scholarly journals Synthesis, Characterization and Spectroscopic Studies of Bis-(Meso-4- Methoxyphenyl)-Benziporphyrin and Its Pd-Metal Complex

2021 ◽  
Author(s):  
Endale Mulugeta ◽  
Hee Lee Change
Keyword(s):  
Metal Complex ◽  
Spectroscopic Studies

scholarly journals Co(II) Complex of Mefloquine Hydrochloride: Synthesis, Antimicrobial Potential, Antimalaria and Toxicological Activities

2012 ◽  
Vol 9 (4) ◽  
pp. 2245-2254 ◽  
Author(s):  
Adediji J. Femi ◽  
Obaleye J. Ayoola
Keyword(s):  
Metal Complex ◽  
Metal Ion ◽  
Analytical Data ◽  
Conductivity Measurement ◽  
Spectroscopic Studies ◽  
Plasmodium Yoelii ◽  
Tridentate Ligand ◽  
Rat Serum ◽  
Liver And Kidney

Transition metal complex of Co(II) with Mefloquine hydrochloride (antimalaria drug) was synthesized using template method. Chemical analysis including conductivity measurements and spectroscopic studies were used to propose the geometry and mode of binding of the ligand to metal ion. From analytical data, the stoichiometry of the complex has been found to be 1:1. Infrared spectral data also suggest that the ligand (mefloquine hydrochloride) behaves as a tridentate ligand with N:N:O donor sequence towards the metal ion. The complex generally showed octahedral coordinate geometry. Conductivity measurement of 10-2mol dm-3methanol solution of the complex indicated non-electrolytic nature of metal complex. It also revealed that the ligand anions were covalently bonded to the complex.In-vivoevaluation of antimicrobial studies of the metal complex showed greater activities when compared to the free mefloquine.The complex was screened against malarial parasites (Plasmodium yoelii nigeriensis): It was evident from the results obtained that Co(II) mefloquine has highest clearance of about 80% parasitaemia reduction compared to the free mefloquine. The ligand and metal complex were screened for their toxicological activities at the dose of 0.60 mg/Kg body weight twice daily for seven days on the alkaline phosphatase (ALP), alanine aminotranferase (ALT), and aspartate aminotransferase (AST) activities of rat serum, liver and kidney. Overall, it was revealed that both mefloquine and its metal complex do not showed toxicity particularly on the liver and kidney.

scholarly journals Synthesis, Characterization, and Spectroscopic Studies of Bis-(meso-4-methoxyphenyl)-Benziporphyrin and Its Pd-Metal Complex

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Endale Mulugeta ◽  
Chang-Hee Lee
Keyword(s):  
Metal Complex ◽  
Diethyl Ether ◽  
Trifluoroacetic Acid ◽  
Spectroscopic Studies ◽  
Free Base ◽  
Efficient Synthesis ◽  
Acetate Salt ◽  
Synthetic Routes

Benziporphyrin systems are widely explored, yet alternative improved synthetic routes towards these systems are needed. Here, a fairly and efficient synthesis of the free base and its metal complex is well designed. Dimethoxybenzene dicarbinol intermediate was prepared in excellent yields by reacting 4-methoxyphenylmagnesium bromide with isophthaladehyde in diethyl ether. Reaction with equivalent pyrrole and pentafluorobenzaldehyde in the presence of trifluoroacetic acid (TFA), followed by oxidation with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), provided good yields of bis-(meso-4-methoxyphenyl)-benziporphyrin. Metalation of the free base was performed using palladium(II) acetate salt in acetonitrile. All intermediates and the final products are fully characterized using NMR, HMRS, and UV-Vis spectroscopies and briefly discussed.

Spectroscopic studies of Pd (II) complexes with cysteine and its di- and tripeptides

1987 ◽  
Vol 84 ◽  
pp. 443-448 ◽  
Author(s):  
Teresa Kowalik ◽  
Brigitte Decock-Le Reverend ◽  
Claude Loucheux ◽  
Damien Ficheux ◽  
Henryk Kozlowski
Keyword(s):  
Spectroscopic Studies

MÖSSBAUER SPECTROSCOPIC STUDIES OF DIMENSIONALITY AND SPIN REDUCTION EFFECTS IN THE ANTIFERROMAGNETIC SYSTEMS : (AF)n-FeF3

1980 ◽  
Vol 41 (C1) ◽  
pp. C1-187-C1-188 ◽  
Author(s):  
G. P. Gupta ◽  
J. A. Baines ◽  
D. M. Cooper ◽  
D. P.E. Dickson ◽  
C. E. Johnson
Keyword(s):  
Spectroscopic Studies
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