Early Platelet Dynamics During Staphylococcus Aureus Bacteremia is Associated with Dysregulated Cytokine Response and Predictive of Microbial Persistence and Mortality

2021 ◽  
Author(s):  
Rachid Douglas-Louis ◽  
Brian V. Lee ◽  
Emi Minejima ◽  
Mimi Lou ◽  
Juliane Bubeck Wardenburg ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Cytokine Response ◽  
Platelet Dynamics

scholarly journals Cytokine response in patients with chronic infections caused by Staphylococcus aureus strains and diversification of their Agr system classes

2012 ◽  
Vol 31 (10) ◽  
pp. 2809-2815 ◽  
Author(s):  
A. Szkaradkiewicz ◽  
T. M. Karpiński ◽  
A. Zeidler ◽  
A. K. Szkaradkiewicz ◽  
H. Masiuk ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Cytokine Response ◽  
Chronic Infections

scholarly journals CCR-2 neutralization augments murine fresh BMC activation by Staphylococcus aureus via two distinct mechanisms: at the level of ROS production and cytokine response

2017 ◽  
Vol 23 (4) ◽  
pp. 345-372 ◽  
Author(s):  
Ajeya Nandi ◽  
Biswadev Bishayi
Keyword(s):  
Reactive Oxygen Species ◽  
Staphylococcus Aureus ◽  
Bone Marrow ◽  
P38 Mapk ◽  
Bone Marrow Cells ◽  
Cytokine Response ◽  
Ros Production ◽  
Oxygen Species ◽  
Murine Bone Marrow ◽  
Aureus Infection

CCR-2 signaling regulates recruitment of monocytes from the bone marrow into the bloodstream and then to sites of infection. We sought to determine whether CCL-2/CCR-2 signaling is involved in the killing of Staphylococcus aureus by murine bone marrow cells (BMCs). The intermittent link of reactive oxygen species (ROS)–NF-κB/p38–MAPK-mediated CCL-2 production in CCR-2 signaling prompted us to determine whether neutralization of CCR-2 augments the response of murine fresh BMCs (FBMCs) after S. aureus infection. It was observed that anti-CCR-2 Ab-treated FBMCs released fewer ROS on encountering S. aureus infection than CCR-2 non-neutralized FBMCs, also correlating with reduced killing of S. aureus in CCR-2 neutralized FBMCs. Staphylococcal catalase and SOD were also found to play a role in protecting S. aureus from the ROS-mediated killing of FBMC. S. aureus infection of CCR-2 intact FBMCs pre-treated with either NF-κB or p-38-MAPK blocker induced less CCL-2, suggesting that NF-κB or p-38-MAPK is required for CCL-2 production by FBMCs. Moreover, blocking of CCR-2 along with NF-κB or p-38-MAPK resulted in elevated CCL-2 production and reduced CCR-2 expression. Inhibition of CCR-2 impairs the response of murine BMCs to S. aureus infection by attenuation ROS production and modulating the cytokine response.

scholarly journals Cytokine response to staphylococcal exotoxins in Staphylococcus aureus septicemia

1998 ◽  
Vol 4 (7) ◽  
pp. 366-372 ◽  
Author(s):  
Bo Söderquist ◽  
Krysztof Kanclerski ◽  
Karl-Gössta Sundqvist ◽  
Patricia Colque-Navarro ◽  
Hans Holmberg ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Cytokine Response

scholarly journals Escherichia coli and Staphylococcus aureus Elicit Differential Innate Immune Responses following Intramammary Infection

2004 ◽  
Vol 11 (3) ◽  
pp. 463-472 ◽  
Author(s):  
Douglas D. Bannerman ◽  
Max J. Paape ◽  
Jai-Wei Lee ◽  
Xin Zhao ◽  
Jayne C. Hope ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Immune Responses ◽  
Clinical Mastitis ◽  
Cytokine Response ◽  
Innate Immune ◽  
Host Recognition ◽  
Innate Immune Responses ◽  
E Coli ◽  
Intramammary Infection

ABSTRACTStaphylococcus aureusandEscherichia coliare among the most prevalent species of gram-positive and gram-negative bacteria, respectively, that induce clinical mastitis. The innate immune system comprises the immediate host defense mechanisms to protect against infection and contributes to the initial detection of and proinflammatory response to infectious pathogens. The objective of the present study was to characterize the different innate immune responses to experimental intramammary infection withE. coliandS. aureusduring clinical mastitis. The cytokine response and changes in the levels of soluble CD14 (sCD14) and lipopolysaccharide-binding protein (LBP), two proteins that contribute to host recognition of bacterial cell wall products, were studied. Intramammary infection with eitherE. coliorS. aureuselicited systemic changes, including decreased milk output, a febrile response, and induction of the acute-phase synthesis of LBP. Infection with either bacterium resulted in increased levels of interleukin 1β (IL-1β), gamma interferon, IL-12, sCD14, and LBP in milk. High levels of the complement cleavage product C5a and the anti-inflammatory cytokine IL-10 were detected at several time points followingE. coliinfection, whereasS. aureusinfection elicited a slight but detectable increase in these mediators at a single time point. Increases in IL-8 and tumor necrosis factor alpha were observed only in quarters infected withE. coli. Together, these data demonstrate the variability of the host innate immune response toE. coliandS. aureusand suggest that the limited cytokine response toS. aureusmay contribute to the well-known ability of the bacterium to establish chronic intramammary infection.

Cytokine Response in Autovaccine-Treated Patients with Chronic Staphylococcus Aureus Infections

2013 ◽  
Vol 11 (1) ◽  
pp. 103-110 ◽  
Author(s):  
A. Szkaradkiewicz ◽  
T.M. Karpiński ◽  
O. Goślińska-Pawłowska ◽  
A.K. Szkaradkiewicz ◽  
S. Giedrys-Kalemba
Keyword(s):  
Staphylococcus Aureus ◽  
Cytokine Response

scholarly journals Heterozygous Toll-Like Receptor 2 Polymorphism Does Not Affect Lipoteichoic Acid-Induced Chemokine and Inflammatory Responses

2004 ◽  
Vol 72 (3) ◽  
pp. 1828-1831 ◽  
Author(s):  
Sonja von Aulock ◽  
Nicolas W. J. Schröder ◽  
Stephanie Traub ◽  
Katja Gueinzius ◽  
Eva Lorenz ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Inflammatory Response ◽  
Inflammatory Responses ◽  
Lipoteichoic Acid ◽  
Cytokine Response ◽  
Toll Like Receptor ◽  
Wild Type ◽  
Functional Allele ◽  
Polymorphic Gene ◽  
Toll Like Receptor 2

ABSTRACT While transfection of tlr2 conveyed responsiveness to lipoteichoic acid (LTA), the Arg753Gln polymorphic gene could not. LTA induced a stronger chemokine and anti-inflammatory response than lipopolysaccharides did. Blood from heterozygous polymorphic and wild-type donors reacted uniformly to LTA and Staphylococcus aureus. Thus, one functional allele for Toll-like receptor 2 suffices for full cytokine response.

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