IL-9 Producing Tumor-Infiltrating Lymphocytes (Til) and Treg Subsets Drive Immune Escape of Tumor Cells in Non-Small Cell Lung Cancer

2021 ◽  
Author(s):  
Lisanne Heim ◽  
Mircea T. Chiriac ◽  
Katerina Kachler ◽  
Sarah Mitsch ◽  
Zuqin Yang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Tumor Cells ◽  
Cell Lung Cancer ◽  
Immune Escape ◽  
Tumor Infiltrating Lymphocytes ◽  
Small Cell ◽  
Small Cell Lung ◽  
Infiltrating Lymphocytes

Correlation of β-catenin expression in non-small cell lung cancer to prognosis and CD8 positive cells infiltration.

2018 ◽  
Vol 36 (5_suppl) ◽  
pp. 142-142
Author(s):  
Satoshi Muto ◽  
Yuki Ozaki ◽  
Takuya Inoue ◽  
Takumi Yamaura ◽  
Mitsuro Fukuhara ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Tumor Cells ◽  
Cell Lung Cancer ◽  
Progression Free Survival ◽  
Tumor Infiltrating Lymphocytes ◽  
Small Cell ◽  
Rank Test ◽  
Small Cell Lung ◽  
Infiltrating Lymphocytes

142 Background: It was reported that β-catenin expression in tumor cells suppresses dendritic cell infiltration into tumor in mouse model of melanoma. It results in less of tumor infiltrating lymphocytes. In non-small cell lung cancer (NSCLC), it is not well understood that β-catenin is involved in cancer immunity in that context. Methods: We studied the association between β-catenin expression and CD8 positive cells infiltration in NSCLC. Ninety-one patients with NSCLC who had complete surgical resection during January 2013 to June 2015 were subjected. β-catenin expression of tumor cells and CD8 positive cells infiltration were analyzed by immunohistochemistry. Survival analysis including over-all survival (OS) and progression-free survival (PFS) were also statistically examined by log-rank test. Results: Fourteen cases (15%) were β-catenin positive. Among 14 β-catenin positive cases, only 2 cases (14%) had CD8 positive cells infiltration. Seventy-five cases (97%) had CD8 positive cells infiltration in β-catenin negative tumors (p < 0.01). Squamous cell carcinoma was relatively higher level of expression than others (44% vs. 9%) and mean primary tumor size was larger in β-catenin positive tumors (3.6 cm) than those in negative tumors (2.7 cm). Median OS was 43.8 months and median PFS was 37.0 months in β-catenin positive group. They were not reached in β-catenin negative group. Both OS and PFS were shorter in β-catenin positive cases (p < 0.01). Conclusions: In NSCLC, β-catenin expression was negatively associated with CD8 positive cells infiltration and poor prognosis. We furthermore will focus on the association between β-catenin expression in tumor and clinical efficacy or resistant mechanism of immune checkpoint blockades.

scholarly journals The Role of Tumor-Infiltrating Lymphocytes in Development, Progression, and Prognosis of Non–Small Cell Lung Cancer

2016 ◽  
Vol 11 (6) ◽  
pp. 789-800 ◽  
Author(s):  
Roy M. Bremnes ◽  
Lill-Tove Busund ◽  
Thomas L. Kilvær ◽  
Sigve Andersen ◽  
Elin Richardsen ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Tumor Infiltrating Lymphocytes ◽  
Small Cell ◽  
Small Cell Lung ◽  
Infiltrating Lymphocytes
Sign in / Sign up

Export Citation Format

Share Document