The Diagonal Band of Broca Regulates Olfactory-Mediated Behaviors by Modulating Odor-Evoked Responses Within the Olfactory Bulb

2021 ◽  
Author(s):  
Monika Müller ◽  
Inna Schwarz ◽  
Irina Pavlova ◽  
Jens Schweihoff ◽  
Fabrizio Musacchio ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Evoked Responses ◽  
Diagonal Band ◽  
Diagonal Band Of Broca

scholarly journals The diagonal band of broca continually regulates olfactory-mediated behaviors by modulating odor-evoked responses within the olfactory bulb

2020 ◽  
Author(s):  
Inna Schwarz ◽  
Monika Müller ◽  
Irina Pavlova ◽  
Jens Schweihoff ◽  
Fabrizio Musacchio ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Basal Forebrain ◽  
Behavioral Responses ◽  
Brain Regions ◽  
Evoked Responses ◽  
Response Modulation ◽  
Top Down ◽  
Diagonal Band ◽  
Diagonal Band Of Broca ◽  
Interneuron Activity

AbstractSensory perception is modulated in a top-down fashion by higher brain regions to regulate the strength of its own input resulting in the adaptation of behavioral responses. In olfactory perception, the horizontal diagonal band of broca (HDB), embedded in the basal forebrain modulates olfactory information processing by recruiting olfactory bulb (OB) interneuron activity to shape excitatory OB output. Currently, little is known about how specific HDB to OB top down signaling affects complex olfactory-mediated behaviors. Here we show that the olfactory bulb is strongly and differentially innervated by HDB projections. HDB-silencing via tetanus toxin lead to reduced odor-evoked Ca2+-responses in glomeruli of the main OB, underscoring the HDB’s role in odor response modulation. Furthermore, selective, light-mediated silencing of only HDB to OB afferents completely prevented olfactory-mediated habituation and discrimination behaviors. Notably, also social habituation and discrimination behaviors were affected. Here we provide evidence for a novel tri-synaptic paraventricular nucleus (PVN)-HDB-OB axis responsible for modulating these types of behavior. Thus, HDB to OB projections constitute a central top-down pathway for olfactory-mediated habituation and discrimination.

scholarly journals A lateral hypothalamus to basal forebrain neurocircuit promotes feeding by suppressing responses to anxiogenic environmental cues

2019 ◽  
Vol 5 (3) ◽  
pp. eaav1640 ◽  
Author(s):  
Ryan M. Cassidy ◽  
Yungang Lu ◽  
Madhavi Jere ◽  
Jin-Bin Tian ◽  
Yuanzhong Xu ◽  
...  
Keyword(s):  
Lateral Hypothalamus ◽  
Basal Forebrain ◽  
Gabaergic Neurons ◽  
Inhibitory Input ◽  
Environmental Cues ◽  
Diagonal Band ◽  
Diagonal Band Of Broca ◽  
External Signals

Animals must consider competing information before deciding to eat: internal signals indicating the desirability of food and external signals indicating the risk involved in eating within a particular environment. The behaviors driven by the former are manifestations of hunger, and the latter, anxiety. The connection between pathologic anxiety and reduced eating in conditions like typical depression and anorexia is well known. Conversely, anti-anxiety drugs such as benzodiazepines increase appetite. Here, we show that GABAergic neurons in the diagonal band of Broca (DBBGABA) are responsive to indications of risk and receive monosynaptic inhibitory input from lateral hypothalamus GABAergic neurons (LHGABA). Activation of this circuit reduces anxiety and causes indiscriminate feeding. We also found that diazepam rapidly reduces DBBGABA activity while inducing indiscriminate feeding. Our study reveals that the LHGABA→DBBGABA neurocircuit overrides anxiogenic environmental cues to allow feeding and that this pathway may underlie the link between eating and anxiety-related disorders.

Volumetric analysis of the diagonal band of Broca in patients with schizophrenia and affective disorders: A post-mortem study

2015 ◽  
Vol 29 (4) ◽  
pp. 466-472 ◽  
Author(s):  
Ralf Brisch ◽  
Hans-Gert Bernstein ◽  
Henrik Dobrowolny ◽  
Marta Krzyżanowska ◽  
Zbigniew Jankowski ◽  
...  
Keyword(s):  
Affective Disorders ◽  
Volumetric Analysis ◽  
Post Mortem ◽  
Diagonal Band ◽  
Diagonal Band Of Broca

scholarly journals Co-activation of nAChR and mGluR induces γ oscillation in rat medial septum diagonal band of Broca slices

2014 ◽  
Vol 35 (2) ◽  
pp. 175-184
Author(s):  
Ya-li Wang ◽  
Jian-gang Wang ◽  
Gao-xiang Ou-yang ◽  
Xiao-li Li ◽  
Zaineb Henderson ◽  
...  
Keyword(s):  
Medial Septum ◽  
Diagonal Band ◽  
Co Activation ◽  
Diagonal Band Of Broca
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