An End-to-End Integrated Clinical and CT Based Radiomics Nomogram for Predicting Disease Severity and Need for Ventilator Support in COVID-19 Patients: A Large Multi-Site Retrospective Study

2021 ◽  
Author(s):  
Pranjal Vaidya ◽  
Mehdi Alilou ◽  
Amogh Hiremath ◽  
Amit Gupta ◽  
Kaustav Bera ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Disease Severity ◽  
Ventilator Support ◽  
End To End

scholarly journals Serum magnesium levels in hospitalized patients with SARS-CoV-2

2021 ◽  
pp. jim-2021-001948
Author(s):  
Rupam Sharma ◽  
Arash Heidari ◽  
Royce H Johnson ◽  
Shailesh Advani ◽  
Greti Petersen
Keyword(s):  
Disease Severity ◽  
Chart Review ◽  
Medical Literature ◽  
Adverse Outcome ◽  
Serum Magnesium ◽  
Retrospective Chart Review ◽  
Descriptive Statistics ◽  
Ventilator Support ◽  
Adjusted Logistic Regression ◽  
Electrolyte Abnormalities

Early studies have reported various electrolyte abnormalities at admission in patients with severe COVID-19. 104 out of 193 patients admitted to our institution presented with hypermagnesemia at presentation. It is believed this may be important in the evaluation of severe SARS-CoV-2 infections. This study evaluated the outcomes of hypermagnesemia in patients with COVID-19. A retrospective chart review of patients admitted to the hospital with confirmed SARS-CoV-2 infection was conducted. A review of the medical literature regarding hypermagnesemia, magnesium levels in critical care illness and electrolyte abnormalities in patients with COVID-19 was performed. Differences in demographic and clinical characteristics of patients with hypermagnesemia and normomagnesemia were evaluated using descriptive statistics. Other known variables of disease severity were analyzed. 104 patients (54%) were identified with hypermagnesemia (≥2.5 mg/dL). 48 of those patients were admitted to the intensive care unit (46%, p<0.001). 34 patients required ventilator support (32%, p<0.0001). With age-adjusted logistic regression analysis hypermagnesemia was associated with mortality (p=0.007). This study demonstrates that hypermagnesemia is a significant marker of disease severity and adverse outcome in SARS-CoV-2 infections. We recommend serum magnesium be added to the panel of tests routinely ordered in evaluation of severe SARS-CoV-2 infections.

scholarly journals D Dimer – Prognostic indicator for disease severity in patients hospitalised with COVID 19

2021 ◽  
Vol 8 (4) ◽  
pp. 461-464
Author(s):  
Vineet Banga ◽  
Stuti Jain
Keyword(s):  
Retrospective Study ◽  
Disease Severity ◽  
Severe Disease ◽  
Prognostic Indicator ◽  
Clinical Severity ◽  
Care Hospital ◽  
Severity Of Disease ◽  
Management Protocol ◽  
Severity Levels ◽  
D Dimer

Patients of Covid 19 infections present with different severity. Levels of D Dimer in these patients can be correlated with disease severity for management and prognosis. To evaluate the usefulness of D-Dimer levels in blood to correlate with disease severity in COVID 19 patients. Retrospective study was done in Department of Pathology of Secondary Care hospital that became designated covid hospital from May 2021 to June 2021 on 60 COVID 19 positive admitted patients. D dimer levels were analysed and correlated with clinical severity of disease. Out of total 60 patients, 33 were in mild, 23 in moderate and 4 were in severe category. In mild cases D Dimer varies from 43 ng/ml to 183 ng/ml. In moderate cases D Dimer varies from 270 ng/ml to 991 ng/ml. In severe cases D Dimer varies from 1043 ng/ml to 2463 ng/ml. The study suggests cut off levels for D Dimer as up to 200 ng/ml for mild, 200-1000 ng/ml for moderate and more than 1000 ng/ml for severe category in COVID 19 patients. D dimer helps in identifying severe disease and can be used as an essential biomarker in developing the management protocol for COVID 19 patients.

scholarly journals Novel Coronavirus Infection: A Review on Haematological Markers of Disease Severity

2020 ◽  
Author(s):  
Angela Ogechukwu Ugwu ◽  
Theresa Ukamaka Nwagha
Keyword(s):  
Respiratory Failure ◽  
Disease Severity ◽  
White Cell Count ◽  
Strong Relationship ◽  
Ventilator Support ◽  
Increased Risk ◽  
Wide Range ◽  
Coronavirus Infection ◽  
Novel Coronavirus ◽  
Prophylactic Anticoagulation

The Corornavirus Disease (COVID-19) virus infection has a wide range of presentation- asymptomatic, mild, severe and critical forms that often lead to death from respiratory failure. There is a strong relationship between the severity of COVID-19 infection and some haematological parameters. Patients often present with lymphocytopenia at diagnosis despite having a normal total white cell count. The degree of lymphocytopenia could predict the progression to pneumonia and subsequent need for ventilator support due to respiratory failure. Apart from lymphocytopenia, thrombocytopenia has been linked with increased severity of COVID-19 symptoms. The lymphocyte-platelet ratio has been found to a better marker for disease severity than isolated lymphocytopenia or thrombocytopenia. COVID-19 patients have been found to be at increased risk of Venous Thromboembolism (VTE). There is elevation of D-dimers, abnormalities of the Prothrombin Time (PT) and activated Partial Thromboplastin Time (aPTT) among hospitalised COVID-19 patients. This has necessitated the use of prophylactic anticoagulation even in the early phases of the infection.

scholarly journals Validation of Predictors of Disease Severity and Outcomes in COVID-19 Patients: A Descriptive and Retrospective Study

Med ◽  
2020 ◽  
Vol 1 (1) ◽  
pp. 128-138.e3 ◽  
Author(s):  
Li Tan ◽  
Xia Kang ◽  
Xinran Ji ◽  
Gaoming Li ◽  
Qi Wang ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Disease Severity

scholarly journals A retrospective study of periodontal disease severity in smokers and non-smokers

BDJ ◽  
2005 ◽  
Vol 198 (8) ◽  
pp. 495-498 ◽  
Author(s):  
M Razali ◽  
R M Palmer ◽  
P Coward ◽  
R F Wilson
Keyword(s):  
Retrospective Study ◽  
Periodontal Disease ◽  
Disease Severity

scholarly journals Circulating Endothelial Cells as a Marker of Endothelial Injury in Severe COVID -19

2020 ◽  
Vol 222 (11) ◽  
pp. 1789-1793 ◽  
Author(s):  
Christophe Guervilly ◽  
Stephane Burtey ◽  
Florence Sabatier ◽  
Raphaël Cauchois ◽  
Guillaume Lano ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Intensive Care ◽  
Retrospective Study ◽  
Disease Severity ◽  
Inflammatory Cytokines ◽  
Endothelial Injury ◽  
Circulating Endothelial Cells ◽  
Vascular Events ◽  
Icu Patients

Abstract Beside the commonly described pulmonary expression of the coronavirus disease 2019 (COVID-19), major vascular events have been reported. The objective of this study was to investigate whether increased levels of circulating endothelial cells (CECs) might be associated with severe forms of COVID-19. Ninety-nine patients with COVID-19 were enrolled in this retrospective study. Patients in the intensive care units (ICU) had significantly higher CEC counts than non-ICU patients and the extent of endothelial injury was correlated with putative markers of disease severity and inflammatory cytokines. Together, these data provide in vivo evidence that endothelial injury is a key feature of COVID-19.

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