CD4 T Cell Help Prevents CD8 T Cell Exhaustion and Promotes Control of  Mycobacterium tuberculosis Infection

2021 ◽  
Author(s):  
Yu-Jung Wu ◽  
Palmira Barreira-Silva ◽  
Shayla Boyce ◽  
Jennifer Powers ◽  
Cavallo Kelly ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
T Cell ◽  
Cd8 T Cell ◽  
Cd4 T Cell ◽  
T Cell Exhaustion ◽  
Cell Exhaustion ◽  
Cd4 T Cell Help ◽  
T Cell Help

scholarly journals CD4 T cell help prevents CD8 T cell exhaustion and promotes control of Mycobacterium tuberculosis infection

Cell Reports ◽  
2021 ◽  
Vol 36 (11) ◽  
pp. 109696
Author(s):  
Yu-Jung Lu ◽  
Palmira Barreira-Silva ◽  
Shayla Boyce ◽  
Jennifer Powers ◽  
Kelly Cavallo ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
T Cell ◽  
Cd8 T Cell ◽  
Tuberculosis Infection ◽  
Cd4 T Cell ◽  
T Cell Exhaustion ◽  
Mycobacterium Tuberculosis Infection ◽  
Cell Exhaustion ◽  
Cd4 T Cell Help ◽  
T Cell Help

scholarly journals CD4 T cell help prevents CD8 T cell exhaustion and promotes control of Mycobacterium tuberculosis infection

2021 ◽  
Author(s):  
Yu-Jung Lu ◽  
Palmira Barreira-Silva ◽  
Shayla Boyce ◽  
Jennifer Powers ◽  
Kelly Cavallo ◽  
...  
Keyword(s):  
T Cells ◽  
Mycobacterium Tuberculosis ◽  
T Cell ◽  
Cd8 T Cells ◽  
Cd8 T Cell ◽  
Cd4 T Cell ◽  
Cell Responses ◽  
Cd4 T Cell Help ◽  
T Cell Help

SummaryCD4 T cells are essential for immunity to tuberculosis because they produce cytokines including interferon-γ. Whether CD4 T cells act as “helper” cells to promote optimal CD8 T cell responses during Mycobacterium tuberculosis is unknown. Using two independent models, we show that CD4 T cell help enhances CD8 effector functions and prevents CD8 T cell exhaustion. We demonstrate synergy between CD4 and CD8 T cells in promoting the survival of infected mice. Purified helped, but not helpless, CD8 T cells efficiently restrict intracellular bacterial growth in vitro. Thus, CD4 T cell help plays an essential role in generating protective CD8 T cell responses against M. tuberculosis infection in vitro and in vivo. We infer vaccines that elicit both CD4 and CD8 T cells are more likely to be successful than vaccines that elicit only CD4 or CD8 T cells.

scholarly journals Early CD4+T Cell Help Prevents Partial CD8+T Cell Exhaustion and Promotes Maintenance of Herpes Simplex Virus 1 Latency

2009 ◽  
Vol 184 (1) ◽  
pp. 277-286 ◽  
Author(s):  
Gregory M. Frank ◽  
Andrew J. Lepisto ◽  
Michael L. Freeman ◽  
Brian S. Sheridan ◽  
Thomas L. Cherpes ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
T Cell ◽  
Cd8 T Cell ◽  
Cd4 T Cell ◽  
T Cell Exhaustion ◽  
Herpes Simplex Virus 1 ◽  
Cell Exhaustion ◽  
Simplex Virus ◽  
T Cell Help

CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death

Nature ◽  
2005 ◽  
Vol 434 (7029) ◽  
pp. 88-93 ◽  
Author(s):  
Edith M. Janssen ◽  
Nathalie M. Droin ◽  
Edward E. Lemmens ◽  
Michael J. Pinkoski ◽  
Steven J. Bensinger ◽  
...  
Keyword(s):  
Cell Death ◽  
T Cell ◽  
Cd8 T Cell ◽  
Cd4 T Cell ◽  
T Cell Memory ◽  
Cell Memory ◽  
Activation Induced Cell Death ◽  
Cd4 T Cell Help ◽  
Cd8 T Cell Memory ◽  
T Cell Help

scholarly journals IL-2 Mediates CD4+ T Cell Help in the Breakdown of Memory-Like CD8+ T Cell Tolerance under Lymphopenic Conditions

PLoS ONE ◽  
2010 ◽  
Vol 5 (9) ◽  
pp. e12659 ◽  
Author(s):  
Cécile Le Saout ◽  
Marine Villard ◽  
Clémence Cabasse ◽  
Chantal Jacquet ◽  
Naomi Taylor ◽  
...  
Keyword(s):  
T Cell ◽  
Cd8 T Cell ◽  
Cd4 T Cell ◽  
T Cell Tolerance ◽  
Cell Tolerance ◽  
Cd4 T Cell Help ◽  
T Cell Help

scholarly journals Requirement for CD4 T Cell Help in Maintenance of Memory CD8 T Cell Responses Is Epitope Dependent

2007 ◽  
Vol 178 (10) ◽  
pp. 6350-6358 ◽  
Author(s):  
Elizabeth A. Ramsburg ◽  
Jean M. Publicover ◽  
Dagan Coppock ◽  
John K. Rose
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Cd4 T Cell ◽  
Cell Responses ◽  
Cd4 T Cell Help ◽  
Memory Cd8 T Cell ◽  
T Cell Help
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