Increased Risk of Severe COVID-19 in Hospitalized Patients With SARS-CoV-2 Variant of Concern Alpha Infection in France: A Multicentre Matched Cohort Study With Retrospective Data Collection

2021 ◽  
Author(s):  
Guillaume Martin-Blondel ◽  
Fraçois-Xavier Lescure ◽  
Lambert Assoumou ◽  
Charlotte Charpentier ◽  
Jean-Marc Chapplain ◽  
...  
Keyword(s):  
Cohort Study ◽  
Data Collection ◽  
Hospitalized Patients ◽  
Retrospective Data ◽  
Matched Cohort ◽  
Matched Cohort Study ◽  
Increased Risk ◽  
Retrospective Data Collection

Excess Mortality Among Hospitalized Patients With Hypopituitarism—A Population-Based, Matched-Cohort Study

2020 ◽  
Vol 105 (11) ◽  
Author(s):  
Fahim Ebrahimi ◽  
Alexander Kutz ◽  
Ulrich Wagner ◽  
Ben Illigens ◽  
Timo Siepmann ◽  
...  
Keyword(s):  
Cohort Study ◽  
Hospital Mortality ◽  
Clinical Outcomes ◽  
Excess Mortality ◽  
Population Based ◽  
Hospitalized Patients ◽  
Matched Cohort ◽  
Prolonged Length ◽  
Matched Cohort Study ◽  
Increased Risk

Abstract Context Patients with hypopituitarism face excess mortality in the long-term outpatient setting. However, associations of pituitary dysfunction with outcomes in acutely hospitalized patients are lacking. Objective The objective of this work is to assess clinical outcomes of hospitalized patients with hypopituitarism with or without diabetes insipidus (DI). Design, Setting, and Patients In this population-based, matched-cohort study from 2012 to 2017, hospitalized adult patients with a history of hypopituitarism were 1:1 propensity score–matched with a general medical inpatient cohort. Main Outcome Measures The primary outcome was in-hospital mortality. Secondary outcomes included all-cause readmission rates within 30 days and 1 year, intensive care unit (ICU) admission rates, and length of hospital stay. Results After matching, 6764 cases were included in the study. In total, 3382 patients had hypopituitarism and of those 807 (24%) suffered from DI. All-cause in-hospital mortality occurred in 198 (5.9%) of patients with hypopituitarism and in 164 (4.9%) of matched controls (odds ratio [OR] 1.32, [95% CI, 1.06-1.65], P = .013). Increased mortality was primarily observed in patients with DI (OR 3.69 [95% CI, 2.44-5.58], P < .001). Patients with hypopituitarism had higher ICU admissions (OR 1.50 [95% CI, 1.30-1.74], P < .001), and faced a 2.4-day prolonged length of hospitalization (95% CI, 1.94–2.95, P < .001) compared to matched controls. Risk of 30-day (OR 1.31 [95% CI, 1.13-1.51], P < .001) and 1-year readmission (OR 1.29 [95% CI, 1.17-1.42], P < .001) was higher among patients with hypopituitarism as compared with medical controls. Conclusions Patients with hypopituitarism are highly vulnerable once hospitalized for acute medical conditions with increased risk of mortality and adverse clinical outcomes. This was most pronounced among those with DI.

scholarly journals COVID-19 severity in hospitalized patients with asthma: A matched cohort study

2020 ◽  
Author(s):  
Lacey B. Robinson ◽  
Xiaoqing Fu ◽  
Ingrid V. Bassett ◽  
Virginia A. Triant ◽  
Andrea S. Foulkes ◽  
...  
Keyword(s):  
Cohort Study ◽  
Hospitalized Patients ◽  
Matched Cohort ◽  
Matched Cohort Study

Increased risk of adhesive capsulitis among patients with gout: A nationwide population-based matched-cohort study

2018 ◽  
Vol 21 (9) ◽  
pp. 1716-1722 ◽  
Author(s):  
Kao-Chih Hsu ◽  
Chia-Hung Sun ◽  
Yin-Yin Wu ◽  
Liang-Cheng Chen ◽  
Yung-Tsan Wu ◽  
...  
Keyword(s):  
Cohort Study ◽  
Adhesive Capsulitis ◽  
Population Based ◽  
Matched Cohort ◽  
Matched Cohort Study ◽  
Increased Risk
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