoyang Gao ◽  
Hua Zhu ◽  
Wei Hu ◽  
...  
Keyword(s):  
Fluorescence Probe ◽  
Screen Strategy

scholarly journals Fluorescence Tumor-Imaging Using a Thermo-Responsive Molecule with an Emissive Aminoquinoline Derivative

Nanomaterials ◽  
2018 ◽  
Vol 8 (10) ◽  
pp. 782 ◽  
Author(s):  
Takeru Araki ◽  
Yasufumi Fuchi ◽  
Shuhei Murayama ◽  
Ryoma Shiraishi ◽  
Tokimi Oyama ◽  
...  
Keyword(s):  
Cloud Point ◽  
Intravenous Administration ◽  
Tumor Tissue ◽  
Tumor Imaging ◽  
Fluorescence Probe ◽  
Local Heat ◽  
Solution Temperature ◽  
Lcst Behavior

We synthesized (2,4-trifluoromethyl-7-N-bis(2,5,8,11-tetraoxatridecane-13-yl)-aminoquinoline) TFMAQ-diEg4, an emissive aminoquinoline derivative that incorporated two tetraethyleneglycol chains into an amino group. TFMAQ-diEg4 showed fluorescence and thermo-responsive properties accompanied by a lower critical solution temperature (LCST), due to the introduction of the oligoethylene glycol chain. This thermo-responsive LCST behavior occurred at the border of a cloud point. Below and above the cloud point, self-assemblies of 6-7-nm nanoparticles and ~2000-nm microparticles were observed, in vitro. In addition, TFMAQ-diEg4 showed a high solubility, over 20 mM for aqueous solution, in vivo, which not only prevented thrombosis but also allowed various examinations, such as single intravenous administration and intravenous drips. Intravenous administration of TFMAQ-diEg4, to tumor-bearing, mice led to the accumulation of the molecule in the tumor tissue, as observed by fluorescence imaging. A subset of mice was treated with local heat around their tumor tissue and an intravenous drip of TFMAQ-diEg4, which led to a high intensity of TFMAQ-diEg4 emission within the tumor tissue. Therefore, we revealed that TFMAQ-diEg4 was useful as a fluorescence probe with thermo-responsive properties.

scholarly journals A fast response fluorescence probe specific for hypochlorous acid detection and its applications in bioimaging

2018 ◽  
Vol 16 (12) ◽  
pp. 2074-2082 ◽  
Author(s):  
Hongmin Jia ◽  
Shuhe Xia ◽  
Huan Feng ◽  
Qingtao Meng ◽  
Chengchen Duan ◽  
...  
Keyword(s):  
Hypochlorous Acid ◽  
Fluorescence Probe ◽  
High Sensitivity ◽  
Fast Response ◽  
Rapid Response

The features ofDNPH-NA, including its high sensitivity, selectivity, and reliability at physiological pH, together with a rapid response, enable its successful application in the detection of endogenous HOClin vitroandin vivo.

Naked-Eye and Near-Infrared Fluorescence Probe for Hydrazine and Its Applications in In Vitro and In Vivo Bioimaging

2015 ◽  
Vol 87 (17) ◽  
pp. 9101-9107 ◽  
Author(s):  
Jianjian Zhang ◽  
Lulu Ning ◽  
Jiting Liu ◽  
Jianxi Wang ◽  
Bianfei Yu ◽  
...  
Keyword(s):  
Near Infrared ◽  
Fluorescence Probe ◽  
Near Infrared Fluorescence ◽  
Naked Eye

A near-infrared xanthene fluorescence probe for monitoring peroxynitrite in living cells and mouse inflammation model

The Analyst ◽  
2018 ◽  
Vol 143 (22) ◽  
pp. 5512-5519 ◽  
Author(s):  
Yongquan Wu ◽  
Aiping Shi ◽  
Yuanyan Li ◽  
Hong Zeng ◽  
Xiaoyong Chen ◽  
...  
Keyword(s):  
Near Infrared ◽  
Fluorescence Probe ◽  
Living Cells ◽  
Inflammation Model

A novel near-infrared xanthene fluorescence probe for monitoring peroxynitrite in vitro and in vivo.

A mitochondrial targeting two-channel responsive fluorescence probe for imaging the superoxide radical anion in vitro and in vivo

Talanta ◽  
2019 ◽  
Vol 194 ◽  
pp. 79-85 ◽  
Author(s):  
Ning Zhang ◽  
Yun He ◽  
Qing Tang ◽  
Yanfang Wang ◽  
Qiang Zheng ◽  
...  
Keyword(s):  
Radical Anion ◽  
Superoxide Radical ◽  
Fluorescence Probe ◽  
Mitochondrial Targeting ◽  
Superoxide Radical Anion

A novel NIR fluorescence probe with cysteine-activated structure for specific detection of cysteine and its application in vitro and in vivo

Talanta ◽  
2021 ◽  
Vol 223 ◽  
pp. 121758
Author(s):  
Chunpo Ge ◽  
Fengge Shen ◽  
Yanyan Yin ◽  
Kaiwen Chang ◽  
Xuan Zhang ◽  
...  
Keyword(s):  
Fluorescence Probe ◽  
Specific Detection ◽  
Nir Fluorescence

A novel Near-Infrared rhodamine-derivated turn-on fluorescence probe for sensing SO32− detection and their bio-imaging in vitro and in vivo

2021 ◽  
Vol 188 ◽  
pp. 109229
Author(s):  
Kai Wang ◽  
Wei Wang ◽  
Shi-Yu Chen ◽  
Jia-Cheng Guo ◽  
Jia-Heng Li ◽  
...  
Keyword(s):  
Near Infrared ◽  
Fluorescence Probe ◽  
Turn On ◽  
Bio Imaging

A phosphinate-based near-infrared fluorescence probe for imaging the superoxide radical anion in vitro and in vivo

2016 ◽  
Vol 52 (13) ◽  
pp. 2679-2682 ◽  
Author(s):  
Jianjian Zhang ◽  
Chuwen Li ◽  
Rui Zhang ◽  
Fengyuan Zhang ◽  
Wei Liu ◽  
...  
Keyword(s):  
Radical Anion ◽  
Near Infrared ◽  
Superoxide Radical ◽  
Fluorescence Probe ◽  
Limit Of Detection ◽  
Selective Detection ◽  
Superoxide Radical Anion ◽  
Turn On

A novel near-infrared (NIR), turn-on fluorescence probeCyRcontaining a phosphinate group as a recognizing moiety for the selective detection of O2˙−with a low limit of detection (LOD, 9.9 nM) was developed.

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