Prognostic Significance of Modified Advanced Lung Cancer Inflammation Index in Patients with Renal Cell Carcinoma Undergoing Laparoscopic Nephrectomy: A Multi-Institutional, Propensity Score Matching Cohort Study

2021 ◽  
Author(s):  
Weipu Mao ◽  
Keyi Wang ◽  
Zonglin Wu ◽  
Jinliang Ni ◽  
Houliang Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Renal Cell Carcinoma ◽  
Cohort Study ◽  
Propensity Score ◽  
Cell Carcinoma ◽  
Propensity Score Matching ◽  
Renal Cell ◽  
Prognostic Significance ◽  
Advanced Lung Cancer ◽  
Cancer Inflammation

scholarly journals Can incomplete metastasectomy impact renal cell carcinoma outcomes? A propensity score matching analysis from a prospective multicenter collaboration

2021 ◽  
Vol 2 (2) ◽  
pp. 82-95
Author(s):  
Alice Dragomir ◽  
Charles Hesswani ◽  
Gautier Marcq ◽  
Alan I. So ◽  
Christian Kollmannsberger ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Propensity Score ◽  
Cell Carcinoma ◽  
Propensity Score Matching ◽  
Systemic Therapy ◽  
Renal Cell ◽  
Cancer Information ◽  
Incomplete Resection ◽  
The Impact

Objective: To evaluate the role of incomplete metastasectomy (IM) for patients with metastatic renal cell carcinoma (mRCC) on overall survival (OS) and time to introduction of first-line systemic therapy. Methodology: Patients diagnosed with mRCC between Jan 2011 and Apr 2019 in 16 centers were selected from the Canadian Kidney Cancer information system database. We included mRCC patients who had prior nephrectomy and had received an IM (resection of at least 1 metastasis) or no metastasectomy (NM). A propensity score matching was performed to minimize selection bias. Cox proportional hazards analysis was used to assess the impact of the metastasectomy while adjusting for potential confounders. OS was assessed by Kaplan-Meier analysis. Results: A total of 138 patients with mRCC underwent IM, while 1221 patients did not. On multivariate analysis, IM did not improve OS (hazard ratio [HR] 0.96, 95% CI 0.63 to 1.45, P = 0.836) However, subgroup analyses revealed IM improved OS compared with NM when lungs were the only site involved (median time to OS not reached versus 66 months, respectively; P = 0.014). Additionally, lung metastasectomy delayed the systemic therapy compared with NM (median 41 and 13 months, respectively, P = 0.014). IM of endocrine organs (thyroid, pancreas, adrenals) or bone metastases did not impact OS. Conclusion: The role of IM for mRCC is limited. Incomplete resection of lung metastases was associated with improved OS and delayed time to introduction of systemic therapy when lungs were the sole location of metastatic disease. Despite case-matching, unknown unadjusted confounders may explain the relationship between IM and survival in this analysis.

scholarly journals The role of cytoreductive nephrectomy in renal cell carcinoma patients with liver metastasis

2020 ◽  
Author(s):  
Boda Guo ◽  
Shengjing Liu ◽  
Miao Wang ◽  
Huimin Hou ◽  
Ming Liu
Keyword(s):  
Renal Cell Carcinoma ◽  
Overall Survival ◽  
Liver Metastasis ◽  
Propensity Score ◽  
Cell Carcinoma ◽  
Propensity Score Matching ◽  
Renal Cell ◽  
Cox Regression ◽  
Cytoreductive Nephrectomy ◽  
Dismal Prognosis

It is widely accepted that renal cell carcinoma with liver metastasis carries a dismal prognosis. We aimed to explore the value of cytoreductive nephrectomy among these patients. Patients were extracted from the SEER database between 2010 and 2017. The univariate and multivariate Cox proportional hazards models were conducted to select the prognostic predictors of survival. Patients were divided into nephrectomy and non-nephrectomy groups. Propensity score-matching analyses were applied to reduce the above factors’ differences between the groups. Overall survival was compared by Kaplan-Meier (K-M) analyses. Data from 683 patients was extracted from the database. The univariate Cox regression and multivariate Cox regression revealed that factors including age, histologic type, T and N stages, lung metastasis, brain metastasis, and nephrectomy were significant predictors of survival in the patients. After the propensity score-matching analyses, we found that nephrectomy prolonged overall survival. Nephrectomy can prolong overall survival in eligible renal cell carcinoma patients with liver metastasis.

Sign in / Sign up

Export Citation Format

Share Document