Index of Multiple Deprivation Contributed to Common Psychiatric Disorders: An Observational and Genome-Wide Gene-Environment Interaction Analysis in UK Biobank Cohort

2021 ◽  
Author(s):  
Xin Qi ◽  
Chuyu Pan ◽  
Yan Wen ◽  
Li Liu ◽  
Bolun Cheng ◽  
...  
Keyword(s):  
Psychiatric Disorders ◽  
Interaction Analysis ◽  
Environment Interaction ◽  
Uk Biobank ◽  
Multiple Deprivation ◽  
Gene Environment Interaction ◽  
Gene Environment ◽  
Genome Wide ◽  
Index Of Multiple Deprivation

scholarly journals The effects of polygenic risk for psychiatric disorders and smoking behaviour on psychotic experiences in UK Biobank

2019 ◽  
Author(s):  
Judit García-González ◽  
Julia Ramírez ◽  
David M. Howard ◽  
Caroline H Brennan ◽  
Patricia B. Munroe ◽  
...  
Keyword(s):  
Psychiatric Disorders ◽  
Genetic Risk ◽  
Maternal Smoking ◽  
Smoking Status ◽  
Smoking Behaviour ◽  
Environment Interaction ◽  
Uk Biobank ◽  
Psychotic Experiences ◽  
Gene Environment Interaction ◽  
Gene Environment

ABSTRACTWhile psychotic experiences are core symptoms of mental health disorders like schizophrenia, they are also reported by 5-10% of the population. Both smoking behaviour and genetic risk for psychiatric disorders have been associated with psychotic experiences, but the interplay between these factors remains poorly understood. We tested whether smoking status, maternal smoking around birth, and number of packs smoked/year were associated with lifetime occurrence of three psychotic experiences phenotypes: delusions (n=2067), hallucinations (n=6689), and any psychotic experience (delusions or hallucinations; n=7803) in 144818 UK Biobank participants. We next calculated polygenic risk scores for schizophrenia (PRSSCZ), major depression (PRSDEP) and attention deficit hyperactivity disorder (PRSADHD) in the UK Biobank participants to assess whether association between smoking and psychotic experiences was attenuated after adjustment of diagnosis of psychiatric disorders and the PRSs. Finally, we investigated whether smoking exacerbates the effects of genetic predisposition on the psychotic phenotypes in gene-environment interaction models. Smoking status, maternal smoking, and number of packs smoked/year were significantly associated with psychotic experiences (p<1.77×10−5). Except for packs smoked/year, effects were attenuated but remained significant after adjustment for diagnosis of psychiatric disorders and PRSs (p<1.99×10−3). Gene-environment interaction models showed the effects of PRSDEP and PRSADHD(but not PRSSCZ) on delusions (but not hallucinations) were significantly greater in current smokers compared to never smokers (p<0.0028). There were no significant gene-environment interactions for maternal smoking nor for number of packs smoked/year. Our results suggest that both genetic risk of psychiatric disorders and smoking status may have independent and synergistic effects on specific types of psychotic experiences.

scholarly journals Genome-wide gene–environment interaction analysis for asbestos exposure in lung cancer susceptibility

2012 ◽  
Vol 33 (8) ◽  
pp. 1531-1537 ◽  
Author(s):  
Sheng Wei ◽  
Li-E Wang ◽  
Michelle K. McHugh ◽  
Younghun Han ◽  
Momiao Xiong ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Susceptibility ◽  
Interaction Analysis ◽  
Asbestos Exposure ◽  
Environment Interaction ◽  
Gene Environment Interaction ◽  
Gene Environment ◽  
Genome Wide ◽  
Lung Cancer Susceptibility

scholarly journals Haplotype and Haplotype-Environment Interaction Analysis Revealed Roles of SPRY2 for NSCL/P among Chinese Populations

2019 ◽  
Vol 16 (4) ◽  
pp. 557 ◽  
Author(s):  
Ren Zhou ◽  
Mengying Wang ◽  
Wenyong Li ◽  
Siyue Wang ◽  
Hongchen Zheng ◽  
...  
Keyword(s):  
Interaction Analysis ◽  
Genome Wide Association ◽  
Environment Interaction ◽  
Genome Wide Association Studies ◽  
Gene Effects ◽  
Multivitamin Supplementation ◽  
Chinese Populations ◽  
Gene Environment Interaction ◽  
Gene Environment ◽  
Genome Wide

Non-syndromic cleft lip with or without cleft palate (NSCL/P) is one of common birth defects in China, with genetic and environmental components contributing to the etiology. Genome wide association studies (GWASs) have identified SPRY1 and SPRY2 to be associated with NSCL/P among Chinese populations. This study aimed to further explore potential genetic effect and gene—environment interaction among SPRY genes based on haplotype analysis, using 806 Chinese case—parent NSCL/P trios drawn from an international consortium which conducted a genome-wide association study. After the process of quality control, 190 single nucleotide polymorphisms (SNPs) of SPRY genes were included for analyses. Haplotype and haplotype—environment interaction analyses were conducted in Population-Based Association Test (PBAT) software. A 2-SNP haplotype and three 3-SNP haplotypes showed a significant association with the risk of NSCL/P after Bonferroni correction (corrected significance level = 2.6 × 10−4). Moreover, haplotype—environment interaction analysis identified these haplotypes respectively showing statistically significant interactions with maternal multivitamin supplementation or maternal environmental tobacco smoke. This study showed SPRY2 to be associated with NSCL/P among the Chinese population through not only gene effects, but also a gene—environment interaction, highlighting the importance of considering environmental exposures in the genetic etiological study of NSCL/P.

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