Therapeutic Potential of Exosomal circRNA Derived from Synovial Mesenchymal Cell via Targeting circEDIL3/miR-485-3p/PIAS3/STAT3/VEGF Functional Module in Rheumatoid Arthritis

2021 ◽  
Author(s):  
Juan Zhang ◽  
Yue Zhang ◽  
Yeye Ma ◽  
Lili Luo ◽  
Maolin Chu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Therapeutic Potential ◽  
Functional Module ◽  
Mesenchymal Cell

Efficacy of Berberine in Treatment of Rheumatoid Arthritis: from Multiple Targets to Therapeutic Potential

2021 ◽  
pp. 105667
Author(s):  
Dan-na Huang ◽  
Fang-fang Wu ◽  
Ai-hua Zhang ◽  
Hui Sun ◽  
Xi-jun Wang
Keyword(s):  
Rheumatoid Arthritis ◽  
Therapeutic Potential ◽  
Multiple Targets

scholarly journals Suppression of T cell responses by chondromodulin I, a cartilage-derived angiogenesis inhibitory factor: Therapeutic potential in rheumatoid arthritis

2004 ◽  
Vol 50 (3) ◽  
pp. 828-839 ◽  
Author(s):  
Keigo Setoguchi ◽  
Yoshikata Misaki ◽  
Kimito Kawahata ◽  
Kota Shimada ◽  
Takuo Juji ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
T Cell ◽  
Therapeutic Potential ◽  
T Cell Responses ◽  
Inhibitory Factor ◽  
Cell Responses

scholarly journals The therapeutic potential of plant flavonoids on rheumatoid arthritis

2017 ◽  
Vol 57 (17) ◽  
pp. 3601-3613 ◽  
Author(s):  
Samuel D. Hughes ◽  
Natkunam Ketheesan ◽  
Nagaraja Haleagrahara
Keyword(s):  
Rheumatoid Arthritis ◽  
Therapeutic Potential

Quercetin: A Potential Candidate For The Treatment Of Arthritis

2021 ◽  
Vol 21 ◽  
Author(s):  
Ahsas Goyal ◽  
Neetu Agrawal
Keyword(s):  
Rheumatoid Arthritis ◽  
Medicinal Plants ◽  
Therapeutic Potential ◽  
Gouty Arthritis ◽  
Potential Candidate ◽  
Protective Effects ◽  
Preclinical Models ◽  
Healthy Life ◽  
Health Promoting ◽  
Dietary Component

: Diet plays a significant role in ensuring healthy life and the bioactive compounds present in food and medicinal plants may be developed as drugs that combat various illnesses. A bioactive flavanoid, quercetin which is a dietary component possesses numerous health-promoting effects. In preclinical models of rheumatoid arthritis, gouty arthritis and osteoarthritis, quercetin has shown significant joint protective effects. Taking into account the significance of this compound, the present review discusses its anti-arthritic properties, demonstrating its mechanism of action for the treatment of arthritis with its therapeutic potential.

Anti-proliferative and anti-inflammatory activities of belinostat: Therapeutic potential for rheumatoid arthritis?

Bone ◽  
2008 ◽  
Vol 43 ◽  
pp. S99
Author(s):  
Haishu Lin ◽  
Qiuyi Choo ◽  
Jia Yang ◽  
Yoshiya Tanaka ◽  
Sui Yung Chan ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Therapeutic Potential ◽  
Anti Inflammatory

scholarly journals Liposome/gold hybrid nanoparticle encoded with CoQ10 (LGNP-CoQ10) suppressed rheumatoid arthritis via STAT3/Th17 targeting

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0241080
Author(s):  
Jooyeon Jhun ◽  
Jeonghyeon Moon ◽  
Jaeyoon Ryu ◽  
Yonghee Shin ◽  
Seangyoun Lee ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Mononuclear Cells ◽  
Therapeutic Potential ◽  
Human Peripheral Blood ◽  
Treated Group ◽  
Hybrid Nanoparticles ◽  
Peripheral Blood Mononuclear ◽  
Hematoxylin And Eosin ◽  
Anti Inflammatory ◽  
Safranin O

Coenzyme Q10 (CoQ10), also known as ubiquinone, is a fat-soluble antioxidant. Although CoQ10 has not been approved as medication by the Food and Drug Administration, it is widely used in dietary supplements. Some studies have shown that CoQ10 has anti-inflammatory effects on various autoimmune disorders. In this study, we investigated the anti-inflammatory effects of liposome/gold hybrid nanoparticles encoded with CoQ10 (LGNP-CoQ10). Both CoQ10 and LGNP-CoQ10 were administered orally to mice with collagen-induced arthritis (CIA) for 10 weeks. The inflammation pathology of joint tissues of CIA mice was then analyzed using hematoxylin and eosin and Safranin O staining, as well as immunohistochemistry analysis. We obtained immunofluorescence staining images of spleen tissues using confocal microscopy. We found that pro-inflammatory cytokines were significantly decreased in LGNP-CoQ10 injected mice. Th17 cell and phosphorylated STAT3-expressed cell populations were also decreased in LGNP-CoQ10 injected mice. When human peripheral blood mononuclear cells (PBMCs) were treated with CoQ10 and LGNP-CoQ10, the IL-17 expression of PBMCs in the LGNP-CoQ10-treated group was significantly reduced. Together, these results suggest that LGNP-CoQ10 has therapeutic potential for the treatment of rheumatoid arthritis.

scholarly journals Therapeutic Potential of a Novel Bifidobacterium Identified Through Microbiome Profiling of RA Patients With Different RF Levels

2021 ◽  
Vol 12 ◽  
Author(s):  
Yunju Jeong ◽  
JooYeon Jhun ◽  
Seon-Yeong Lee ◽  
Hyun Sik Na ◽  
JeongWon Choi ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Relative Abundance ◽  
Th17 Cells ◽  
Mononuclear Cells ◽  
Therapeutic Potential ◽  
Human Peripheral Blood ◽  
Cartilage Damage ◽  
Therapeutic Effects ◽  
Bioinformatics Analyses ◽  
Proinflammatory Mediators

The potential therapeutic effects of probiotic bacteria in rheumatoid arthritis (RA) remain controversial. Thus, this study aimed to discover potential therapeutic bacteria based on the relationship between the gut microbiome and rheumatoid factor (RF) in RA. Bacterial genomic DNA was extracted from the fecal samples of 93 RA patients and 16 healthy subjects. Microbiota profiling was conducted through 16S rRNA sequencing and bioinformatics analyses. The effects of Bifidobacterium strains on human peripheral blood mononuclear cells and collagen-induced arthritis (CIA) mice were assessed. Significant differences in gut microbiota composition were observed in patients with different RF levels. The relative abundance of Bifidobacterium and Collinsella was lower in RF-high than in RF-low and RF-negative RA patients, while the relative abundance of Clostridium of Ruminococcaceae family was higher in RF-high than in RF-low and RF-negative patients. Among 10 differentially abundant Bifidobacterium, B. longum RAPO exhibited the strongest ability to inhibit IL-17 secretion. Oral administration of B. longum RAPO in CIA mice, obese CIA, and humanized avatar model significantly reduced RA incidence, arthritis score, inflammation, bone damage, cartilage damage, Th17 cells, and inflammatory cytokine secretion. Additionally, B. longum RAPO significantly inhibited Th17 cells and Th17-related genes—IL-17A, IRF4, RORC, IL-21, and IL-23R—in the PBMCs of rheumatoid arthritis patients. Our findings suggest that B. longum RAPO may alleviate RA by inhibiting the production of IL-17 and other proinflammatory mediators. The safety and efficacy of B. longum RAPO in patients with RA and other autoimmune disorders merit further investigation.

Therapeutic Potential of Mesenchymal Stromal Stem Cells in Rheumatoid Arthritis: a Systematic Review of In Vivo Studies

2020 ◽  
Vol 16 (2) ◽  
pp. 276-287 ◽  
Author(s):  
Alexia Karamini ◽  
Athina Bakopoulou ◽  
Dimitrios Andreadis ◽  
Konstantinos Gkiouras ◽  
Aristeidis Kritis
Keyword(s):  
Rheumatoid Arthritis ◽  
Systematic Review ◽  
Stem Cells ◽  
Therapeutic Potential ◽  
In Vivo Studies ◽  
Stromal Stem Cells
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