Bariatric Surgery Improves Glycemia But Not Obesity in a Family with Inactive Melanocortin 4 Receptor Signaling

2021 ◽  
Author(s):  
Ronit Grinbaum ◽  
Nahum Begblaibter ◽  
Stella Mitrani-Rosenbaum ◽  
Lee M. Kaplan ◽  
Danny Ben-Zvi
Keyword(s):  
Bariatric Surgery ◽  
Receptor Signaling ◽  
Melanocortin 4 Receptor

scholarly journals Melanocortin 4 receptor signaling in dopamine 1 receptor neurons is required for procedural memory learning

2012 ◽  
Vol 106 (2) ◽  
pp. 201-210 ◽  
Author(s):  
Huxing Cui ◽  
Brittany L. Mason ◽  
Charlotte Lee ◽  
Akinori Nishi ◽  
Joel K. Elmquist ◽  
...  
Keyword(s):  
Procedural Memory ◽  
Receptor Signaling ◽  
Melanocortin 4 Receptor ◽  
Receptor Neurons

scholarly journals Serotonin 2C Receptor Agonists Improve Type 2 Diabetes via Melanocortin-4 Receptor Signaling Pathways

2007 ◽  
Vol 6 (5) ◽  
pp. 398-405 ◽  
Author(s):  
Ligang Zhou ◽  
Gregory M. Sutton ◽  
Justin J. Rochford ◽  
Robert K. Semple ◽  
Daniel D. Lam ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Signaling Pathways ◽  
Receptor Signaling ◽  
Serotonin 2C Receptor ◽  
Receptor Agonists ◽  
Melanocortin 4 Receptor

scholarly journals Activation of the Melanocortin-4 receptor signaling by α-MSH stimulates nerve-dependent mouse digit regeneration

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Hanqian Xu ◽  
Hailin Zhang ◽  
Yanqing Fang ◽  
Huiran Yang ◽  
Ying Chen ◽  
...  
Keyword(s):  
Adult Mouse ◽  
Receptor Signaling ◽  
Nail Matrix ◽  
Peripheral Organs ◽  
Melanocortin 4 Receptor ◽  
Limb Muscles ◽  
Mouse Limb ◽  
Digit Regeneration ◽  
And Function

Abstract Background Expression of Mc4r in peripheral organs indicates it has broader roles in organ homeostasis and regeneration. However, the expression and function of Mc4r in the mouse limb and digit has not been fully investigated. Our previous work showed that Mc4r−/− mice fail to regenerate the digit, but whether activation of MC4R signaling could rescue digit regeneration, or stimulate proximal digit regeneration is not clear. Results We analyzed the expression dynamics of Mc4r in the embryonic and postnatal mouse limb and digit using the Mc4r-gfp mice. We found that Mc4r-GFP is mainly expressed in the limb nerves, and in the limb muscles that are undergoing secondary myogenesis. Expression of Mc4r-GFP in the adult mouse digit is restricted to the nail matrix. We also examined the effect of α-MSH on mouse digit regeneration. We found that administration of α-MSH in the Mc4r+/− mice rescue the delayed regeneration of distal digit tip. α-MSH could rescue distal digit regeneration in denervated hindlimbs. In addition, α-MSH could stimulate regeneration of the proximally amputated digit, which is non-regenerative. Conclusions Mc4r expression in the mouse limb and digit is closely related to nerve tissues, and α-MSH/MC4R signaling has a neurotrophic role in mouse digit tip regeneration.

scholarly journals Weight and Glycemic Control Outcomes of Bariatric Surgery and Pharmacotherapy in Patients With Melanocortin-4 Receptor Deficiency

2022 ◽  
Vol 12 ◽  
Author(s):  
Esphie Grace Fodra Fojas ◽  
Saradalekshmi Koramannil Radha ◽  
Tomader Ali ◽  
Evan P. Nadler ◽  
Nader Lessan
Keyword(s):  
Bariatric Surgery ◽  
Weight Loss ◽  
Glycemic Control ◽  
Therapeutic Interventions ◽  
Control Group ◽  
Short Term ◽  
Melanocortin 4 Receptor ◽  
Significant Difference

BackgroundMelanocortin-4 receptor (MC4R) mutations are the most common of the rare monogenic forms of obesity. However, the efficacy of bariatric surgery (BS) and pharmacotherapy on weight and glycemic control in individuals with MC4R deficiency (MC4R-d) is not well-established. We investigated and compared the outcomes of BS and pharmacotherapy in patients with and without MC4R-d.MethodsPertinent details were derived from the electronic database among identified patients who had BS with MC4R-d (study group, SG) and wild-type controls (age- and sex-matched control group, CG). Short- and long-term outcomes were reported for the SG. Short-term outcomes were compared between the two groups.ResultsSeventy patients were screened for MC4R-d. The SG [six individuals (four females, two males); 18 (10–27) years old at BS; 50.3 (41.8–61.9) kg/m2 at BS, three patients with homozygous T162I mutations, two patients with heterozygous T162I mutations, and one patient with heterozygous I170V mutation] had a follow-up duration of up to 10 years. Weight loss, which varied depending on mutation type [17.99 (6.10–22.54) %] was stable for 6 months; heterogeneity of results was observed thereafter. BS was found superior to liraglutide on weight and glycemic control outcomes. At a median follow-up of 6 months, no significant difference was observed on weight loss (20.8% vs. 23.0%, p = 0.65) between the SG and the CG [eight individuals (four females, four males); 19.0 (17.8–36.8) years old at BS, 46.2 (42.0–48.3) kg/m2 at BS or phamacotherapeutic intervention]. Glycemic control in patients with MC4R-d and Type 2 diabetes improved post-BS.ConclusionOur data indicate efficacious short-term but varied long-term weight loss and glycemic control outcomes of BS on patients with MC4R-d, suggesting the importance of ongoing monitoring and complementary therapeutic interventions.

scholarly journals Melanocortin-4 Receptor Signaling Is Required for Weight Loss after Gastric Bypass Surgery

2012 ◽  
Vol 97 (6) ◽  
pp. E1023-E1031 ◽  
Author(s):  
Ida J. Hatoum ◽  
Nicholas Stylopoulos ◽  
Amanda M. Vanhoose ◽  
Kelli L. Boyd ◽  
Deng Ping Yin ◽  
...  
Keyword(s):  
Weight Loss ◽  
Gastric Bypass ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Receptor Signaling ◽  
Melanocortin 4 Receptor

scholarly journals Regulation of Melanocortin-4 Receptor Signaling: Agonist-Mediated Desensitization and Internalization

Endocrinology ◽  
2003 ◽  
Vol 144 (4) ◽  
pp. 1301-1314 ◽  
Author(s):  
Hiroshi Shinyama ◽  
Hiroaki Masuzaki ◽  
Hui Fang ◽  
Jeffrey S. Flier
Keyword(s):  
Receptor Signaling ◽  
Melanocortin 4 Receptor
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