The Comprehensive Role of Mechanosensitive Piezo1 in Fracture Healing and Delayed Union

2021 ◽  
Author(s):  
Yunlu Liu ◽  
Hongtao Tian ◽  
Yuxiang Hu ◽  
Yulin Cao ◽  
Hui Song ◽  
...  
Keyword(s):  
Fracture Healing ◽  
Delayed Union

Role of Sildenafil in Acceleration of Delayed Union Fracture Healing on Sprague-Dawley Rats Model

2015 ◽  
Vol 8 (5) ◽  
pp. 419-428 ◽  
Author(s):  
Ahmad Fauzi ◽  
Achmad Kamal ◽  
Aryadi Kurniawan ◽  
Evelina Kodrat
Keyword(s):  
Fracture Healing ◽  
Delayed Union ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals Teriparatide in fracture healing: Case series and review of literature

2022 ◽  
Vol 7 (2) ◽  
pp. 93-100
Author(s):  
S S Jha ◽  
Amit B Jain ◽  
Nilanj Dave ◽  
Alok Chaturvedi ◽  
Sandesh Warudkar
Keyword(s):  
Fracture Healing ◽  
Case Reports ◽  
Case Series ◽  
Femoral Fractures ◽  
Delayed Union ◽  
Published Data ◽  
Mechanical Instability ◽  
Mineral Density ◽  
Non Union

Teriparatide (TPTD) (recombinant Parathyroid Hormone 1-34) is one of the pioneer osteo-anabolic agents approved for management of osteoporosis. Being an anabolic agent, it increases bone mineral density by inducing formation of new bone by the action on osteoblasts. As new bone formation is an important aspect of fracture healing as well, Teriparatide has long been a product of interest with respect to its effect on the process of fracture healing. Though fracture healing is not an approved indication for Teriparatide, there is quite a substantial amount of published data related to its effectiveness in fracture healing. With an intent to better understand the role of teriparatide in fracture, we share few case reports of successful fracture healing after giving Teriparatide and also review the published evidences of union taking place in difficult delayed union and non-union cases secondary to mechanical instability, inadequate fixation support or other reasons. This article thus, intended to summarize the accumulating preclinical and clinical evidence for role of TPTD in accelerating fracture healing in various conditions like conservative management of fractures, vertebral fractures, non-unions, delayed unions and atypical femoral fractures.

Role of interleukin-6 in the early and late fracture healing phase

2016 ◽  
Author(s):  
Katja Prystaz ◽  
Anna Kovtun ◽  
Kathrin Kaiser ◽  
Verena Heidler ◽  
Jochen Kroner ◽  
...  
Keyword(s):  
Fracture Healing ◽  
Interleukin 6 ◽  
Healing Phase

scholarly journals The Role of Immune System Cells in Fracture Healing: Review of the Literature and Current Concepts

Cureus ◽  
2021 ◽  
Author(s):  
Dimitrios A Flevas ◽  
Maria G Papageorgiou ◽  
Panagiotis Drakopoulos ◽  
George I Lambrou
Keyword(s):  
Immune System ◽  
Fracture Healing ◽  
Review Of The Literature

scholarly journals Role of Serum Albumin in fracture healing

2015 ◽  
Vol 6 (7) ◽  
pp. 452 ◽  
Author(s):  
Manish Yadav ◽  
Ajai Singh ◽  
Sabir Ali ◽  
Nazia Rizivi ◽  
Syed Rizwan Hussain ◽  
...  
Keyword(s):  
Serum Albumin ◽  
Fracture Healing

scholarly journals What is the role of ultrasound in fracture management?

2019 ◽  
Vol 8 (7) ◽  
pp. 304-312 ◽  
Author(s):  
J. A. Nicholson ◽  
S. T. J. Tsang ◽  
T. J. MacGillivray ◽  
F. Perks ◽  
A. H. R. W. Simpson
Keyword(s):  
Image Processing ◽  
Fracture Healing ◽  
Bone Fractures ◽  
Therapeutic Ultrasound ◽  
Long Bone ◽  
Future Application ◽  
Current Evidence ◽  
Potential Clinical Benefit ◽  
Fracture Management

Objectives The aim of this study was to review the current evidence and future application for the role of diagnostic and therapeutic ultrasound in fracture management. Methods A review of relevant literature was undertaken, including articles indexed in PubMed with keywords “ultrasound” or “sonography” combined with “diagnosis”, “fracture healing”, “impaired fracture healing”, “nonunion”, “microbiology”, and “fracture-related infection”. Results The use of ultrasound in musculoskeletal medicine has expanded rapidly over the last two decades, but the diagnostic use in fracture management is not routinely practised. Early studies have shown the potential of ultrasound as a valid alternative to radiographs to diagnose common paediatric fractures, to detect occult injuries in adults, and for rapid detection of long bone fractures in the resuscitation setting. Ultrasound has also been shown to be advantageous in the early identification of impaired fracture healing; with the advent of 3D image processing, there is potential for wider adoption. Detection of implant-related infection can be improved by ultrasound mediated sonication of microbiology samples. The use of therapeutic ultrasound to promote union in the management of acute fractures is currently a controversial topic. However, there is strong in vitro evidence that ultrasound can stimulate a biological effect with potential clinical benefit in established nonunions, which supports the need for further investigation. Conclusion Modern ultrasound image processing has the potential to replace traditional imaging modalities in several areas of trauma practice, particularly in the early prediction of impaired fracture healing. Further understanding of the therapeutic application of ultrasound is required to understand and identify the use in promoting fracture healing. Cite this article: J. A. Nicholson, S. T. J. Tsang, T. J. MacGillivray, F. Perks, A. H. R. W. Simpson. What is the role of ultrasound in fracture management? Diagnosis and therapeutic potential for fractures, delayed unions, and fracture-related infection. Bone Joint Res 2019;8:304–312. DOI: 10.1302/2046-3758.87.BJR-2018-0215.R2.

The role of MRI in the assessment of scaphoid fracture healing: a pilot study

2000 ◽  
Vol 10 (12) ◽  
pp. 1926-1928 ◽  
Author(s):  
E. G. McNally ◽  
R. Goodman ◽  
P. Burge
Keyword(s):  
Pilot Study ◽  
Fracture Healing ◽  
Scaphoid Fracture

scholarly journals Role of Dynamic Loading on Early Stage of Bone Fracture Healing

2018 ◽  
Vol 46 (11) ◽  
pp. 1768-1784 ◽  
Author(s):  
Smriti Ghimire ◽  
Saeed Miramini ◽  
Martin Richardson ◽  
Priyan Mendis ◽  
Lihai Zhang
Keyword(s):  
Fracture Healing ◽  
Dynamic Loading ◽  
Bone Fracture ◽  
Early Stage ◽  
Bone Fracture Healing
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