Mitochondrial Origin of Cytosolic Protein Aggregation

2021 ◽  
Author(s):  
Qingqing Liu ◽  
Benjamin Fong ◽  
Jay R. Unruh ◽  
Fengli Guo ◽  
Kausik Si ◽  
...  
Keyword(s):  
Protein Aggregation ◽  
Cytosolic Protein ◽  
Mitochondrial Origin

An Ultra-Structural Study of Human Melanoma in Vivo and Vitro

1976 ◽  
Vol 34 ◽  
pp. 258-259
Author(s):  
James R. Gaylor ◽  
Fredda Schafer ◽  
Robert E. Nordquist
Keyword(s):  
Endoplasmic Reticulum ◽  
Golgi Apparatus ◽  
Protein Aggregation ◽  
Structural Study ◽  
Human Melanoma ◽  
Protein Matrix ◽  
Early Form ◽  
Endoplasmic Reticulum Protein ◽  
Mitochondrial Origin

Several theories on the origin of the melanosome exist. These include the Golgi origin theory, in which a tyrosinase-rich protein is "packaged" by the Golgi apparatus, thus forming the early form of the melanosome. A second theory postulates a mitochondrial origin of melanosomes. Its author contends that the melanosome is a modified mitochondria which acquires melanin during its development. A third theory states that a pre-melanosome is formed in the smooth or rough endoplasmic reticulum. Protein aggregation is suggested by one author as a possible source of the melanosome. This fourth theory postulates that the melanosome originates when the protein products of several genetic loci aggregate in the cytoplasm of the melanocyte. It is this protein matrix on which the melanin is deposited. It was with these theories in mind that this project was undertaken.

scholarly journals Stress-induced NEDDylation promotes cytosolic protein aggregation through HDAC6 in a p62-dependent manner

iScience ◽  
2021 ◽  
Vol 24 (3) ◽  
pp. 102146 ◽  
Author(s):  
Soyeon Kim ◽  
Mira Kwon ◽  
Yiseul Hwang ◽  
Junghyun Yoon ◽  
Sangwook Park ◽  
...  
Keyword(s):  
Protein Aggregation ◽  
Dependent Manner ◽  
Cytosolic Protein

A novel P159L mutation in the Parkin gene related to autosomal dominantly inherited late onset parkinsonism and protein aggregation

2004 ◽  
Vol 31 (S 1) ◽  
Author(s):  
R Krüger ◽  
FP Marx ◽  
D Berg ◽  
C Holzmann ◽  
T Müller ◽  
...  
Keyword(s):  
Protein Aggregation ◽  
Late Onset ◽  
Parkin Gene

Diminished specific activity of cytosolic protein kinase C in sciatic nerve of streptozocin-induced diabetic rats and its correction by dietary myo-inositol

Diabetes ◽  
1991 ◽  
Vol 40 (11) ◽  
pp. 1545-1554 ◽  
Author(s):  
J. Kim ◽  
E. H. Rushovich ◽  
T. P. Thomas ◽  
T. Ueda ◽  
B. W. Agranoff ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Sciatic Nerve ◽  
Specific Activity ◽  
Diabetic Rats ◽  
Cytosolic Protein ◽  
Kinase C
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