miR-150-3p Enhances Neuroprotective Effects of Neural Stem Cell Exosomes after Hypoxic-Ischemic Brain Injury by Targeting CASP2

2021 ◽  
Author(s):  
hongcheng Luo ◽  
Guangbin Ye ◽  
Yu Liu ◽  
Deyou Huang ◽  
Qisheng Luo ◽  
...  
Keyword(s):  
Stem Cell ◽  
Brain Injury ◽  
Neural Stem Cell ◽  
Ischemic Brain Injury ◽  
Neuroprotective Effects ◽  
Ischemic Brain ◽  
Hypoxic Ischemic Brain Injury

scholarly journals Previous Adaptation Period Modulates Pregnancy Swimming Neuroprotective Effects on the Offspring Following Neonatal Hypoxic‐Ischemic Brain Injury

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Isadora Davila Tassinari ◽  
Eduardo Farias Sanches ◽  
Rafael Bandeira Fabres ◽  
Mirella Kielek Galvan Andrade ◽  
Thais Lopes Rodrigues ◽  
...  
Keyword(s):  
Brain Injury ◽  
Ischemic Brain Injury ◽  
Adaptation Period ◽  
Neuroprotective Effects ◽  
Ischemic Brain ◽  
Hypoxic Ischemic Brain Injury

scholarly journals Neuroactive Steroids in Hypoxic–Ischemic Brain Injury: Overview and Future Directions

2020 ◽  
Author(s):  
Nicolas Toro-Urrego ◽  
Marco Avila-Rodriguez ◽  
María Inés Herrera ◽  
Andrea Aguilar ◽  
Lucas Udovin ◽  
...  
Keyword(s):  
Brain Injury ◽  
Estrogenic Activity ◽  
Neuroactive Steroids ◽  
Ischemic Brain Injury ◽  
Neuroprotective Effects ◽  
Future Directions ◽  
Ischemic Brain ◽  
Public Health Burden ◽  
Hypoxic Ischemic Brain Injury ◽  
Underlying Mechanisms

Hypoxic–ischemic brain injury is a number one cause of long-term neurologic disability and death worldwide. This public health burden is mainly characterized by a decrease in oxygen concentration and blood flow to the tissues, which lead to an inefficient supply of nutrients to the brain. This condition induces cell death by energy depletion and increases free radical generation and inflammation. Hypoxic–ischemic brain injury may occur in ischemic-stroke and over perinatal asphyxia, being both leading causes of morbidity in adults and children, respectively. Currently, there are no effective pharmaceutical strategies to prevent the triggering of secondary injury cascades, including oxidative stress and metabolic dysfunction. Neuroactive steroids like selective estrogen receptor modulators, SERMs, and selective tissue estrogenic activity regulators, STEARs, exert several neuroprotective effects. These encompass mitochondrial survival, a decrease in reactive oxygen species, and maintenance of cell viability, among others. In this context, these neurosteroids constitute promising molecules, which could modify brain response to injury. Here we show an updated overview of the underlying mechanisms of hypoxic–ischemic brain injury. We also highlight the neuroprotective effects of neurosteroids and their future directions.

Neuroprotective Effects of AG490 in Neonatal Hypoxic-Ischemic Brain Injury

2019 ◽  
Vol 56 (12) ◽  
pp. 8109-8123 ◽  
Author(s):  
Feiya Li ◽  
Raymond Wong ◽  
Zhengwei Luo ◽  
Lida Du ◽  
Ekaterina Turlova ◽  
...  
Keyword(s):  
Brain Injury ◽  
Ischemic Brain Injury ◽  
Neuroprotective Effects ◽  
Ischemic Brain ◽  
Hypoxic Ischemic Brain Injury

scholarly journals Neuroprotective effects of inter-alpha inhibitor proteins after hypoxic-ischemic brain injury in neonatal rats

2019 ◽  
Vol 317 ◽  
pp. 244-259 ◽  
Author(s):  
Xiaodi Chen ◽  
Sakura Nakada ◽  
John E. Donahue ◽  
Ray H. Chen ◽  
Richard Tucker ◽  
...  
Keyword(s):  
Brain Injury ◽  
Ischemic Brain Injury ◽  
Neonatal Rats ◽  
Neuroprotective Effects ◽  
Ischemic Brain ◽  
Hypoxic Ischemic Brain Injury
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