Integrated Osteochondral Microsphere Scaffolds with Biomimetic Architecture and Regional Vascularization for Joint Repair

2021 ◽  
Author(s):  
Xiang Gu ◽  
Yao Zha ◽  
Yawu Li ◽  
Jia Chen ◽  
Shuaibing Liu ◽  
...  
Keyword(s):  
Joint Repair

Microfracture for the Treatment of Symptomatic Cartilage Lesions of the Knee: A Survey of International Cartilage Regeneration & Joint Preservation Society

Cartilage ◽  
2020 ◽  
pp. 194760352095450
Author(s):  
Jesus Medina ◽  
Ignacio Garcia-Mansilla ◽  
Peter D. Fabricant ◽  
Thomas J. Kremen ◽  
Seth L. Sherman ◽  
...  
Keyword(s):  
Surgical Technique ◽  
Regional Differences ◽  
Current Practice ◽  
Cartilage Regeneration ◽  
Postoperative Management ◽  
Cartilage Lesions ◽  
Significant Difference ◽  
Rehabilitation Protocols ◽  
Joint Repair ◽  
Vertical Walls

Objective The purpose of this study was to describe the current practice trends for managing symptomatic cartilage lesions of the knee with microfracture among ICRS (International Cartilage Regeneration & Joint Repair Society) members. Design A 42-item electronic questionnaire was sent to all ICRS members, which explored indications, surgical technique, postoperative management, and outcomes of the microfracture procedure for the treatment of symptomatic, full thickness chondral and osteochondral defects of the knee. Responses were compared between surgeons from different regions and years of practice. Results A total of 385 surgeons answered the questionnaire. There was a significant difference noted in the use of microfracture among surgeons by region ( P < 0.001). There was no association between the number of years in practice and the self-reported proportion of microfracture cases performed ( P = 0.37). Fifty-eight subjects (15%) indicated that they do not perform microfracture at all. Regarding indication for surgery, 56% of surgeons would limit their indication of microfracture to lesions measuring 2 cm2 or less. Half of the surgeons reported no upper age or body mass index limit. Regarding surgical technique, 90% of surgeons would recommend a formal debridement of the calcified layer and 91% believe it is important to create stable vertical walls. Overall, 47% of surgeons use biologic augmentation, with no significant difference between regions ( P = 0.35) or years of practice ( P = 0.67). Rehabilitation protocols varied widely among surgeons. Conclusions Indications, operative technique, and rehabilitation protocols utilized for patients undergoing microfracture procedures vary widely among ICRS members. Regional differences and resources likely contribute to these practice pattern variations.

scholarly journals Tissue engineering osteochondral implants for temporomandibular joint repair

2005 ◽  
Vol 8 (4) ◽  
pp. 313-319 ◽  
Author(s):  
RM Schek ◽  
JM Taboas ◽  
SJ Hollister ◽  
PH Krebsbach
Keyword(s):  
Tissue Engineering ◽  
Temporomandibular Joint ◽  
Joint Repair

Autologous Oxygen-Releasing Nano-Biomimetic Scaffold with Chondrocytes Promotes Joint Repair After Trauma

2022 ◽  
Vol 12 (3) ◽  
pp. 602-608
Author(s):  
Wuping Yao ◽  
Yuji Li ◽  
Zhi Liu ◽  
Liuyi Yao ◽  
Rui Liang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Composite Scaffold ◽  
Control Group ◽  
Tunel Staining ◽  
Osteochondral Fracture ◽  
Patellar Cartilage ◽  
Significant Difference ◽  
Biomimetic Scaffold ◽  
Joint Repair ◽  
Osteochondral Fractures

Our study assesses the role of a scaffold constructed by co-culture of autologous oxygen-releasing biomimetic scaffold (AONS) and chondrocytes in joint repair after trauma. A composite scaffold structure was used and a scaffold constructed of AONS and chondrocytes was transplanted into SD rats to create models of patellar cartilage fracture and hip osteochondral fracture, respectively followed by analysis of cell proliferation by immunofluorescence method, osteogenesis-related gene expression by RT-PCR, chondrocytes apoptosis by TUNEL staining. The blank control group and AONS composite chondrocytes have significant differences in apoptosis and cell proliferation of two fracture types (P <0.05). The autologous oxygen-releasing nanometers at 4 and 8 weeks showed a significant difference in the number of PCNA and TUNEL cells between biomimetic scaffold and chondrocytes in two groups (P < 0.05). The AONS and chondrocytes were effective for two types of fractures at 1, 4 and 8 weeks. The expression of various markers of intrachondral osteogenesis was decreased and the markers of hip osteochondral fracture were increased significantly (P < 0.05). Joint recovery was better than patellar cartilage fractures. The AONS composite chondrocyte scaffold promotes repair of patellar cartilage fractures and hip osteochondral fractures with a better effect on hip osteochondral fractures.

dGEMRIC MAPPING OF KNEE JOINT REPAIR

2014 ◽  
pp. 177-195
Author(s):  
GOETZ H. WELSCH ◽  
FRIEDRICH F. HENNIG ◽  
ANDREAS MAUERER ◽  
SIEGFRIED TRATTNIG
Keyword(s):  
Knee Joint ◽  
Joint Repair

MORPHOLOGICAL IMAGING OF JOINT REPAIR

2014 ◽  
pp. 51-108
Author(s):  
EDWIN H. G. OEI ◽  
STEPHEN J. MATZAT ◽  
GARRY E. GOLD
Keyword(s):  
Joint Repair

Structural, technological and Aesthetical Considerations for the Detailing of Steel Tubular Joints

2018 ◽  
Author(s):  
Vasil Georgiev Georgiev ◽  
Dimitar Dakov ◽  
Yavor Mihov
Keyword(s):  
Fatigue Strength ◽  
Stress Concentration ◽  
Civil Engineering ◽  
Fatigue Cracks ◽  
High Stress ◽  
Traffic Sign ◽  
Tubular Joints ◽  
Joint Repair ◽  
Tubular Joint ◽  
Supporting Structures

<p>For the majority of steel outdoor facilities (towers, masts, billboards and traffic-sign supporting structures) wind loading is the governing factor for determining their resistance and stiffness. In many cases fatigue-related issues appear, with cracking and failure in the welded connections of tubular joints or in the parent metal adjacent to the welds.</p><p>Structural detailing of the joints in steel tubular structures subjected to repeated cyclic loading is of great importance for their fatigue strength. Sharp changes in the shape, sharp turns in the welds and notches give rise to high stress concentration. The combined effect of discontinuities and stress concentration is the main cause for the formation and propagation of fatigue cracks. When detailing the erection joints it is also necessary to observe technological requirements related to efficiency of fabrication. For the civil engineering works exposed to public it is indispensable to include additional requirements for the aesthetic appearance of their visible structural parts. The design experience shows that applying aesthetic considerations to steel tubular joint detailing may contribute to satisfying the increased fatigue strength requirements.</p><p>The paper presents a study on the wind action on a specific kind of civil engineering works (traffic- sign supporting structures) and the approach used for its determination. The leading structural, technological and aesthetic criteria to be implemented in the detailing of tubular erection joints are formulated. An example of tubular joint destroyed due to propagation of fatigue crack is given and possible options for the joint repair are proposed. Numerical modeling and analyses of the original and repaired joints have been carried out in order to make conclusions for the advantages and shortcomings of the joint repair options.</p>

Sign in / Sign up

Export Citation Format

Share Document