Cross-Sectional and Longitudinal Comparisons of Biomarkers and Cognition Among Asymptomatic Middle-Aged Individuals with a Parental History of Either Autosomal Dominant or Late Onset Alzheimer Disease

2021 ◽  
Author(s):  
Chengjie Xiong ◽  
Lena McCue ◽  
Virginia Buckles ◽  
Elizabeth Grant ◽  
Folasade Agboola ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Autosomal Dominant ◽  
Late Onset ◽  
Middle Aged ◽  
Cross Sectional ◽  
Parental History ◽  
History Of

scholarly journals Association of education with Aβ burden in preclinical familial and sporadic Alzheimer disease

Neurology ◽  
2020 ◽  
Vol 95 (11) ◽  
pp. e1554-e1564
Author(s):  
Julie Gonneaud ◽  
Christophe Bedetti ◽  
Alexa Pichet Binette ◽  
Tammie L.S. Benzinger ◽  
John C. Morris ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Autosomal Dominant ◽  
Structural Mri ◽  
Cross Sectional ◽  
Parental History ◽  
Level Of Education ◽  
Mutation Carriers ◽  
History Of ◽  
Asymptomatic Individuals ◽  
Sporadic Alzheimer Disease

ObjectiveTo determine whether years of education and the ε4 risk allele at APOE influence β-amyloid (Aβ) pathology similarly in asymptomatic individuals with a family history of sporadic Alzheimer disease (AD) and presymptomatic autosomal dominant AD mutation carriers.MethodsWe analyzed cross-sectional data from 106 asymptomatic individuals with a parental history of sporadic AD (PREVENT-AD cohort; age 67.28 ± 4.72 years) and 117 presymptomatic autosomal dominant AD mutation carriers (DIAN cohort; age 35.04 ± 9.43 years). All participants underwent structural MRI and Aβ-PET imaging. In each cohort we investigated the influence of years of education, APOE ε4 status, and their interaction on Aβ-PET.ResultsAsymptomatic individuals with a parental history of sporadic AD showed increased Aβ burden associated with APOE ε4 carriage and lower level of education, but no interaction between these. Presymptomatic mutation carriers of autosomal dominant AD showed no relation between APOE ε4 and Aβ burden, but increasing level of education was associated with reduced Aβ burden. The association between educational attainment and Aβ burden was similar in the 2 cohorts.ConclusionsWhile the APOE ε4 allele confers increased tendency toward Aβ accumulation in sporadic AD only, protective environmental factors, like increased education, may promote brain resistance against Aβ pathology in both sporadic and autosomal dominant AD.

scholarly journals Vascular Factors and Markers of Inflammation in Offspring With a Parental History of Late-Onset Alzheimer Disease

2009 ◽  
Vol 66 (11) ◽  
pp. 1263 ◽  
Author(s):  
Eric van Exel ◽  
Piet Eikelenboom ◽  
Hannie Comijs ◽  
Marijke Frölich ◽  
Johannes H. Smit ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Late Onset ◽  
Parental History ◽  
Markers Of Inflammation ◽  
History Of

scholarly journals The Epidemiological Characteristics of Late-Onset Hypogonadism in Chinese Middle-Aged and Elderly Men: Two Cross-Sectional Studies in the Same Community

2020 ◽  
Vol 14 (6) ◽  
pp. 155798832097799
Author(s):  
Shan-Jie Zhou ◽  
Ming-Jia Zhao ◽  
Yi-Hong Yang ◽  
Di Guan ◽  
Zhi-Guang Li ◽  
...  
Keyword(s):  
Late Onset ◽  
Community Dwelling ◽  
Total Testosterone ◽  
Middle Aged ◽  
Cross Sectional ◽  
Cutoff Values ◽  
Significant Difference ◽  
Cross Sectional Studies ◽  
Late Onset Hypogonadism ◽  
Epidemiological Characteristics

The purpose of this study was to investigate the prevalence and epidemiological characteristics of late-onset hypogonadism (LOH) in middle-aged and elderly Chinese men. Two cross-sectional studies were conducted at 5-year intervals in community-dwelling men living in the same area. A total of 1472 (Study 1, S1) and 944 (Study 2, S2) men aged 40–69 years old were recruited as subjects. Subjects were evaluated through combining serum reproductive hormone levels with the Androgen Deficiency in Aging Males (ADAM) questionnaire and the Aging Males’ Symptoms (AMS) scale. A significant difference was found in mean testosterone deficiency (TD) prevalence between S1 and S2, using either serum total testosterone (TT; 14.02% vs. 6.36%) or serum calculated free testosterone (cFT; 43.69% vs. 16.53%) cutoff values. According to the S1 or S2 data, the mean prevalence of LOH was 37.85%/15.47% in the positive ADAM test and 15.42%/9.43% in the positive AMS test ( p < .01). According to classifications of TD based on gonadal status, the prevalence of secondary TD (27.34%) was higher than the primary (16.36%) and compensated (15.42%) TD in S1 ( p < .01). However, there were significant differences among the prevalence of primary (6.89%), secondary (9.64%), and compensated (27.65%) TD in S2 ( p < .05). Different types of testosterone levels, TD cutoff values, and questionnaires influenced the prevalence of TD and LOH. The serum FT cutoff value was an optimal threshold for evaluating and diagnosing TD and LOH, whose prevalence increased gradually with male aging.

Different rates of cognitive decline in autosomal dominant and late‐onset Alzheimer disease

2021 ◽  
Author(s):  
Virginia D. Buckles ◽  
Chengjie Xiong ◽  
Randall J. Bateman ◽  
Jason Hassenstab ◽  
Ricardo Allegri ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Cognitive Decline ◽  
Autosomal Dominant ◽  
Late Onset

P2-436: PIB-PET NEUROIMAGING CORRELATES WITH β-AMYLOIDOSIS IN BOTH LATE-ONSET AND AUTOSOMAL DOMINANT ALZHEIMER DISEASE

2006 ◽  
Vol 14 (7S_Part_16) ◽  
pp. P881-P881
Author(s):  
Namita Sinha ◽  
Aihong Zhou ◽  
Chengjie Xiong ◽  
John C. Morris ◽  
Randall J. Bateman ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Autosomal Dominant ◽  
Late Onset

scholarly journals Association of epileptiform abnormalities and seizures in Alzheimer disease

Neurology ◽  
2020 ◽  
Vol 95 (16) ◽  
pp. e2259-e2270 ◽  
Author(s):  
Alice D. Lam ◽  
Rani A. Sarkis ◽  
Kyle R. Pellerin ◽  
Jin Jing ◽  
Barbara A. Dworetzky ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Late Onset ◽  
Early Stage ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Cognitively Normal ◽  
Scalp Eeg ◽  
Epileptiform Discharges ◽  
Potential Biomarker ◽  
The Relationship

ObjectiveTo examine the relationship between scalp EEG biomarkers of hyperexcitability in Alzheimer disease (AD) and to determine how these electric biomarkers relate to the clinical expression of seizures in AD.MethodsIn this cross-sectional study, we performed 24-hour ambulatory scalp EEGs on 43 cognitively normal elderly healthy controls (HC), 41 participants with early-stage AD with no history or risk factors for epilepsy (AD-NoEp), and 15 participants with early-stage AD with late-onset epilepsy related to AD (AD-Ep). Two epileptologists blinded to diagnosis visually reviewed all EEGs and annotated all potential epileptiform abnormalities. A panel of 9 epileptologists blinded to diagnosis was then surveyed to generate a consensus interpretation of epileptiform abnormalities in each EEG.ResultsEpileptiform abnormalities were seen in 53% of AD-Ep, 22% of AD-NoEp, and 4.7% of HC. Specific features of epileptiform discharges, including high frequency, robust morphology, right temporal location, and occurrence during wakefulness and REM, were associated with clinical seizures in AD. Multiple EEG biomarkers concordantly demonstrated a pattern of left temporal lobe hyperexcitability in early stages of AD, whereas clinical seizures in AD were often associated with bitemporal hyperexcitability. Frequent small sharp spikes were specifically associated with epileptiform EEGs and thus identified as a potential biomarker of hyperexcitability in AD.ConclusionEpileptiform abnormalities are common in AD but not all equivalent. Specific features of epileptiform discharges are associated with clinical seizures in AD. Given the difficulty recognizing clinical seizures in AD, these EEG features could provide guidance on which patients with AD are at high risk for clinical seizures.

scholarly journals Functional Connectivity in Autosomal Dominant and Late-Onset Alzheimer Disease

2014 ◽  
Vol 71 (9) ◽  
pp. 1111 ◽  
Author(s):  
Jewell B. Thomas ◽  
Matthew R. Brier ◽  
Randall J. Bateman ◽  
Abraham Z. Snyder ◽  
Tammie L. Benzinger ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Alzheimer Disease ◽  
Autosomal Dominant ◽  
Late Onset

scholarly journals Risk factors of coronary heart disease in children and young adults with parental history of premature coronary heart disease

2016 ◽  
Vol 43 (2) ◽  
pp. 51
Author(s):  
Murti Andriastuti ◽  
Sudigdo Sastroasmoro ◽  
Agus Firmansyah
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Young Adults ◽  
Heart Disease ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Parental History ◽  
Passive Smoker ◽  
History Of ◽  
Children And Young Adults

Background Morbidity and mortality of coronary heart disease(CHD) are recently increasing. This is related to changes in lifestyle,such as lack of activity and high consumption of fatty diet. Themain cause of CHD is atherosclerosis. The development of ath-erosclerosis takes a long time, is asymptomatic, and might beginin childhood. The important risk factors that have roles in increas-ing the likelihood of atherosclerosis are family history of prematureCHD, hypertension, hyperlipidemia, obesity, smoking and irregu-lar activity.Objective The aim of this study was to find out the prevalence ofCHD risk factors in children and young adults who had parentalhistory of premature CHD.Methods This was a descriptive cross sectional study conductedon offspring of premature CHD patients who were admitted in theintensive cardiology care unit (ICCU) of Cipto MangunkusumoHospital between January 1999 to December 2001 and of prema-ture CHD patients who visited the Cardiology Clinic of the Depart-ment of Internal Medicine, Cipto Mangunkusumo Hospital duringMarch and April 2002. Subjects were aged 12 to 25 year-old.Results Among the subjects, 40% had hyperlipidemia, 8% hadhypertension, 11% were obese, 21% were active smokers, 41%were passive smokers, and 73% had irregular activity. Ninety-sevenpercents subjects had more than 1 risk factors.Conclusions The prevalence of hyperlipidemia, hypertension,obesity, passive smoker, active smoker and irregular activity inchildren and young adults with parental history of premature CHDin this study were higher than those in the normal population.Most had more than 1 risk factor, increasing the likelihood of CHD.A screening test should be performed on children with parentalhistory of premature CHD so that early preventive measures mightbe done to minimize the risk factors

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