A Pan-Cancer Analysis of the Oncogenic Role of G Protein-Coupled Bile Acid Receptor 1(GPBAR1) in Human Tumors

2021 ◽  
Author(s):  
Zhiyuan Guan ◽  
Xiao Jin ◽  
Shengfu Liu ◽  
Zhong Wu ◽  
Ruijun Cong ◽  
...  
Keyword(s):  
Bile Acid ◽  
G Protein ◽  
Human Tumors ◽  
Acid Receptor ◽  
Bile Acid Receptor ◽  
G Protein Coupled ◽  
Pan Cancer

scholarly journals Targeted disruption of G protein-coupled bile acid receptor 1 (Gpbar1/M-Bar) in mice

2006 ◽  
Vol 191 (1) ◽  
pp. 197-205 ◽  
Author(s):  
Takaharu Maruyama ◽  
Kenichi Tanaka ◽  
Jun Suzuki ◽  
Hiroyuki Miyoshi ◽  
Naomoto Harada ◽  
...  
Keyword(s):  
Bile Acid ◽  
G Protein ◽  
Physiological Role ◽  
Wild Type ◽  
Fat Accumulation ◽  
Acid Receptor ◽  
Bile Acid Receptor ◽  
The Impact ◽  
G Protein Coupled

G protein-coupled bile acid receptor 1 (Gpbar1/M-Bar) is a novel G protein-coupled receptor for bile acid. Tissue distribution and cell-type specificity of Gpbar1 mRNA suggest a potential role for the receptor in the endocrine system; however, the precise physiological role of Gpbar1 still remains to be elucidated. To investigate the role of Gpbar1 in vivo, the Gpbar1 gene was disrupted in mice. In homozygous mice, total bile acid pool size was significantly decreased by 21–25% compared with that of the wild-type mice, suggesting that Gpbar1 contributes to bile acid homeostasis. In order to assess the impact of Gpbar1 deficiency in bile acid homeostasis more precisely, Gpbar1 homozygous mice were fed a high-fat diet for 2 months. As a result, female Gpbar1 homozygous mice showed significant fat accumulation with body weight gain compared with that of the wild-type mice. These findings were also observed in heterozygous mice to the same extent. Although the precise mechanism for fat accumulation in female Gpbar1 homozygous mice remains to be addressed, these data indicate that Gpbar1 is a potential new player in energy homeostasis. Thus, Gpbar1-deficient mice are useful in elucidating new physiological roles for Gpbar1.

scholarly journals The G protein coupled bile acid receptor TGR5 (Gpbar1) modulates endothelin-1 signaling in liver

2020 ◽  
Author(s):  
C Klindt ◽  
M Reich ◽  
B Hellweg ◽  
J Stindt ◽  
J Rahnenführer ◽  
...  
Keyword(s):  
Bile Acid ◽  
G Protein ◽  
Acid Receptor ◽  
Endothelin 1 ◽  
Bile Acid Receptor ◽  
G Protein Coupled

scholarly journals Allspice and Clove As Source of Triterpene Acids Activating the G Protein-Coupled Bile Acid Receptor TGR5

2017 ◽  
Vol 8 ◽  
Author(s):  
Angela Ladurner ◽  
Martin Zehl ◽  
Ulrike Grienke ◽  
Christoph Hofstadler ◽  
Nadina Faur ◽  
...  
Keyword(s):  
Bile Acid ◽  
G Protein ◽  
Acid Receptor ◽  
Triterpene Acids ◽  
Bile Acid Receptor ◽  
G Protein Coupled

Design of Gut-Restricted Thiazolidine Agonists of G Protein-Coupled Bile Acid Receptor 1 (GPBAR1, TGR5)

2018 ◽  
Vol 61 (17) ◽  
pp. 7589-7613 ◽  
Author(s):  
Tao Chen ◽  
Nicholas William Reich ◽  
Noah Bell ◽  
Patricia D. Finn ◽  
David Rodriguez ◽  
...  
Keyword(s):  
Bile Acid ◽  
G Protein ◽  
Acid Receptor ◽  
Bile Acid Receptor ◽  
G Protein Coupled
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