Mediterranean Diet Adherence, Gut Microbiota, and Alzheimer's or Parkinson's Disease Risk: A Systematic Review

2021 ◽  
Author(s):  
Rebecca Solch ◽  
Julia Aigbogun ◽  
Andrew Voyiadjis ◽  
Grant Talkington ◽  
Revonda Darensbourg ◽  
...  
Keyword(s):  
Systematic Review ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Gut Microbiota ◽  
Mediterranean Diet ◽  
Disease Risk ◽  
Diet Adherence ◽  
Mediterranean Diet Adherence

scholarly journals The association between Mediterranean diet adherence and Parkinson's disease

2012 ◽  
Vol 27 (6) ◽  
pp. 771-774 ◽  
Author(s):  
Roy N. Alcalay ◽  
Yian Gu ◽  
Helen Mejia-Santana ◽  
Lucien Cote ◽  
Karen S. Marder ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mediterranean Diet ◽  
Diet Adherence ◽  
Mediterranean Diet Adherence

Mediterranean diet adherence is related to reduced probability of prodromal Parkinson's disease

2018 ◽  
Vol 34 (1) ◽  
pp. 48-57 ◽  
Author(s):  
Maria I. Maraki ◽  
Mary Yannakoulia ◽  
Maria Stamelou ◽  
Leonidas Stefanis ◽  
Georgia Xiromerisiou ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mediterranean Diet ◽  
Diet Adherence ◽  
Mediterranean Diet Adherence

scholarly journals Mediterranean Diet Adherence in People With Parkinson's Disease Reduces Constipation Symptoms and Changes Fecal Microbiota After a 5-Week Single-Arm Pilot Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Carley Rusch ◽  
Matthew Beke ◽  
Lily Tucciarone ◽  
Carmelo Nieves ◽  
Maria Ukhanova ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Weight Loss ◽  
Parkinson's Disease ◽  
Microbial Communities ◽  
Mediterranean Diet ◽  
Intestinal Permeability ◽  
Diet Intervention ◽  
Diet Adherence ◽  
Mediterranean Diet Adherence ◽  
Stool Samples

Introduction: Non-motor symptoms of Parkinson's disease (PD) such as gastrointestinal (GI) dysfunction are common, yet little is known about how modifying dietary intake impacts PD symptoms. The aim of this study in individuals with PD was to determine whether a Mediterranean diet intervention is feasible and affects GI function, intestinal permeability and fecal microbial communities.Methods: A single-arm, 5-week Mediterranean diet intervention study was conducted in eight people with PD. Daily and weekly questionnaires were administered to determine changes in GI symptoms. Urine and stool samples were collected at baseline and after 5 weeks to assess intestinal permeability and fecal microbial communities. Additionally, live-in partners of the participants with PD were matched as controls (n = 8) for baseline urine and stool samples.Results: Participants with PD increased intake of Mediterranean diet based on adherence scores from baseline to week 5 (4.4 ± 0.6 vs. 11.9 ± 0.7; P < 0.01 with >10 representing good adherence), which was linked with weight loss (77.4 kg vs. 74.9 kg, P = 0.01). Constipation syndrome scores decreased after 5 weeks (2.3 ± 0.5 vs. 1.5 ± 0.3; P = 0.04). Bilophila, was higher at baseline in PD (0.6 ± 0.1% vs. 0.2 ± 0.1% P = 0.02) and slightly decreased after the diet intervention (0.5 ± 0.1%; P = 0.01). Interestingly, the proportion of Roseburia was significantly lower in PD compared to controls (0.6 ± 0.2% vs. 1.6 ± 0.3%; P = 0.02) and increased at week 5 (0.9 ± 0.2%; P < 0.01). No differences were observed for markers of intestinal permeability between the control and PD groups or post-intervention.Conclusions: Short-term Mediterranean diet adherence is feasible in participants with PD; correlated with weight loss, improved constipation, and modified gut microbiota.Clinical Trial Registration:ClinicalTrials.gov, identifier: NCT03851861.

scholarly journals MIND diet associated with later onset of Parkinson's disease

2020 ◽  
Author(s):  
Avril Metcalfe-Roach ◽  
Adam Yu ◽  
Ella Golz ◽  
Kristen Sundvick ◽  
Mihai Cirstea ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mediterranean Diet ◽  
Dietary Habits ◽  
Age Of Onset ◽  
Disease Onset ◽  
Cross Sectional ◽  
Diet Adherence ◽  
The Mind ◽  
Mind Diet

Background: The MIND diet has been linked with prevention of Alzheimer's disease and cognitive decline but has not been fully assessed in the context of Parkinson's disease (PD). Objective: To determine whether MIND diet adherence is associated with the age of Parkinson's disease onset in a manner superior to that of the Mediterranean diet. Methods: Food Frequency Questionnaires from 167 participants with PD and 119 controls were scored for MIND and two versions of Mediterranean diet adherence. Scores were compared between sex and disease subgroups, and PD diet adherence was correlated with age of onset using univariate and multivariate linear models. Results: The female subgroup adhered more closely to the MIND diet than the males, and diet scores were not modified by disease status. Later age of onset correlated most strongly with MIND diet adherence in the female subgroup, corresponding to differences of up to 17.4 years (p<0.001) between low and high dietary tertiles. Greek Mediterranean adherence was also significantly associated with later PD onset across all models (p=0.05-0.03). Conversely, only Greek Mediterranean adherence remained correlated with later onset across all models in men, with differences of up to 8.4 years (p=0.002). Conclusions: This cross-sectional study finds a strong correlation of age of onset of PD with dietary habits, suggesting that nutritional strategies may be an effective tool to delay PD onset. Further studies may help to elucidate potential nutrition-related sex-specific pathophysiological mechanisms and differential prevalence rates in PD.

Gut microbiota differences between healthy older adults and individuals with Parkinson’s disease: A systematic review

2020 ◽  
Vol 112 ◽  
pp. 227-241 ◽  
Author(s):  
Nathan D. Nuzum ◽  
Amy Loughman ◽  
Ewa A. Szymlek-Gay ◽  
Ashlee Hendy ◽  
Wei-Peng Teo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Older Adults ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Gut Microbiota ◽  
Healthy Older Adults

scholarly journals Association of the Modified Mediterranean Diet Score (mMDS) with Anthropometric and Biochemical Indices in US Career Firefighters

Nutrients ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3693
Author(s):  
Maria Romanidou ◽  
Grigorios Tripsianis ◽  
Maria Soledad Hershey ◽  
Mercedes Sotos-Prieto ◽  
Costas Christophi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Mediterranean Diet ◽  
Disease Risk ◽  
Controlled Trial ◽  
Cardiovascular Disease Risk ◽  
Mediterranean Diet Score ◽  
Diet Adherence ◽  
Mediterranean Diet Adherence ◽  
The Mediterranean ◽  
Diet Score

The Mediterranean diet is associated with multiple health benefits, and the modified Mediterranean Diet Score (mMDS) has been previously validated as a measure of Mediterranean diet adherence. The aim of this study was to examine associations between the mMDS and anthropometric indices, blood pressure, and biochemical parameters in a sample of career firefighters. The participants were from Indiana Fire Departments, taking part in the “Feeding America’s Bravest” study, a cluster-randomized controlled trial that aimed to assess the efficacy of a Mediterranean diet intervention. We measured Mediterranean diet adherence using the mMDS. Anthropometric, blood pressure, and biochemical measurements were also collected. Univariate and multivariate linear regression models were used. In unadjusted analyses, many expected favorable associations between the mMDS and cardiovascular disease risk factors were found among the 460 firefighters. After adjustment for age, gender, ethnicity, physical activity, and smoking, a unitary increase in the mMDS remained associated with a decrease of the total cholesterol/HDL ratio (β-coefficient −0.028, p = 0.002) and an increase of HDL-cholesterol (β-coefficient 0.254, p = 0.004). In conclusion, greater adherence to the Mediterranean diet was associated with markers of decreased cardiometabolic risk. The mMDS score is a valid instrument for measuring adherence to the Mediterranean diet and may have additional utility in research and clinical practice.

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