Dissecting the Functional Selectivity of TGFβ Signaling Pathway Components Using Genome Engineered Human Organotypic Skin Models

2021 ◽  
Author(s):  
Zilu Ye ◽  
Gülcan Kilic ◽  
Sally Dabelsteen ◽  
Irina Nikolaeva Marinova ◽  
Jens Frederik Bang Thøfner ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Functional Selectivity ◽  
Tgfβ Signaling ◽  
Tgfβ Signaling Pathway

scholarly journals The TGFβ-signaling pathway and colorectal cancer: associations between dysregulated genes and miRNAs

2018 ◽  
Vol 16 (1) ◽  
Author(s):  
Andrew J. Pellatt ◽  
Lila E. Mullany ◽  
Jennifer S. Herrick ◽  
Lori C. Sakoda ◽  
Roger K. Wolff ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Signaling Pathway ◽  
Tgfβ Signaling ◽  
Tgfβ Signaling Pathway

scholarly journals Transforming Growth Factor-Beta (TGFβ) Signaling Pathway in Cholangiocarcinoma

Cells ◽  
2019 ◽  
Vol 8 (9) ◽  
pp. 960 ◽  
Author(s):  
Panagiotis Papoutsoglou ◽  
Corentin Louis ◽  
Cédric Coulouarn
Keyword(s):  
Growth Factor ◽  
Signaling Pathway ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Tgfβ Signaling ◽  
Efficient Treatment ◽  
Tumor Onset ◽  
Tgfβ Signaling Pathway

Cholangiocarcinoma is a deadly cancer worldwide, associated with a poor prognosis and limited therapeutic options. Although cholangiocarcinoma accounts for less than 15% of liver primary cancer, its silent nature restricts early diagnosis and prevents efficient treatment. Therefore, it is of clinical relevance to better understand the molecular basis of cholangiocarcinoma, including the signaling pathways that contribute to tumor onset and progression. In this review, we discuss the genetic, molecular, and environmental factors that promote cholangiocarcinoma, emphasizing the role of the transforming growth factor β (TGFβ) signaling pathway in the progression of this cancer. We provide an overview of the physiological functions of TGFβ signaling in preserving liver homeostasis and describe how advanced cholangiocarcinoma benefits from the tumor-promoting effects of TGFβ. Moreover, we report the importance of noncoding RNAs as effector molecules downstream of TGFβ during cholangiocarcinoma progression, and conclude by highlighting the need for identifying novel and clinically relevant biomarkers for a better management of patients with cholangiocarcinoma.

scholarly journals lon-1 Regulates Caenorhabditis elegans Body Size Downstream of the dbl-1 TGFβ Signaling Pathway

2002 ◽  
Vol 246 (2) ◽  
pp. 418-428 ◽  
Author(s):  
Lisa L. Maduzia ◽  
Tina L. Gumienny ◽  
Cole M. Zimmerman ◽  
Huang Wang ◽  
Pradnya Shetgiri ◽  
...  
Keyword(s):  
Body Size ◽  
Caenorhabditis Elegans ◽  
Signaling Pathway ◽  
Tgfβ Signaling ◽  
Tgfβ Signaling Pathway

scholarly journals Alterations in the TGFβ signaling pathway in myogenic progenitors with age

Aging Cell ◽  
2004 ◽  
Vol 3 (6) ◽  
pp. 353-361 ◽  
Author(s):  
Marjorie L. Beggs ◽  
Radhakrishnan Nagarajan ◽  
Jane M. Taylor-Jones ◽  
Greg Nolen ◽  
Melanie MacNicol ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Tgfβ Signaling ◽  
Tgfβ Signaling Pathway

Transcription Pausing Regulates Hematopoietic Stem Cell Emergence through Fine-Tuning of Signaling Pathways

Blood ◽  
2015 ◽  
Vol 126 (23) ◽  
pp. 2379-2379
Author(s):  
Qiwen Yang ◽  
Xiuli Liu ◽  
Ting Zhou ◽  
Jennifer Cook ◽  
Kim Nguyen ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Signaling Pathway ◽  
Transcription Elongation ◽  
Tgfβ Signaling ◽  
Basal Transcription ◽  
Hematopoietic Stem ◽  
Pol Ii ◽  
Pol Ii Pausing ◽  
Vertebrate Embryos ◽  
Tgfβ Signaling Pathway

Abstract Regulation of RNA polymerase II (Pol II)-mediated gene transcription is a fundamental mechanism to control cell fate during developmental organogenesis, including the emergence of hematopoietic stem cells (HSCs) in vertebrate embryos. Increasing evidences in recent years have demonstrated that transcriptionally engaged Pol II often pauses shortly after initiation by pausing factors such as DSIF and NELF, and requires positive elongation factors such as P-TEFb for pause release. How this pause-to-elongation transition contributes to HSC development is largely unknown. In a zebrafish spt5 mutant, we detected a dramatic loss of HSCs in early embryos. Spt5 is a key subunit of DSIF, which plays a dual role in both Pol II pausing and elongation. The mutation of the zebrafish spt5 mutant has been reported to specifically disrupt the pausing function of DSIF. Similarly, reduction of HSCs was also detected in embryos lacking the other pausing factor NELF. Consistent with the loss-of-pausing in Spt5- and NELF-deficient embryos, we found that the HSC defect could be rescued by inhibiting Pol II pause-to-elongation transition with either P-TEFb inhibitors or knockdown of the P-TEFb subunit cdk9. Intriguingly, we identified that two essential signaling pathways involved in HSC development, the TGFβ signaling pathway and the JAK-STAT mediated proinflammation pathway, were oppositely regulated by Pol II pausing. In spt5 mutant embryos, the TGFβ signaling pathway is upregulated with an enhanced transcription elongation at several TGFβ signaling regulators, as revealed by Pol II ChIP assays; whereas the transcription of multiple genes involved in proinflammation signaling pathways, especially the genes regulating the interferon signaling, are downregulated. Pol II ChIP and nucleosome mapping studies revealed an increase of nucleosome occupancy at the promoters of proinflammation genes, leading to attenuated transcription initiation. These results suggest that paused Pol II can compete with nucleosomes for occupancy on some promoters to maintain accessible chromatin thus the basal transcription level of these genes. Consistent with the change of signaling activity, the HSC defect in mutant embryos could be effectively rescued by TGFβ inhibitors or by activation of JAK-STAT, the downstream effector of IFNγ signaling. Thus Pol II pausing affects HSC emergence through differentially regulating the transcription of distinct signaling regulators: while they negatively regulate the HSC inhibitory signaling (such as TGFβ) by preventing premature transcription elongation, they are also required to maintain the basal transcription of HSC-promoting signaling (such as the inflammation signaling) by preventing promoter nucleosome reassembly. In summary, our study suggests that Pol II pausing/elongation regulators and developmental signals converge at the paused Pol II to regulate HSC emergence in vertebrate embryos. Disclosures No relevant conflicts of interest to declare.

Modularized Smad-regulated TGFβ signaling pathway

2012 ◽  
Vol 240 (2) ◽  
pp. 187-200 ◽  
Author(s):  
Yongfeng Li ◽  
Minli Wang ◽  
Claudio Carra ◽  
Francis A. Cucinotta
Keyword(s):  
Signaling Pathway ◽  
Tgfβ Signaling ◽  
Tgfβ Signaling Pathway
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