Randomized Clinical Trial: Comparing In-Vitro Release of Growth Factors from Combination of Hyaluronic Acid and Advanced Platelet Rich Fibrin (A-PRF) Gel

2021 ◽  
Author(s):  
Ronald Winardi Kartika ◽  
Idrus Alwi ◽  
Franciscus D. Suyatna ◽  
Em Yunir ◽  
Sarwono Waspadji ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Hyaluronic Acid ◽  
Growth Factors ◽  
Randomized Clinical Trial ◽  
In Vitro Release ◽  
Platelet Rich Fibrin ◽  
Vitro Release

Novel Combinatorial Dexamethasone and Hyaluronic Acid Micro Particulate Injection for the Treatment of Hip Arthritis: Assesment in Rabbit Model

2021 ◽  
Vol 11 (1) ◽  
pp. 123-128
Author(s):  
Shiqiang Ma ◽  
Donghui Guo ◽  
Qiuling Shi ◽  
Xiaoming Li
Keyword(s):  
Hyaluronic Acid ◽  
In Vitro Release ◽  
Rabbit Model ◽  
Surface Characteristics ◽  
Regular Surface ◽  
Evaporation Technique ◽  
Aforementioned Study ◽  
Vitro Release ◽  
New Zealand Rabbits

The aforementioned study emphasis on formulation of Dexamethasone and Hyaluronic acid (DHA) loaded microspheres for intra-articulate injection at hip region to cure arthritic condition. DHA microspheres were formulated by solvent evaporation technique. The microspheres were found with smooth, regular surface characteristics. The loading and encapsulation efficiencies were also found higher. The in vitro release was found to be 15.12% for initial 24 hrs while 97.65% up to 25 days. Such microspheres were injected to hip region of Adult male new Zealand Rabbits (2.5–3 kg) to observe anti arthritic effect. The study result showed excellent ability of microsphere in order to treat arthritis. Therefore the results obtained concluded effectiveness of DHA microspheres in treating arthritic disease.

Hyaluronic acid-modified betamethasone encapsulated polymeric nanoparticles: fabrication, characterisation, in vitro release kinetics, and dermal targeting

2018 ◽  
Vol 9 (2) ◽  
pp. 520-533 ◽  
Author(s):  
Manisha Pandey ◽  
Hira Choudhury ◽  
Tarakini A. P. Gunasegaran ◽  
Saranyah Shanmugah Nathan ◽  
Shadab Md ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Polymeric Nanoparticles ◽  
Release Kinetics ◽  
In Vitro Release ◽  
Vitro Release

scholarly journals Quality-by-Design-Based Development of n-Propyl-Gallate-Loaded Hyaluronic-Acid-Coated Liposomes for Intranasal Administration

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1429
Author(s):  
Fakhara Sabir ◽  
Gábor Katona ◽  
Edina Pallagi ◽  
Dorina Gabriella Dobó ◽  
Hussein Akel ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Zeta Potential ◽  
Propyl Gallate ◽  
Quality By Design ◽  
In Vitro Release ◽  
Brain Diseases ◽  
Stability Studies ◽  
Accelerated Stability ◽  
Vitro Release

The present study aimed to develop n-propyl gallate (PG)-encapsulated liposomes through a novel direct pouring method using the quality-by-design (QbD) approach. A further aim was to coat liposomes with hyaluronic acid (HA) to improve the stability of the formulation in nasal mucosa. The QbD method was used for the determination of critical quality attributes in the formulation of PG-loaded liposomes coated with HA. The optimized formulation was determined by applying the Box–Behnken design to investigate the effect of composition and process variables on particle size, polydispersity index (PDI), and zeta potential. Physiochemical characterization, in vitro release, and permeability tests, as well as accelerated stability studies, were performed with the optimized liposomal formulation. The optimized formulation resulted in 90 ± 3.6% encapsulation efficiency, 167.9 ± 3.5 nm average hydrodynamic diameter, 0.129 ± 0.002 PDI, and −33.9 ± 4.5 zeta potential. Coated liposomes showed significantly improved properties in 24 h in an in vitro release test (>60%), in vitro permeability measurement (420 μg/cm2) within 60 min, and also in accelerated stability studies compared to uncoated liposomes. A hydrogen-peroxide-scavenging assay showed improved stability of PG-containing liposomes. It can be concluded that the optimization of PG-encapsulated liposomes coated with HA has great potential for targeting several brain diseases.

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