Egbuonu, A.C.C., Ezeanyika L.U.S. (2012). Effect of L-arginine on markers of metabolic syndrome related to abdominal obesity and disorder of lipid metabolism in female Wistar albino rats

2012 ◽  
Author(s):  
Anthony Cemaluk C. Egbuonu
Keyword(s):  
Metabolic Syndrome ◽  
Lipid Metabolism ◽  
Abdominal Obesity ◽  
Albino Rats ◽  
Wistar Albino Rats

scholarly journals Lipolytic Postbiotic from Lactobacillus paracasei Manages Metabolic Syndrome in Albino Wistar Rats

Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 472
Author(s):  
Ali Osman ◽  
Nashwa El-Gazzar ◽  
Taghreed N. Almanaa ◽  
Abdalla El-Hadary ◽  
Mahmoud Sitohy
Keyword(s):  
Metabolic Syndrome ◽  
Lipid Metabolism ◽  
Lipolytic Activity ◽  
Control Level ◽  
Serum Triglyceride ◽  
Positive Control ◽  
Lactobacillus Paracasei ◽  
Total Serum ◽  
Albino Rats ◽  
Total Serum Cholesterol

The current study investigates the capacity of a lipolytic Lactobacillus paracasei postbiotic as a possible regulator for lipid metabolism by targeting metabolic syndrome as a possibly safer anti-obesity and Anti-dyslipidemia agent replacing atorvastatin (ATOR) and other drugs with proven or suspected health hazards. The high DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS [2,2′-azino-bis (3-ethyl benzothiazoline-6-sulphonic acid)] scavenging activity and high activities of antioxidant enzyme such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-px) of the Lactobacillus paracasei postbiotic (cell-free extract), coupled with considerable lipolytic activity, may support its action against metabolic syndrome. Lactobacillus paracasei isolate was obtained from an Egyptian cheese sample, identified and used for preparing the postbiotic. The postbiotic was characterized and administered to high-fat diet (HFD) albino rats (100 and 200 mg kg−1) for nine weeks, as compared to atorvastatin (ATOR; 10 mg kg−1). The postbiotic could correct the disruption in lipid metabolism and antioxidant enzymes in HFD rats more effectively than ATOR. The two levels of the postbiotic (100 and 200 mg kg−1) reduced total serum lipids by 29% and 34% and serum triglyceride by 32–45% of the positive control level, compared to only 25% and 35% in ATOR’s case, respectively. Both ATOR and the postbiotic (200 mg kg−1) equally decreased total serum cholesterol by about 40% and 39%, while equally raising HDL levels by 28% and 30% of the positive control. The postbiotic counteracted HFD-induced body weight increases more effectively than ATOR without affecting liver and kidney functions or liver histopathology, at the optimal dose of each. The postbiotic is a safer substitute for ATOR in treating metabolic syndrome.

scholarly journals Evaluation of the hemostatic state, carbohydrate and lipid metabolism in young women with abdominal obesity and hypertension

2015 ◽  
Vol 12 (4) ◽  
pp. 29-33
Author(s):  
Veronika Andreevna Sumerkina ◽  
Vasiliy Sergeevich Chulkov ◽  
Vladislav Sergeevich Chulkov ◽  
Elena Stanislavovna Golovneva ◽  
Larisa Fedorovna Telesheva ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Lipid Metabolism ◽  
Arterial Hypertension ◽  
Total Cholesterol ◽  
Blood Coagulation ◽  
Abdominal Obesity ◽  
Young Women ◽  
The Metabolic Syndrome ◽  
Carbohydrate And Lipid Metabolism ◽  
The Individual

Aim of this study was to determine the characteristics of the laboratory parameters of hemostasis, carbohydrate and lipid metabolism in women with metabolic syndrome, isolated abdominal obesity or with hypertension.Materials and methods. The study included 71 women aged 30 – 44 years and was conducted at laboratory study of hemostasis system, carbohydrate and lipid metabolism.Results. In women with abdominal obesity and arterial hypertension we found an increased levels of glucose, total cholesterol, LDL-C and triglycerides and a decrease in a concentration of HDL-C compared to healthy women. The study of hemostasis revealed prothrombotic changes in the form of activation of coagulation hemostasis and fibrinolysis system activity.Conclusions. The disorders of carbohydrate and lipid metabolism are very prevalent in young women with abdominal obesity and hypertension with every second woman meeting the criteria for the metabolic syndrome. The most pronounced signs of activation of blood coagulation markes was seen in women with abdominal obesity and hypertension. In women with the individual components of the metabolic syndrome there were no significant changes in carbohydrate and lipid metabolism, although we saw an early signs of activation of hemocoagulation.

scholarly journals Monitoring of metabolic syndrome and its main criterions rate in children

2014 ◽  
Vol 18 (3 (71)) ◽  
Author(s):  
N. M. Hromnatska
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Lipid Metabolism ◽  
Arterial Hypertension ◽  
Carbohydrate Metabolism ◽  
Abdominal Obesity ◽  
Metabolic Disorders ◽  
Total Population ◽  
High Density Lipoproteins ◽  
High Concentration

Objective. To study the rate of metabolic syndrome and its main criterions in children.Material and methods. Among 1520 children of total population 90 children with metabolic syndrome aged from 9 to 18 years were selected. Diagnosing of metabolic syndrome was provided according to International Diabetic Federation recommendations (2007).Results. It was established that the rate of metabolic syndrome in children of Lviv was 5,9%. The most spread and therefore primary criterion of metabolic syndrome in children was abdominal obesity, which was diagnosed both in overweight (36,6%) and in generalized obesity (63,4) (p=0,039) and was identified in all children with metabolic syndrome (100,0%). Insulin resistance as a sign of carbohydrate metabolism changes was identified in fewer children (41,8%), which means the primacy of abdominal obesity in relation to insulin resistance in metabolic syndrome criterions formation. Hyperglycemia and hypoalphacholesterolemia were almost of the same frequency, which suggests the likelihood of metabolic syndrome development both toward carbohydrate metabolism changes with hyperinsulinemia and hyperglycemia and to lipid metabolism with lowered cholesterol level in high density lipoproteins as well as to hypertriglyceridemia. The latter had the lowest diagnostic level (18,8%).Summary. The rate of metabolic syndrome and its main criterions in Lviv children did not differ from the universal rate. The most informative and spread metabolic syndrome criterions in descending order were: abdominal obesity → arterial hypertension→ hyperinsulinemia → insulin resistance →hyperglycemia→low concentrarion of high-densitycholesterol→high concentration of triglycerides in blood. It is rational to monitor metabolic syndrome in Ukraine, whichreflects a real spread of metabolic disorders in order to prevent and correction them.

Influence of L-arginine on the Heart Histology and Function Markers of Metabolic Syndrome in Female Wistar Albino Rats

2013 ◽  
Vol 13 (4) ◽  
pp. 276-282
Author(s):  
Anthony C.C. Egbuonu ◽  
Ifeoma I. Ijeh ◽  
Lawrence U.S. Ezeanyika ◽  
Onyechi O. Obidoa
Keyword(s):  
Metabolic Syndrome ◽  
Albino Rats ◽  
Wistar Albino Rats ◽  
And Function
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