Comparative Degradation Study of Free-Run Rosé Wine Under Accelerated and Typical Storage Conditions and the Influence of Antique Green and Flint Glass Bottles

2021 ◽  
Author(s):  
Jonathan Fernández de Ara ◽  
Eluxka Almandoz ◽  
Beatriz Navarcorena ◽  
Jennifer Moriones ◽  
Pablo Amézqueta ◽  
...  
Keyword(s):  
Storage Conditions ◽  
Degradation Study ◽  
Flint Glass ◽  
Glass Bottles ◽  
Rosé Wine

Comparative Degradation Study of Free-Run Rosé Wine Under Accelerated and Typical Storage Conditions and the Influence of Antique Green and Flint Glass Bottles

2021 ◽  
Author(s):  
Jonathan Fernández de Ara ◽  
Eluxka Almandoz ◽  
Beatriz Navarcorena ◽  
Jennifer Moriones ◽  
Pablo Amézqueta ◽  
...  
Keyword(s):  
Storage Conditions ◽  
Degradation Study ◽  
Flint Glass ◽  
Glass Bottles ◽  
Rosé Wine

scholarly journals Preparation of Myrica nagi (Box myrtle) drink and effect of storage temperature on its quality

2017 ◽  
Vol 9 (4) ◽  
pp. 2137-2142
Author(s):  
Abhimanyu Thakur ◽  
N. S. Thakur ◽  
Pradeep Kumar
Keyword(s):  
Storage Temperature ◽  
Titratable Acidity ◽  
Storage Conditions ◽  
Quality Characteristics ◽  
Soluble Solids ◽  
Ambient Conditions ◽  
Physico Chemical ◽  
Glass Bottles ◽  
Myrica Nagi ◽  
Polyethylene Terephthalate Bottles

Box myrtle (Myrica nagi) belongs to family Myricaceae is a sub-temperate tree found throughout the mid-Himalayas at an elevation of 1300 to 2100 meters above mean sea level. Its fruits are known for their ravishing taste and have been reported as rich source of anti-oxidants like phenols and anthocyanins. In the present study drink was prepared from box myrtle juice and quality evaluation was carried out during six months of storage of fruit drink. Different combinations of juice (8%, 10%, 12%, 14% and 16 %) and sugar syrup/TSS (Total soluble solids) (12 oB and 15 oB) were tried to standardize proper combination for drink. The drink prepared by following the best selected recipe (14 % juice and 12 oB TSS) was packed in glass and PET (Polyethylene terephthalate) bottles and stored for six months under ambient and refrigerated temperature conditions. Drink could be safely stored for a period of six months under both the storage conditions without much change in various quality characteristics. Various physico-chemical characteristics increased/decreased like TSS (12.05 to 12.48 oB), reducing sugars (7.80 to 8.69 %), titratable acidity (0.30 to 0.27 %), ascorbic acid (1.09 to 0.47 mg/100 g), total phenols (27.35 to 19.11 mg/100 g) and anthocyanins (6.14 to 3.69 mg/100 g). However, the changes in the quality characteristics of the drink were slower in refrigerated storage conditions as compared to ambient conditions. Both the packaging materials viz. PET and glass bottles were found suitable, with comparatively less changes occurring in glass bottles stored under refrigerated conditions.

Adsorption of 2,4-Dichlorophenoxyacetic Acid on Glassware as Source of Error in 2,4-D Analysis

1982 ◽  
Vol 65 (3) ◽  
pp. 763-765
Author(s):  
Gordon Y P Kan ◽  
Fred T S Mah ◽  
Norman L Wade
Keyword(s):  
Methylene Chloride ◽  
Dichlorophenoxyacetic Acid ◽  
Glass Vessel ◽  
Flint Glass ◽  
Glass Bottles ◽  
2,4 Dichlorophenoxyacetic Acid ◽  
Source Of Error

Abstract Loss of 2,4-dichlorophenoxyacetic acid (2,4-D) by adsorption on Pyrex evaporating flasks and flint glass bottles was studied. 2,4-D may be quantitatively recovered by direct methylation with diazomethane in Pyrex evaporating flasks; it may also be desorbed with methylene chloride in the presence of strong H2SO4. This step must be taken when 2,4-D is transferred from one glass vessel to another to ensure accuracy of data.

scholarly journals Identification of degradation impurity of TGR5 receptor agonist-ZY12201 by LC–MS technique during force degradation study

2021 ◽  
Vol 3 (6) ◽  
Author(s):  
Chandrakant Sojitra ◽  
Chintan Dholakia ◽  
Padmaja Sudhakar ◽  
Kumar K. Singh ◽  
Sameer Agarwal
Keyword(s):  
Degradation Products ◽  
Oxidative Degradation ◽  
Active Pharmaceutical Ingredient ◽  
Storage Conditions ◽  
Receptor Activation ◽  
Degradation Pathway ◽  
Forced Degradation ◽  
Degradation Study ◽  
Glucagon Like Peptide 1 ◽  
Orally Bioavailable

AbstractForced degradation study is a systemic characterization of degradation products of active pharmaceutical ingredient (API) at conditions which posses more harsh environment that accelerates degradation of API. Forced degradation and stability studies would be useful in selection of proper, packaging material and storage conditions of the API. These are also useful to demonstrate degradation pathways and degradation products of the API and further characterisation of the degradation products using mass spectrometry. TGR5 is a G protein-coupled receptor, activation of which promotes secretion of glucagon-like peptide-1 (GLP-1) and modulates insulin secretion. The potent and orally bioavailable TGR5 agonist, ZY12201, shows activation of TGR5 which increase secretion of GLP-1 and help in lowering blood glucose level in animal models. Hence it is necessary to establish and study degradation pathway and stability of API for better handling and regulatory approval. Force degradation studies of ZY12201 have shown presence of one oxidative impurity during oxidative degradation in HPLC analysis. The oxidized product is further characterized by LC–MS to elucidate structure of impurity and characterize its degradation pathway.

scholarly journals FORCED DEGRADATION STUDY OF STATINS: A REVIEW

2018 ◽  
Vol 10 (6) ◽  
pp. 38
Author(s):  
Rini Yulianita ◽  
Iyan Sopyan ◽  
Muchtaridi Muchtaridi
Keyword(s):  
Degradation Products ◽  
Storage Conditions ◽  
Lipid Lowering ◽  
Forced Degradation ◽  
Degradation Study ◽  
Drug Degradation ◽  
Drug Products ◽  
Drug Substances ◽  
Accelerated Stability ◽  
Forced Degradation Studies

Forced degradation study is the degradation of new drug substances and drug products in more severe conditions than accelerated conditions. Forced degradation study were conducted to demonstrate the specificity of stability-indicating methods, providing insight into degradation pathways and drug degradation products, assisting in the elucidation of degradation product structures, identifying degradation products that could be spontaneously generated during storage and use of drugs and to facilitate improvement in manufacturing process and formulation corresponding with accelerated stability studies. Statins, a class of lipid-lowering medications, are the most widely prescribed drugs and an example of an unstable drug. Statins are susceptible to hydrolysis in the presence of high temperatures and humidity. Therefore, the review discusses various studies of forced degradation studies in six statins drug (atorvastatin, fluvastatin, pitavastatin, pravastatin, rosuvastatin, and simvastatin) to describe the drug's intrinsic stability thus it can assist the selection of formulations and packaging as well as proper storage conditions.

scholarly journals Activity of two natural additives in improving the stability of virgin olive oil quality during storage

OCL ◽  
2020 ◽  
Vol 27 ◽  
pp. 44
Author(s):  
Mohamed El Yamani ◽  
El Hassan Sakar ◽  
Abdelali Boussakouran ◽  
Yahia Rharrabti
Keyword(s):  
Olive Oil ◽  
Storage Time ◽  
Oil Quality ◽  
Virgin Olive Oil ◽  
Principal Component ◽  
Storage Conditions ◽  
Oxidation Products ◽  
Glass Bottles ◽  
The Impact ◽  
Natural Additives

The activity of natural additives against the deterioration of virgin olive oil (VOO) in relation to storage time and conditions was examined. Thus, carotenoids and phenols previously extracted from carrot and olive mill wastewater, respectively, were added at 200 and 400 ppm to VOO and stored in clear and amber glass bottles at room temperatures during 120 days. The results showed that enriched VOO was largely influenced by the storage time, which resulted in a significant accumulation of hydrolysis and oxidation products. Storage conditions also affected considerably the enriched VOO. Dark glass bottles offered better protection against oxidative deterioration. The impact of both extracts on the oxidation status of examined VOO was significant and concentration-dependent. The natural additives markedly delayed the formation of hydroperoxides and conjugated dienes and trienes. Results from principal component analysis (PCA) showed that most of the variation was captured by the PC1 (89% of the total variance) which grouped samples in four categories according to storage times, each being divided into two clusters linked to storage conditions. Findings from this study revealed that natural additives could minimize VOO deterioration caused by storage time and conditions (light).

Effect of Storage Conditions on the Biological Activity of Phenolic Compounds of Blueberry Extract Packed in Glass Bottles

2007 ◽  
Vol 55 (7) ◽  
pp. 2705-2713 ◽  
Author(s):  
Anita Srivastava ◽  
Casimir C. Akoh ◽  
Weiguang Yi ◽  
Joan Fischer ◽  
Gerard Krewer
Keyword(s):  
Biological Activity ◽  
Phenolic Compounds ◽  
Storage Conditions ◽  
Glass Bottles

Compatibility of Clindamycin Phosphate with Amikacin Sulfate at Room Temperature and with Gentamicin Sulfate and Tobramycin Sulfate under Frozen Conditions

1986 ◽  
Vol 20 (12) ◽  
pp. 960-963 ◽  
Author(s):  
Dwight A. Marble ◽  
John A. Bosso ◽  
Raymond J. Townsend
Keyword(s):  
Room Temperature ◽  
Storage Conditions ◽  
Phosphate Solution ◽  
Clindamycin Phosphate ◽  
Antibiotic Concentration ◽  
Gentamicin Sulfate ◽  
Plastic Bags ◽  
Glass Bottles ◽  
Amikacin Sulfate ◽  
Tobramycin Sulfate

The stability and compatibility of clindamycin phosphate with three aminoglycosides, amikacin sulfate, tobramycin sulfate, and gentamicin sulfate, admixed in either glass bottles or plastic bags, were studied under various storage conditions. In addition to the various two-drug combinations, each antibiotic was studied alone in the same solutions under the same storage conditions investigated for the various combinations. Clindamycin phosphate was admixed with amikacin sulfate in 100 ml glass bottles of both dextrose 5% in water (D5W) and NaCl 0.9%. The resultant solutions were examined for visual clarity; both pH and antibiotic concentrations were measured at the time of mixing and at 1, 4, 8, 12, 24, and 48 hours later. The solutions were maintained at room temperature under ambient lighting conditions throughout the observation period. Clindamycin phosphate was also admixed with tobramycin sulfate and gentamicin sulfate, in separate experiments, in 50 ml plastic bags of D5W and NaCl 0.9%. These solutions were examined, at the time of mixing, for visual clarity, pH, and antibiotic concentration and then frozen at −20°C. They were thawed 14 and 28 days later and reexamined. Clindamycin phosphate concentrations were measured by high performance liquid chromatography; those of the aminoglycosides were determined by a fluorescence polarization immunoassay. A working definition of significant instability or incompatibility was defined as a greater than 10 percent loss of original antibiotic concentration. All single antibiotic solutions were stable throughout the observation periods. The clindamycin phosphate-amikacin sulfate combination was stable for 48 hours. While most frozen solutions were stable for 28 days, the tobramycin sulfate-clindamycin phosphate solution was only stable for 14 days, with the tobramycin sulfate concentration decreasing by 16.6 percent from its original concentration at 28 days.

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