Increased ACTL6A Occupancy within mSWI/SNF Chromatin Remodelers Drives Human Squamous Cell Carcinoma

2021 ◽  
Author(s):  
Chiung-Ying Chang ◽  
Zohar Shipony ◽  
Ann Kuo ◽  
Kyle M. Loh ◽  
William J. Greenleaf ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Chromatin Remodelers ◽  
Human Squamous Cell Carcinoma

Characterization of the Eugenol Effects on the Bioenergetic Profile of SCC-4 Human Squamous Cell Carcinoma Cell Line

2018 ◽  
Vol 69 (9) ◽  
pp. 2567-2570 ◽  
Author(s):  
Oana M. Duicu ◽  
Ioana Z. Pavel ◽  
Florin Borcan ◽  
Danina M. Muntean ◽  
Adelina Cheveresan ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cell Line ◽  
Squamous Cell ◽  
Carcinoma Cell ◽  
Carcinoma Cell Line ◽  
Squamous Cell Carcinoma Cell ◽  
Human Squamous Cell Carcinoma ◽  
Extracellular Flux ◽  
Transport Chain

Eugenol (EU), the active ingredient in clove oil, is commonly used as successful therapeutic compound in dentistry due to its antiseptic and anti-inflammatory effects. Recent research studies suggest that eugenol has also a potential anti-cancer effect. This study was thereby purported to assess the effects of EU on the bioenergetic profile of the SCC-4 human squamous cell carcinoma cell line. To this aim, SCC-4 cells were treated for 24 hours with free EU and EU incorporated in polyurethane structures (50 �M each). Oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) were measured using the Seahorse XF-24e extracellular flux analyzer (Agilent Technologies Inc.). Analysis of the SCC-4 bioenergetic profile was performed in the presence of the classic modulators of the electron transport chain: oligomycin, FCCP, and antimycin A+rotenone. Our data showed that cells stimulated with free EU induced a decrease of OCR linked parameters and an increase of ECAR, effects that were abolished by the incorporation of EU in polyurethane structures. In conclusion, free eugenol elicits inhibitory effects on mitochondrial respiration in the SCC-4 cell line, a result that might be suggestive for its anti-tumoral effects.

Human Squamous Cell Carcinoma: Establishment and Characterization of New Permanent Cell Lines

1981 ◽  
Vol 107 (11) ◽  
pp. 703-710 ◽  
Author(s):  
C. J. Krause ◽  
T. E. Carey ◽  
R. W. Ott ◽  
C. Hurbis ◽  
K. D. McClatchey ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cell Lines ◽  
Squamous Cell ◽  
Human Squamous Cell Carcinoma ◽  
Permanent Cell

scholarly journals C/EBP Transcription Factors in Human Squamous Cell Carcinoma: Selective Changes in Expression of Isoforms Correlate with the Neoplastic State

PLoS ONE ◽  
2014 ◽  
Vol 9 (11) ◽  
pp. e112073 ◽  
Author(s):  
Sanjay Anand ◽  
John Ebner ◽  
Christine B. Warren ◽  
Manu S. Raam ◽  
Melissa Piliang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Transcription Factors ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Human Squamous Cell Carcinoma

Analysis of ras oncogene mutations in human squamous cell carcinoma of the head and neck

1992 ◽  
Vol 1 (6) ◽  
pp. 405-411 ◽  
Author(s):  
F. Nuñez ◽  
O. Dominguez ◽  
E. Coto ◽  
C. Suarez-Nieto ◽  
P. Perez ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Ras Oncogene ◽  
Human Squamous Cell Carcinoma

Synthesis of Parathyroid Hormone-Like Peptides by a Human Squamous Cell Carcinoma

1977 ◽  
Vol 45 (5) ◽  
pp. 1023-1030 ◽  
Author(s):  
JAMES W. HAMILTON ◽  
CHARLES R. HARTMAN ◽  
DOUGLAS H. MCGREGOR ◽  
DAVID V. COHN
Keyword(s):  
Squamous Cell Carcinoma ◽  
Parathyroid Hormone ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Human Squamous Cell Carcinoma
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