Epidemic Healthcare-Associated Pediatric HIV Infection from Parenteral Drug Administration, Pakistan 2019

2021 ◽  
Author(s):  
Muhammad Asif Syed ◽  
Adnan Khan ◽  
Ambreen Chaudhry ◽  
Mirza Amir Baig ◽  
Naveed Masood Memon ◽  
...  
Circulation ◽  
1995 ◽  
Vol 92 (8) ◽  
pp. 2220-2225 ◽  
Author(s):  
Steven E. Lipshultz ◽  
E. John Orav ◽  
Stephen P. Sanders ◽  
Steven D. Colan

1999 ◽  
Vol 13 (10) ◽  
pp. 587-599 ◽  
Author(s):  
DOUGLAS C. WATSON ◽  
TERESA L. COLLINS-JONES ◽  
SUSAN LOVELACE

Author(s):  
Biobele J. Brown ◽  
Regina E. Oladokun ◽  
Babatunde O. Ogunbosi ◽  
Kikelomo Osinusi

Introduction: This study describes the epidemiologic features and clinical course of children with blood transfusion-associated HIV infection (TAHI) in Ibadan, Nigeria. Methodology: All children diagnosed to have TAHI at the University College Hospital, Ibadan, were studied and compared with children who acquired HIV vertically using the pediatric HIV database in the hospital. Results: Transfusion-associated HIV infection accounted for 14 (2.3%) of the 597 children diagnosed to have HIV infection between January 2004 and December 2011. The mean age at diagnosis of TAHI was 10.2 years and that of vertically acquired HIV infection was 3.9 years ( P < .001). In 9 cases, blood transfusion took place in private hospitals and in 5 cases in public hospitals. Median interval between infection and diagnosis of AIDS was 84 months in cases with TAHI and 48 months in vertically acquired cases ( P = .542). Conclusion: Optimal blood safety practices are advocated for prevention of TAHI in Nigeria.


PEDIATRICS ◽  
1992 ◽  
Vol 90 (1) ◽  
pp. 99-102
Author(s):  
ALAN MEYERS ◽  
NICHOLAS PEPE ◽  
WILLIAM CRANLEY ◽  
KATHLEEN MCCARTEN

The early diagnosis of infection with the human immunodeficiency virus (HIV) in infancy is clinically important but remains problematic in the asymptomatic child born to an HIV-infected mother. In addition, many such women are unaware of their HIV infection until their child manifests symptomatic HIV disease. Nonspecific signs of pediatric HIV infection, such as generalized lymphadenopathy, hepatosplenomegaly, or persistent thrush, may be important in alerting the clinician to consider the possibility of HIV infection in the child whose history of HIV risk is unknown. We report one such sign which may be evident on plain chest radiography. The pathology of the thymus gland in pediatric acquired immunodeficiency syndrome has been described by Joshi and colleagues,1-3 who have reported precocious involution with marked reduction in thymus size and weight.


PEDIATRICS ◽  
1992 ◽  
Vol 89 (4) ◽  
pp. 791-794
Author(s):  

PERINATAL INFECTIONS The primary route of human immunodeficiency virus (HIV) infection in infants is vertical transmission from HIV-infected mothers. This is of particular concern as the number of infected women and the number of children infected by perinatal transmission continue to increase rapidly. The number of perinatally acquired acquired immunodeficiency syndrome (AIDS) cases increased 17% in 1989 and 21% in 1990. Similarly, the number of heterosexually acquired AIDS cases increased 27% in 1989 and 40% in 1990. There is evidence that vertical transmission of HIV can occur in utero (congenital/transplacental, similar to rubella),1,2 in the postpartum period (breast-feeding), and perhaps in the intrapartum period (similar to hepatitis B).3 The relative frequency and efficiency of transmission during each of these periods remains uncertain. The best estimates of vertical transmission from an HIV-seropositive mother to the fetus range from 12.9% to 39%4-6 Although the risk of transmission appears to be increased in women who are symptomatic, this point is still unclear.5 Preliminary information suggests that the presence of high levels of high-affinity/avidity antibodies to specific epitopes of the gp 120 of HIV may be protective and may decrease or prevent vertical transmission,7-10 although others have not been able to confirm this finding.11 More detailed information on perinatal HIV infection,12 and infection control13 in pediatric HIV infection is available in previously published statements from the AAP Task Force on Pediatric AIDS. SEROPREVALENCE Anonymous seroprevalence data from newborn specimens are being collected in 44 states, Puerto Rico, and the District of Columbia. In some states, seroprevalence data are available by metropolitan area and/or by hospital of birth.


2017 ◽  
Vol 2 (2) ◽  
Author(s):  
Jean-François Bussières

AbstractThe objective of this paper was to present 12 examples of the challenges of parenteral drug administration that hospital pharmacists and other clinicians face. These examples were presented as part of a talk during the International Symposium on Infusion Technologies in November 2016. Issues included the safety and compatibility of syringes, filtration, smart pumps, beyond-use dates, closed-system transfer devices, risk measurement, traceability and labeling.


2017 ◽  
Vol 07 (04) ◽  
pp. 260-268
Author(s):  
F. Agbeko ◽  
T. Guedehoussou ◽  
K. D. Azoumah ◽  
O. E. Takassi ◽  
M. Fiawoo ◽  
...  

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