Involvement of Body Temperature Increase and Sympathetic Nerve Activation in Exercise-Induced Microbiota Changes in Mice

2021 ◽  
Author(s):  
Hiroyuki Sasaki ◽  
Hiroki Miyakawa ◽  
Aya Watanabe ◽  
Konomi Tamura ◽  
Kazuto Shiga ◽  
...  
Keyword(s):  
Body Temperature ◽  
Sympathetic Nerve ◽  
Temperature Increase ◽  
Sympathetic Nerve Activation ◽  
Exercise Induced ◽  
Body Temperature Increase

Aspirin is an effective pretreatment for exercise in multiple sclerosis: A double-blind randomized controlled pilot trial

2017 ◽  
Vol 24 (11) ◽  
pp. 1511-1513 ◽  
Author(s):  
Victoria M Leavitt ◽  
Adam R Blanchard ◽  
Chu-Yueh Guo ◽  
Eva Gelernt ◽  
James F Sumowski ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Body Temperature ◽  
Temperature Increase ◽  
Pilot Trial ◽  
Time To Exhaustion ◽  
Heat Sensitivity ◽  
Double Blind ◽  
Ergometer Exercise ◽  
Exercise Induced ◽  
Body Temperature Increase

Exercise benefits multiple sclerosis (MS) patients, but exercise-induced overheating is a deterrent for many. We conducted a double-blind crossover-design placebo-controlled pilot of aspirin to increase time-to-exhaustion (TTE) and reduce exercise-induced body temperature increase. A total of 12 patients participated. At enrollment, 8 of 12 reported heat sensitivity during exercise. After 650 mg of aspirin or placebo, participants performed lower body cycle ergometer exercise test. TTE increased after aspirin compared to placebo: t(11) = 2.405, p = 0.035 (Cohen’s d = 1.45). Body temperature increase after exercise with acetylsalicylic acid (ASA) was reduced by 56% in heat-sensitive patients, although limited power precluded statistical significance. Aspirin may represent an effective pretreatment for exercise in MS.

Acceleration of Circadian Phase Delay by Body Temperature Increase During Nocturnal Exercise in Healthy Men

2006 ◽  
Vol 38 (Supplement) ◽  
pp. S358
Author(s):  
Sung Eun Ho ◽  
Jee Eun Son ◽  
Hyae Ran An ◽  
Youngnam Kang ◽  
Dae Taek Lee
Keyword(s):  
Body Temperature ◽  
Temperature Increase ◽  
Phase Delay ◽  
Healthy Men ◽  
Circadian Phase ◽  
Body Temperature Increase

Characterization of growth hormone release in response to external heating Comparison to exercise induced release

1984 ◽  
Vol 107 (3) ◽  
pp. 295-301 ◽  
Author(s):  
Stig Engkjær Christensen ◽  
Otto Lunde Jørgensen ◽  
Niels Møller ◽  
Hans Ørskov
Keyword(s):  
Growth Hormone ◽  
Body Temperature ◽  
Temperature Increase ◽  
Clinical Test ◽  
Fasting State ◽  
Gh Secretion ◽  
External Heating ◽  
Normal Males ◽  
Exercise Induced ◽  
Plasma Gh

Abstract. The effects of increases in body temperature on growth hormone (GH)-release were studied in 10 young normal males in the fasting state as well as postprandially. The temperature increase of one degree centigrade was attained by external heating using thermostatically controlled water blankets covered by heat-reflecting aluminium foil. The increase in plasma GH after heating was partially suppressed in the non-fasting state reaching a mean of 7.9 ± 3.5 (sem), ng/ml, range 1.0–36 ng/ml. In contrast all subjects exhibited higher increases, mean 18.3 ± 4.0 ng/ml, range 7–44 ng/ml, in response to heating when fasting. The results were compared in the same subjects to the plasma GH-responses obtained during exercise (450 kpm/min for 40 min) inducing a similar increase in body temperature of about one degree centrigrade. Nevertheless the response in plasma GH (8.4 ± 3.3 ng/ml, range 0.4–34 ng/ml) was smaller than obtained by the heat test despite a rate of temperature increase on exercise which was about twice as high. Furthermore, the same exercise performed in a cold room under circumstances which precluded any major rises in core temperature resulted in complete inhibition of GH-release. The results indicate that exercise per se does not stimulate GH-secretion, indeed it may inhibit the response expected to be evoked by the exercise-induced rise in temperature. Evidence is also presented that it is core and not cutaneous temperature which modulated GH release. The procedure used for inducing the rise in temperature and plasma GH may be used as a simple, acceptable and safe clinical test for GH-insufficiency.

Studies on the adaptability of three breeds of sheep to a tropical environment modified by altitude I. The annual fluctuation in body temperature and body temperature increase between 6.30 a.m. and 12.30 p.m.

1960 ◽  
Vol 55 (3) ◽  
pp. 287-294 ◽  
Author(s):  
R. B. Symington
Keyword(s):  
Body Temperature ◽  
Temperature Increase ◽  
Skin Pigmentation ◽  
Ambient Air ◽  
Early Morning ◽  
Coat Colour ◽  
Body Temperatures ◽  
Annual Fluctuation ◽  
Southern Rhodesia ◽  
Body Temperature Increase

Early morning and midday body temperatures of rams and ewes of three breeds of sheep were measured once weekly for a period of 10 months in Northern Rhodesia and 12 months in Southern Rhodesia.1. In all breeds seasonal fluctuations in body temperature were due to concurrent fluctuations in ambient air temperature.2. Mean annual body temperatures were: Merino 102·2° F.; Persian 101·7° F. and Native 101·7° F. Wool and hair breeds differed considerably in their early morning temperatures and in their body temperature increases from 6.30 a.m. to 12.30 p.m. Mean annual values for these measurements were Merino 101·73 and 1·92° F.; Persian 100·81 and 1·83° F.; Native 100·73 and 1–92° F. At all times Merinos showed markedly greater uniformity of body temperature than either hair breed. There was no evidence to show that the thermoregulatory mechanisms of these animals had been stressed unduly.3. Sex had no consistent effect on body temperature or on rise in body temperature.In general, lactating ewes showed a significantly higher initial body temperature than either empty or pregnant ewes, but the respective heat tolerances as measured by body temperature increase did not differ appreciably. Body temperature differed little in empty and pregnant ewes.4. Although the youngest group of ewes in each breed showed the highest early morning temperature, there was no evidence that heat tolerance was less in young than in old animals.5. Black-coated Native ewes had higher initial body temperatures and a smaller body temperature increase during the summer months in Southern Rhodesia than brown or broken-coloured Native ewes. These effects were due to differences in coat density rather than to differences in coat colour or skin pigmentation.6. In all breeds the magnitude of the diurnal and annual variation in body temperature was different in Northern and Southern Rhodesia. Differences were largely of climatic origin but low plane of nutrition in Southern Rhodesia possibly reduced critical body temperature and impaired thermoregulatory ability.

scholarly journals Afferent thermosensory function in relapsing-remitting multiple sclerosis following exercise-induced increases in body temperature

2017 ◽  
Vol 102 (8) ◽  
pp. 887-893 ◽  
Author(s):  
Davide Filingeri ◽  
Georgia Chaseling ◽  
Phu Hoang ◽  
Michael Barnett ◽  
Scott L. Davis ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Body Temperature ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Exercise Induced ◽  
Relapsing Remitting Multiple Sclerosis

scholarly journals The Impact of Central and Peripheral Cyclooxygenase Enzyme Inhibition on Exercise-Induced Elevations in Core Body Temperature

2017 ◽  
Vol 12 (5) ◽  
pp. 662-667 ◽  
Author(s):  
Matthijs T.W. Veltmeijer ◽  
Dineke Veeneman ◽  
Coen C.C.W. Bongers ◽  
Mihai G. Netea ◽  
Jos W. van der Meer ◽  
...  
Keyword(s):  
Heart Rate ◽  
Body Temperature ◽  
Skin Temperature ◽  
Core Body Temperature ◽  
Exercise Tests ◽  
Hypothalamic Temperature ◽  
Set Point ◽  
Exercise Induced ◽  
Core Body ◽  
The Impact

Purpose:Exercise increases core body temperature (TC) due to metabolic heat production. However, the exercise-induced release of inflammatory cytokines including interleukin-6 (IL-6) may also contribute to the rise in TC by increasing the hypothalamic temperature set point. This study investigated whether the exercise-induced increase in TC is partly caused by an altered hypothalamic temperature set point.Methods:Fifteen healthy, active men age 36 ± 14 y were recruited. Subjects performed submaximal treadmill exercise in 3 randomized test conditions: (1) 400 mg ibuprofen and 1000 mg acetaminophen (IBU/APAP), (2) 1000 mg acetaminophen (APAP), and (3) a control condition (CTRL). Acetaminophen and ibuprofen were used to block the effect of IL-6 at a central and peripheral level, respectively. TC, skin temperature, and heart rate were measured continuously during the submaximal exercise tests.Results:Baseline values of TC, skin temperature, and heart rate did not differ across conditions. Serum IL-6 concentrations increased in all 3 conditions. A significantly lower peak TC was observed in IBU/APAP (38.8°C ± 0.4°C) vs CTRL (39.2°C ± 0.5°C, P = .02) but not in APAP (38.9°C ± 0.4°C) vs CTRL. Similarly, a lower ΔTC was observed in IBU/APAP (1.7°C ± 0.3°C) vs CTRL (2.0°C ± 0.5°C, P < .02) but not in APAP (1.7°C ± 0.5°C) vs CTRL. No differences were observed in skin temperature and heart-rate responses across conditions.Conclusions:The combined administration of acetaminophen and ibuprofen resulted in an attenuated increase in TC during exercise compared with a CTRL. This observation suggests that a prostaglandin-E2-induced elevated hypothalamic temperature set point may contribute to the exercise-induced rise in TC.

scholarly journals Sympathoadrenal influence on glucose, FFA, and insulin levels in exercising rats

1989 ◽  
Vol 256 (1) ◽  
pp. R161-R168 ◽  
Author(s):  
A. J. Scheurink ◽  
A. B. Steffens ◽  
H. Bouritius ◽  
G. H. Dreteler ◽  
R. Bruntink ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Blood Glucose ◽  
Sympathetic Nerve ◽  
Intravenous Infusion ◽  
Blood Samples ◽  
Liver And Pancreas ◽  
Adrenoceptor Agonists ◽  
Glucose Plasma ◽  
Exercise Induced

The effects of sympathoadrenal manipulations on the exercise-induced alterations in blood glucose, plasma free fatty acids (FFA), and insulin were investigated in intact and adrenodemedullated rats. Exercise consisted of strenuous swimming against a countercurrent for 15 min. Before, during, and after swimming, blood samples were taken through a permanent heart catheter. Adrenodemedullation (Adm) markedly reduced the exercise-induced increase in both glucose and FFA. This effect was counteracted by intravenous infusion of epinephrine (E, 20 ng/min). Intravenous infusion of 50 ng E/min into Adm rats caused an exaggerated increase in glucose. In two additional experiments 1) specific adrenoceptor agonists and antagonists were administered to exercising intact and Adm rats, and 2) E or norepinephrine (NE; 20 ng/min) was infused into intact resting rats. The results suggest that E from the adrenal medulla directly affects glucose and insulin but not FFA concentrations in the blood. NE released from peripheral sympathetic nerve endings probably acts in two different ways: as neurotransmitter on liver and pancreas and as a hormone on adipose tissue.

The effect of vasodilatation and sympathetic nerve activation on net water absorption in the cat's small intestine

1979 ◽  
Vol 106 (1) ◽  
pp. 61-68 ◽  
Author(s):  
INGEMAR BRUNSSON ◽  
STEFAN EKLUND ◽  
MATS JODAL ◽  
OVE LUNDGREN ◽  
HENRIK SJÖVALL
Keyword(s):  
Small Intestine ◽  
Water Absorption ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activation

Effects of central injection of l-carnosine on sympathetic nerve activity innervating brown adipose tissue and body temperature in rats

2007 ◽  
Vol 144 (1-3) ◽  
pp. 62-71 ◽  
Author(s):  
Mamoru Tanida ◽  
Hitoshi Gotoh ◽  
Hiroyuki Taniguchi ◽  
Hiroto Otani ◽  
Jiao Shen ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Body Temperature ◽  
Brown Adipose Tissue ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Nerve Activity ◽  
Brown Adipose
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