Development and Multicenter External Validation of FIB-6; A Novel, Machine-Learning, Simple Bedside Score to Rule Out Severe Liver Fibrosis and Cirrhosis in Patients with Chronic Hepatitis C

2021 ◽  
Author(s):  
Gamal Shiha ◽  
Reham Soliman ◽  
Nabiel Mikhail ◽  
Khalid Alswat ◽  
Ayman Abdo ◽  
...  
Keyword(s):  
Machine Learning ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
External Validation ◽  
Severe Liver ◽  
Simple Bedside ◽  
Rule Out

Serum Immunoreactive Collagen IV detected by Monoclonal Antibodies as a Marker of Severe Fibrosis in Patients with Non- Alcoholic Fatty Liver Disease

2015 ◽  
Vol 24 (1) ◽  
pp. 61-68 ◽  
Author(s):  
Yuta Aida ◽  
Hiroshi Abe ◽  
Yoichi Tomita ◽  
Tomohisa Nagano ◽  
Nobuyoshi Seki ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Collagen Iv ◽  
Severe Liver ◽  
Alcoholic Fatty Liver ◽  
Serum Collagen ◽  
Alcoholic Fatty Liver Disease ◽  
Severe Fibrosis

Background & Aims: The incidence of non-alcoholic fatty liver disease (NAFLD) is increasing worldwide. We evaluated serum collagen IV as a direct non-invasive marker of severe liver fibrosis in NAFLD.Methods: The study included 148 NAFLD and 187 chronic hepatitis C patients in whom histological severity of liver fibrosis was evaluated. The utility of serum collagen IV measured by immune-mediated agglutination using two types of monoclonal antibodies for distinguishing severe fibrosis (≥ stage 3 and ≥ F3) from non-to-moderate fibrosis in NAFLD or chronic hepatitis C was assessed in comparison to serum hyaluronic acid or other indirect fibrosis markers.Results: Multiple logistic regression analysis showed that serum collagen IV was significantly associated with severe fibrosis in NAFLD (odds ratio: 1.21, p<0.001) but not in chronic hepatitis C. For distinguishing severe fibrosis in NAFLD, collagen IV showed the largest area under the receiver-operating characteristic curve (0.827, 95%CI: 0.746-0.908) followed by FIB-4 (0.805, 95%CI: 0.728-0.890); in chronic hepatitis C, those for FIB-4 (0.813, 95%CI: 0.748-0.878) and collagen IV (0.770, 95%CI: 0.683-0.857) were the largest and smallest, respectively. To detect severe fibrosis in NAFLD, a cutoff of collagen IV > 177 exhibited 77.1% sensitivity, 84.0% specificity, 76.5% positive predictive value, and 84.0% negative predictive value. Combined with a cutoff of FIB-4 > 2.09, the negative and positive predictive values, and specificity for detecting severe fibrosis in NAFLD increased further.Conclusion: Collagen IV is a reliable marker for distinguishing severe liver fibrosis from non-to-moderate fibrosis in NAFLD but not chronic hepatitis C.

Incidence and Predictors of Severe Liver Fibrosis in HIV-Infected Patients with Chronic Hepatitis C in Brazil

2008 ◽  
Vol 22 (9) ◽  
pp. 701-707 ◽  
Author(s):  
Maria Cássia Mendes-Correa ◽  
Azzo Widman ◽  
Maria Luiza Paes Brussi ◽  
Cristina Fátima Guastini ◽  
Reinaldo José Gianini
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Severe Liver

Independent predictors of severe liver fibrosis in chronic hepatitis C

2001 ◽  
Vol 120 (5) ◽  
pp. A369
Author(s):  
Mohamed A. Metwally ◽  
Paul Angulo ◽  
Claudia C. Zein ◽  
Nizar N. Zein
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Severe Liver

Independent predictors of severe liver fibrosis in chronic hepatitis C

2001 ◽  
Vol 120 (5) ◽  
pp. A369-A369
Author(s):  
M METWALLY ◽  
P ANGULO ◽  
C ZEIN ◽  
N ZEIN
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Severe Liver
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