scholarly journals Scaling Up to Meet New Challenges of Brain and Behaviour: Deep Brain Electrophysiology in Freely Moving Sheep

2021 ◽  
Author(s):  
Nikolas Perentos ◽  
Marino Krstulovic ◽  
A. Jennifer Morton
Keyword(s):  
Scaling Up ◽  
Freely Moving ◽  
New Challenges ◽  
Deep Brain ◽  
Brain Electrophysiology

scholarly journals Deep brain electrophysiology in freely moving sheep

2022 ◽  
Author(s):  
Nikolas Perentos ◽  
Marino Krstulovic ◽  
A. Jennifer Morton
Keyword(s):  
Freely Moving ◽  
Deep Brain ◽  
Brain Electrophysiology

An implantable CMOS image sensor for monitoring deep brain activities of a freely moving mouse

2008 ◽  
Author(s):  
Jun Ohta ◽  
Asako Higuchi ◽  
Ayato Tagawa ◽  
Kiyotaka Sasagawa ◽  
Takashi Tokuda ◽  
...  
Keyword(s):  
Cmos Image Sensor ◽  
Image Sensor ◽  
Freely Moving ◽  
Deep Brain

scholarly journals Circuit-specific sonogenetic stimulation of the deep brain elicits distinct signaling and behaviors in freely moving mice

2021 ◽  
Author(s):  
Quanxiang Xian ◽  
Zhihai Qiu ◽  
Shashwati Kala ◽  
Kin Fung Wong ◽  
Suresh Murugappan ◽  
...  
Keyword(s):  
Low Frequency ◽  
Dorsal Striatum ◽  
Neural Pathways ◽  
Spatiotemporal Resolution ◽  
Trigger Activity ◽  
Freely Moving ◽  
Subcortical Regions ◽  
Ultrasonic Stimulation ◽  
Deep Brain ◽  
Stimulation Of

Sonogenetics uses heterologously-expressed proteins to sensitize neurons to ultrasound, enabling selective, non-invasive, and deep brain stimulation. However, its ability to modulate specific circuits or induce behavioral changes remains to be studied and characterized. Here, we demonstrate that sonogenetics enables efficient activation of well-defined neural circuits by transcranial low-intensity, low-frequency ultrasonic stimulation with high spatiotemporal resolution. Targeted neurons in subcortical regions were made to express a mechanosensitive ion channel (MscL-G22S). Ultrasound could trigger activity in MscL-expressing neurons in the dorsal striatum without increased activation in neighboring regions, and increase locomotion in freely-moving mice. Ultrasound stimulation of MscL-expressing neurons in the ventral tegmental area could activate the mesolimbic pathway to trigger dopamine release in the nucleus accumbens and modulate appetitive conditioning. In MscL-expressing cells, neuronal responses to ultrasound pulses were rapid, reversible and repeatable. Altogether, we show that sonogenetics can selectively manipulate targeted cells to activate defined neural pathways and affect behaviors.

scholarly journals Fully implanted adaptive deep brain stimulation in freely moving essential tremor patients

2020 ◽  
Vol 17 (5) ◽  
pp. 056026
Author(s):  
B I Ferleger ◽  
B Houston ◽  
M C Thompson ◽  
S S Cooper ◽  
K S Sonnet ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Essential Tremor ◽  
Brain Stimulation ◽  
Freely Moving ◽  
Deep Brain

scholarly journals In vivo photopharmacology enabled by multifunctional fibers

2020 ◽  
Author(s):  
James A. Frank ◽  
Marc-Joseph Antonini ◽  
Po-Han Chiang ◽  
Andres Canales ◽  
David B. Konrad ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Optical Switch ◽  
Brain Regions ◽  
Behavioral Experiments ◽  
Mesolimbic Pathway ◽  
Molecular Neuroscience ◽  
Freely Moving ◽  
Thermal Drawing ◽  
Deep Brain

ABSTRACTTo reversibly manipulate neural circuits with increased spatial and temporal control, photoswitchable ligands can add an optical switch to a target receptor or signaling cascade. This approach, termed photopharmacology, has been enabling to molecular neuroscience, however, its application to behavioral experiments has been impeded by a lack of integrated hardware capable of delivering both light and compounds to deep brain regions in moving subjects. Here, we devise a hybrid photochemical genetic approach to target neurons using a photoswitchable agonist of capsaicin receptor (TRPV1), red-AzCA-4. Using the thermal drawing process we created multifunctional fibers that can deliver viruses, photoswitchable ligands, and light to deep brain regions in awake, freely moving mice. We implanted our fibers into the ventral tegmental area (VTA), a midbrain hub of the mesolimbic pathway, and used them to deliver a transgene coding for TRPV1. This sensitized excitatory VTA neurons to red-AzCA-4, and allowed us to optically control conditioned place preference using a mammalian ion-channel, thus extending applications of photopharmacology to behavioral experiments. Applied to endogenous receptors, our approach may accelerate studies of molecular mechanisms underlying animal behavior.

scholarly journals Author response: Magnetothermal genetic deep brain stimulation of motor behaviors in awake, freely moving mice

2017 ◽  
Author(s):  
Rahul Munshi ◽  
Shahnaz M Qadri ◽  
Qian Zhang ◽  
Idoia Castellanos Rubio ◽  
Pablo del Pino ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Author Response ◽  
Motor Behaviors ◽  
Freely Moving ◽  
Deep Brain ◽  
Stimulation Of
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