scholarly journals Accelerometer-Derived Sleep Onset Timing and Cardiovascular Disease Incidence: A UK Biobank Cohort Study

2021 ◽  
Author(s):  
Shahram Nikbakhtian ◽  
Angus Bruno Reed ◽  
Bernard Dillon Obika ◽  
Davide Morelli ◽  
Adam C. Cunningham ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cohort Study ◽  
Disease Incidence ◽  
Sleep Onset ◽  
Uk Biobank ◽  
Onset Timing ◽  
Cardiovascular Disease Incidence

scholarly journals Accelerometer-derived sleep onset timing and cardiovascular disease incidence: a UK Biobank cohort study

2021 ◽  
Author(s):  
Shahram Nikbakhtian ◽  
Angus B Reed ◽  
Bernard Dillon Obika ◽  
Davide Morelli ◽  
Adam C Cunningham ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
Disease Incidence ◽  
Sleep Onset ◽  
Onset Time ◽  
Sensitivity Analyses ◽  
Accelerometer Data ◽  
Uk Biobank ◽  
Onset Timing ◽  
Sleep Parameters

Aims Growing evidence suggests that sleep quality is associated with cardiovascular risk. However, research in this area often relies upon recollection dependant questionnaires or diaries. Accelerometers provide an alternative tool for deriving sleep parameters measuring sleep patterns objectively. This study examines the associations between accelerometer derived sleep onset timing and cardiovascular disease (CVD). Methods and Results We derived sleep onset and waking up time from accelerometer data collected from 103,712 UK Biobank participants over a period of seven days. From this, we examined the association between sleep onset timing and CVD incidence using a series of Cox proportional hazards models. 3172 cases of CVD were reported during a mean follow-up period of 5.7 (±0.49) years. An age- and sex-controlled base analysis found that sleep onset time of 10:00pm-10:59pm was associated with the lowest CVD incidence. A fully adjusted model, additionally controlling for sleep duration, sleep irregularity, and established CVD risk factors, was unable to eliminate this association, producing hazard ratios of 1.24 (95% CI, 1.10-1.39; p<0.005), 1.12 (1.01-1.25; p=0.04), and 1.25 (1.02-1.52; p=0.03) for sleep onset <10:00pm, 11:00pm-11:59pm, and & ≥12:00am, respectively, compared to 10:00pm-10:59pm. Importantly, sensitivity analyses revealed this association was stronger in females, with only sleep onset <10:00pm significant for males. Conclusions Our findings suggest an independent relationship between sleep onset timing and risk of developing CVD, particularly for women. We also demonstrate the potential utility of collecting information about sleep parameters via accelerometry-capable wearable devices, which may serve as novel cardiovascular risk indicators.

scholarly journals Cardiovascular Disease Incidence and Risk Factor Patterns among Omanis with Type 2 Diabetes: A Retrospective Cohort Study

2017 ◽  
Vol 32 (2) ◽  
pp. 106-114 ◽  
Author(s):  
Abdul Hakeem Al Rawahi ◽  
Patricia Lee ◽  
Zaher A.M. Al Anqoudi ◽  
Ahmed Al Busaidi ◽  
Muna Al Rabaani ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Risk Factor ◽  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Disease Incidence ◽  
Cardiovascular Disease Incidence

scholarly journals Accelerometer-derived sleep onset timing and cardiovascular disease incidence: a UK Biobank cohort study

2021 ◽  
Author(s):  
Shahram Nikbakhtian ◽  
Angus B Reed ◽  
Bernard Dillon Obika ◽  
Davide Morelli ◽  
Adam C Cunningham ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
Sleep Onset ◽  
Sensitivity Analyses ◽  
Poor Sleep ◽  
Accelerometer Data ◽  
Uk Biobank ◽  
Cvd Risk ◽  
Onset Timing ◽  
Sleep Parameters

Abstract Aims Growing evidence suggests that poor sleep health is associated with cardiovascular risk. However, research in this area often relies upon recollection dependent questionnaires or diaries. Accelerometers provide an alternative tool for measuring sleep parameters objectively. This study examines the association between wrist-worn accelerometer-derived sleep onset timing and cardiovascular disease (CVD). Methods and results We derived sleep onset and waking up time from accelerometer data collected from 103 712 UK Biobank participants over a period of 7 days. From this, we examined the association between sleep onset timing and CVD incidence using a series of Cox proportional hazards models. A total of 3172 cases of CVD were reported during a mean follow-up period of 5.7 (±0.49) years. An age- and sex-controlled base analysis found that sleep onset time of 10:00 p.m.–10:59 p.m. was associated with the lowest CVD incidence. An additional model, controlling for sleep duration, sleep irregularity, and established CVD risk factors, did not attenuate this association, producing hazard ratios of 1.24 (95% confidence interval, 1.10–1.39; P &lt; 0.005), 1.12 (1.01–1.25; P= 0.04), and 1.25 (1.02–1.52; P= 0.03) for sleep onset &lt;10:00 p.m., 11:00 p.m.–11:59 p.m., and ≥12:00 a.m., respectively, compared to 10:00 p.m.–10:59 p.m. Importantly, sensitivity analyses revealed this association with increased CVD risk was stronger in females, with only sleep onset &lt;10:00 p.m. significant for males. Conclusions Our findings suggest the possibility of a relationship between sleep onset timing and risk of developing CVD, particularly for women. We also demonstrate the potential utility of collecting information about sleep parameters via accelerometry-capable wearable devices, which may serve as novel cardiovascular risk indicators.

scholarly journals Neutrophil to Lymphocyte Ratio and Cardiovascular Disease Incidence in HIV-Infected Patients: A Population-Based Cohort Study

PLoS ONE ◽  
2016 ◽  
Vol 11 (5) ◽  
pp. e0154900 ◽  
Author(s):  
Eugenia Quiros-Roldan ◽  
Elena Raffetti ◽  
Francesco Donato ◽  
Michele Magoni ◽  
Chiara Pezzoli ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cohort Study ◽  
Disease Incidence ◽  
Population Based ◽  
Neutrophil To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Cardiovascular Disease Incidence
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