Comparison Between Calcaneus Quantitative Ultrasound and the Gold Standard DXA in the Ability to Detect Osteoporosis in COPD Patients

2021 ◽  
Author(s):  
Wandee Chanprasertpinyo ◽  
Chuchard Punsawad ◽  
Naparat Sukkriang ◽  
Pirada Yincharoen ◽  
Rapheeporn Khwanchuea ◽  
...  
2021 ◽  
Author(s):  
Wandee Chanprasertpinyo ◽  
Chuchard Punsawad ◽  
Naparat Sukkriang ◽  
Rapheeporn Khwanchuea ◽  
Pirada Yincharoen ◽  
...  

Abstract IntroductionOsteoporosis is a prevalent comorbidity in patients with COPD that is usually underrecognized and hence undertreated. Compared to the gold standard dual-energy X-ray absorptiometry (DXA), calcaneus quantitative ultrasound (QUS) is less expensive, more portable, and more accessible, especially in less developed countries. The aim of this study was to investigate the ability of calcaneus QUS to detect osteoporosis in patients with COPD.MethodsThis cross-sectional study enrolled 67 males older than 50 years with clinically stable COPD. DXA scans of the lumbar spine (L2-4) and femoral neck were performed. QUS of the right calcaneus (AOS-100) were used to assess the broadband ultrasound attenuation (BUA), speed of sound (SOS), osteo sono-assessment index (OSI), and T-score. When the T-score was ≤ − 2.5, osteoporosis was diagnosed by both DXA and QUS.ResultsForty-eight patients (71.6%) had DXA T-scores ≤ − 2.5 at either the lumbar spine or femoral neck. All QUS parameters (BUA, SOS, OSI, and T-score) could discriminate DXA-determined osteoporosis (the area under the curve varied from 0.64 to 0.83). The QUS T-score was significantly moderately correlated with the DXA T-score at both the femoral neck (r = 0.62) and lumbar spine (r = 0.53). The sensitivity and specificity of QUS in identifying osteoporosis were 10.4% and 94.7%, respectively. The positive and negative predictive values were 83.3% and 29.5%, respectively.ConclusionThe calcaneus QUS T-score had the ability to identify osteoporosis with an acceptable level of accuracy. However, the sensitivity and specificity of the QUS T-score were not sufficiently high to serve as an alternative diagnostic tool to DXA.


2014 ◽  
Vol 1002 ◽  
pp. 77-80
Author(s):  
Jun Feng Mao ◽  
Zhao Xia Mu ◽  
Yong Li

Requirement of artificial bone materials is high, which demands us to consider many factors of human body. Evidence exists that estrogen influences neuronal physiology and cognitive function. Bone mineral density has been proposed as a marker for cumulative estrogen exposure. This study examined whether choice reaction time (CRT) would be related to calcaneus quantitative ultrasound (QUS). 222 ethnic Han Chinese men were recruited. Besides age and body mass index (BMI), cigarette smoking, as an important environment factor influencing cognition and bone health, was included in covariants. Results showed that CRT performance was statistically significantly positively correlated with bone quality index (p < 0.01) and speed of sound (SOS) (p < 0.001) before controlling covariants. After adjustment for age, BMI, and smoking, CRT remained significantly related to SOS (p < 0.05). Our findings indicate that CRT may be associated with bone status, which suggests an effect of artificial bone on nervous system should be considered when it is produced.


2022 ◽  
pp. 875647932110702
Author(s):  
Minoo Najafi ◽  
Maryam Najafi ◽  
Mitra Mahdavi-Mazdeh ◽  
Sima Maziar ◽  
Abbas Ali Keshtkar ◽  
...  

Objective: Dual x-ray absorptiometry (DXA) is gold standard of bone densitometry, but quantitative ultrasound (QUS) of bone is less expensive and portable. This study was designed to assess its usefulness in secondary osteoporosis diagnosis. Materials and Methods: There were 200 secondary osteoporosis cases (rheumatoid arthritis, hemodialysis, kidney transplant patients, and levothyroxine users) and of those, their phalanx QUS results were compared with normal controls. Also, the QUS and DXA results were compared to find any correlation of these methods for diagnosing osteoporosis. Results: There was not significantly different results compared with normal controls, except for those of hemodialysis patients ( P = .00). Also, the comparison of QUS with DXA results showed no significant correlation except in hemodialysis patients, in both spinal and femoral regions ( P = .023 and .21, respectively), as well as the levothyroxine group’s spinal region ( P = .005). Conclusion: These results suggest that QUS of phalanx may be useful in screening secondary osteoporosis but for establishment of diagnosis, DXA measurements are still needed.


2006 ◽  
Vol 17 (8) ◽  
pp. 1216-1224 ◽  
Author(s):  
W. Liu ◽  
C. -L. Xu ◽  
Z. -Q. Zhu ◽  
W. Wang ◽  
S. -M. Han ◽  
...  

2017 ◽  
Vol 35 (4) ◽  
pp. 1249-1253
Author(s):  
Dejan M. Madic ◽  
Nebojsa Trajkovic ◽  
Boris Popovic ◽  
Danilo Radanovic ◽  
Goran Sporis

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