Biological Functions and Prognostic Value of RNA Modification Patterns Associated with Tumor Microenvironment Immune Infiltration in Testicular Germ Cell Tumor

2021 ◽  
Author(s):  
Jiajin Wu ◽  
Jiajun Xing ◽  
Linghui Liang ◽  
Zhongyuan Wang ◽  
Songbo Wang ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Germ Cell ◽  
Germ Cell Tumor ◽  
Prognostic Value ◽  
Testicular Germ Cell Tumor ◽  
Cell Tumor ◽  
Rna Modification ◽  
Biological Functions ◽  
Testicular Germ Cell ◽  
Immune Infiltration

scholarly journals Microsatellite instability and loss of heterozygosity have distinct prognostic value for testicular germ cell tumor recurrence

2004 ◽  
Vol 3 (11) ◽  
pp. 1152-1158 ◽  
Author(s):  
Alfredo Velasco ◽  
Erick Riquelme ◽  
Marcela Schultz ◽  
Ignacio I. Wistuba ◽  
Luis Villarroel ◽  
...  
Keyword(s):  
Germ Cell ◽  
Microsatellite Instability ◽  
Loss Of Heterozygosity ◽  
Germ Cell Tumor ◽  
Prognostic Value ◽  
Tumor Recurrence ◽  
Testicular Germ Cell Tumor ◽  
Cell Tumor ◽  
Testicular Germ Cell

scholarly journals Prognostic value of CD66b positive tumor-infiltrating neutrophils in testicular germ cell tumor

BMC Cancer ◽  
2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Yuta Yamada ◽  
Tohru Nakagawa ◽  
Toru Sugihara ◽  
Takamasa Horiuchi ◽  
Uran Yoshizaki ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Prognostic Value ◽  
Testicular Germ Cell Tumor ◽  
Cell Tumor ◽  
Testicular Germ Cell

scholarly journals Prognostic value of serum carbonic anhydrase IX in testicular germ cell tumor patients

2016 ◽  
Vol 12 (4) ◽  
pp. 2590-2598 ◽  
Author(s):  
Katarina Kalavska ◽  
Michal Chovanec ◽  
Miriam Zatovicova ◽  
Martina Takacova ◽  
Paulina Gronesova ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Germ Cell ◽  
Germ Cell Tumor ◽  
Prognostic Value ◽  
Testicular Germ Cell Tumor ◽  
Cell Tumor ◽  
Carbonic Anhydrase Ix ◽  
Tumor Patients ◽  
Testicular Germ Cell

Testicular germ cell tumor with pineal metastases

Neurosurgery ◽  
1990 ◽  
pp. 688 ◽  
Author(s):  
B Delahunt ◽  
H H Teoh ◽  
V Balakrishnan ◽  
J N Nacey ◽  
S P Clark
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Testicular Germ Cell Tumor ◽  
Cell Tumor ◽  
Testicular Germ Cell

666 A NOVEL RISK STRATIFICATION SYSTEM FOR CHEMOTHERAPY FAILURE IN TESTICULAR GERM CELL TUMOR

2012 ◽  
Vol 187 (4S) ◽  
Author(s):  
Jessica Lubahn ◽  
Nicholas Cost ◽  
Mehrad Adibi ◽  
Adam Romman ◽  
Ganesh Raj ◽  
...  
Keyword(s):  
Risk Stratification ◽  
Germ Cell ◽  
Germ Cell Tumor ◽  
Testicular Germ Cell Tumor ◽  
Cell Tumor ◽  
Testicular Germ Cell ◽  
Stratification System ◽  
Risk Stratification System

scholarly journals A second independent locus within DMRT1 is associated with testicular germ cell tumor susceptibility

2011 ◽  
Vol 20 (15) ◽  
pp. 3109-3117 ◽  
Author(s):  
Peter A. Kanetsky ◽  
Nandita Mitra ◽  
Saran Vardhanabhuti ◽  
David J. Vaughn ◽  
Mingyao Li ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Testicular Germ Cell Tumor ◽  
Cell Tumor ◽  
Testicular Germ Cell ◽  
Tumor Susceptibility ◽  
Independent Locus

scholarly journals The overexpression of SOX2 affects the migration of human teratocarcinoma cell line NT2/D1

2015 ◽  
Vol 87 (1) ◽  
pp. 389-404 ◽  
Author(s):  
DANIJELA DRAKULIC ◽  
JELENA MARJANOVIC VICENTIC ◽  
MARIJA SCHWIRTLICH ◽  
JELENA TOSIC ◽  
ALEKSANDAR KRSTIC ◽  
...  
Keyword(s):  
Stem Cells ◽  
Tumor Suppressor ◽  
Cancer Stem Cells ◽  
Germ Cell ◽  
Germ Cell Tumor ◽  
Testicular Germ Cell Tumor ◽  
Cell Tumor ◽  
Testicular Germ Cell ◽  
Teratocarcinoma Cell ◽  
Altered Expression

The altered expression of the SOX2 transcription factor is associated with oncogenic or tumor suppressor functions in human cancers. This factor regulates the migration and invasion of different cancer cells. In this study we investigated the effect of constitutive SOX2 overexpression on the migration and adhesion capacity of embryonal teratocarcinoma NT2/D1 cells derived from a metastasis of a human testicular germ cell tumor. We detected that increased SOX2 expression changed the speed, mode and path of cell migration, but not the adhesion ability of NT2/D1 cells. Additionally, we demonstrated that SOX2 overexpression increased the expression of the tumor suppressor protein p53 and the HDM2 oncogene. Our results contribute to the better understanding of the effect of SOX2 on the behavior of tumor cells originating from a human testicular germ cell tumor. Considering that NT2/D1 cells resemble cancer stem cells in many features, our results could contribute to the elucidation of the role of SOX2 in cancer stem cells behavior and the process of metastasis.

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