Dual Response to IL-21 and IFN-Alpha Reveals Human B-Cell Precursors With Multiple Differentiation Potentials

2021 ◽  
Author(s):  
Marina Boudigou ◽  
Magalie Michée-Cospolite ◽  
Patrice Hémon ◽  
Alexis Grasseau ◽  
Christelle Le Dantec ◽  
...  
Keyword(s):  
B Cell ◽  
Ifn Alpha ◽  
Dual Response ◽  
Multiple Differentiation ◽  
B Cell Precursors ◽  
Human B Cell

scholarly journals Physical and Functional Interactions between Lyn and p34 Kinases in Irradiated Human B-cell Precursors

1996 ◽  
Vol 271 (11) ◽  
pp. 6389-6397 ◽  
Author(s):  
Fatih M. Uckun ◽  
Lisa Tuel-Ahlgren ◽  
Kevin G. Waddick ◽  
Xiao Jun ◽  
Jizhong Jin ◽  
...  
Keyword(s):  
B Cell ◽  
Functional Interactions ◽  
B Cell Precursors ◽  
Human B Cell

scholarly journals Activation-Induced Cytidine Deaminase Expression in Human B Cell Precursors Is Essential for Central B Cell Tolerance

Immunity ◽  
2015 ◽  
Vol 43 (5) ◽  
pp. 884-895 ◽  
Author(s):  
Tineke Cantaert ◽  
Jean-Nicolas Schickel ◽  
Jason M. Bannock ◽  
Yen-Shing Ng ◽  
Christopher Massad ◽  
...  
Keyword(s):  
B Cell ◽  
Cytidine Deaminase ◽  
Cell Tolerance ◽  
B Cell Tolerance ◽  
Activation Induced Cytidine Deaminase ◽  
B Cell Precursors ◽  
Human B Cell

Role of Hydroxyl Radicals in Radiation-Induced Activation of Lyn Tyrosine Kinase in Human B-Cell Precursors

1996 ◽  
Vol 22 (5-6) ◽  
pp. 421-430 ◽  
Author(s):  
Jun Xiao ◽  
John E. Biaglow ◽  
Hean-Joo Chae-Park ◽  
Jizhong Jin ◽  
Lisa Tuel-Ahlgren ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
B Cell ◽  
Hydroxyl Radicals ◽  
Radiation Induced ◽  
Lyn Tyrosine Kinase ◽  
B Cell Precursors ◽  
Human B Cell

scholarly journals Contact Between Human Bone Marrow Stromal Cells and B Lymphocytes Enhances Very Late Antigen-4/Vascular Cell Adhesion Molecule-1–Independent Tyrosine Phosphorylation of Focal Adhesion Kinase, Paxillin, and ERK2 in Stromal Cells

Blood ◽  
1997 ◽  
Vol 90 (4) ◽  
pp. 1626-1635 ◽  
Author(s):  
Lisa J. Jarvis ◽  
Jean E. Maguire ◽  
Tucker W. LeBien
Keyword(s):  
Bone Marrow ◽  
B Cell ◽  
Tyrosine Phosphorylation ◽  
Stromal Cells ◽  
Stromal Cell ◽  
Late Antigen ◽  
Normal Human ◽  
B Cell Precursors ◽  
Cell Adhesion Molecule 1 ◽  
Human B Cell

Contact with bone marrow stromal cells is crucial for the normal growth and development of B-cell precursors. We have previously shown that human bone marrow stromal cell tyrosine kinase activity can be activated by direct contact with B-lymphoid cells (J Immunol 155:2359, 1995). In the present study, we show that increased tyrosine phosphorylation of focal adhesion kinase, paxillin, and extracellular-related kinase 2 (or p42 MAP kinase) accounted for the major changes occurring in stromal cell tyrosine phosphorylation after 5 to 10 minutes of contact with the RAMOS B-lymphoma cell line. Although adhesion of B-cell precursors to stromal cells is primarily mediated by very late antigen-4 (VLA-4) and vascular cell adhesion molecule-1 (VCAM-1), VLA-4–deficient and adhesion-deficient RAMOS cells were equally capable of stimulating stromal cell tyrosine phosphorylation. Similar changes in the tyrosine phosphorylation pattern of stromal cells were induced by contact with normal human B-cell precursors and several other B-lineage cell lines. After 5 to 30 minutes of contact with stromal cells, no change in protein tyrosine phosphorylation was detected in RAMOS or normal human B-cell precursors removed from stromal cells. Pretreatment of stromal cells with cytochalasin D abrogated contact-mediated enhancement of stromal cell tyrosine phosphorylation, suggesting that an intact cytoskeleton was essential. These results suggest that B-cell contact activates stromal cell signaling cascades that regulate cytoskeletal organization and transcription, independent of the interaction mediated by VLA-4 and VCAM-1.

scholarly journals Decreased IL7Rα and TdT expression underlie the skewed immunoglobulin repertoire of human B-cell precursors from fetal origin

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Magdalena B. Rother ◽  
Kristin Jensen ◽  
Mirjam van der Burg ◽  
Fleur S. van de Bovenkamp ◽  
Roel Kroek ◽  
...  
Keyword(s):  
B Cell ◽  
Fetal Origin ◽  
Immunoglobulin Repertoire ◽  
B Cell Precursors ◽  
Human B Cell

Characteristic expression of Hck in human B-cell precursors

2000 ◽  
Vol 28 (3) ◽  
pp. 349 ◽  
Author(s):  
Tomoko Taguchi ◽  
Nobutaka Kiyokawa ◽  
Norihide Sato ◽  
Masahiro Saito ◽  
Junichiro Fujimoto
Keyword(s):  
B Cell ◽  
B Cell Precursors ◽  
Human B Cell
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