Gene-Based Diagnosis of Tuberculosis from Oral Swabs with a New Generation Pathogen Enrichment Technique in Real-World Practice

2021 ◽  
Author(s):  
Young Ae Kang ◽  
Bonhan Koo ◽  
Ock-Hwa Kim ◽  
Joung Ha Park ◽  
Ho Cheol Kim ◽  
...  
Keyword(s):  
Real World ◽  
Enrichment Technique ◽  
New Generation

scholarly journals Analyzing and Estimating the Performance of Concurrent Kernels Execution on GPUs

2017 ◽  
Author(s):  
Rommel Cruz ◽  
Lucia Drummond ◽  
Esteban Clua ◽  
Cristiana Bentes
Keyword(s):  
Resource Utilization ◽  
Real World ◽  
Power Efficiency ◽  
Necessary Conditions ◽  
Performance Degradation ◽  
Computing Power ◽  
Concurrent Execution ◽  
Depth Study ◽  
New Generation

GPUs have established a new baseline for power efficiency and computing power, delivering larger bandwidth and more computing units in each new generation. Modern GPUs support the concurrent execution of kernels to maximize resource utilization, allowing other kernels to better exploit idle resources. However, the decision on the simultaneous execution of different kernels is made by the hardware, and sometimes GPUs do not allow the execution of blocks from other kernels, even with the availability of resources. In this work, we present an in-depth study on the simultaneous execution of kernels on the GPU. We present the necessary conditions for executing kernels simultaneously, we define the factors that influence competition, and describe a model that can determine performance degradation. Finally, we validate the model using synthetic and real-world kernels with different computation and memory requirements.

Coronary artery bypass confers intermediate-term survival benefit over percutaneous coronary intervention with new-generation stents in real-world patients with multivessel coronary artery disease, including left main disease: a retrospective analysis of 6383 patients

2019 ◽  
Vol 56 (5) ◽  
pp. 911-918 ◽  
Author(s):  
Vasileios F Panoulas ◽  
Charles J Ilsley ◽  
Konstantinos Kalogeras ◽  
Habib Khan ◽  
Maria Monteagudo Vela ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Real World ◽  
Artery Bypass ◽  
Coronary Intervention ◽  
Drug Eluting Stents ◽  
Term Survival ◽  
Percutaneous Coronary ◽  
All Cause Mortality ◽  
Drug Eluting ◽  
New Generation

Abstract OBJECTIVES The intermediate-term all-cause mortality rate of real-world patients with multivessel disease (MVD) treated with percutaneous coronary intervention (PCI) with new-generation drug-eluting stents or coronary artery bypass grafting (CABG) remains unknown. We sought to compare the intermediate-term all-cause mortality rates of real-world patients with MVD including left main stem disease, treated with CABG or PCI. METHODS All consecutive all-comer patients with MVD undergoing CABG or PCI with second/third generation drug-eluting stents from 2007 to 2015 in Harefield Hospital, UK were included in this study. The revascularization modality was based on heart team discussions. Primary outcome was all-cause mortality. Mean follow-up of the study was 3.3 years. Cox regression analysis and propensity matching were used. RESULTS Of 6383 patients with MVD, 4230 underwent CABG, whereas 2153 had PCI with new-generation stents. In the CABG group, the mean age was 66.4 ± 10 years, whereas in the PCI group it was 65.3 ± 12.1 years (P < 0.001). Fewer female patients with MVD were treated with CABG than were treated with PCI (18.5% vs 20.5%; P = 0.026). There was a higher 5-year estimated survival rate among patients having CABG (88% vs 78.3%; Plog-rank < 0.001). The adjusted hazard ratio (HR) for PCI over CABG was 1.74 [95% confidence interval (CI) 1.41–2.16; P < 0.001]. A total of 653 patients having CABG and 653 having PCI were included in the propensity-matched groups. At mean follow-up, PCI was associated with a higher adjusted HR for all-cause mortality (2.18, 95% CI 1.54–3.1; P < 0.001). CONCLUSIONS In this contemporary cohort of real-world patients with MVD, CABG was associated with increased intermediate-term survival compared to PCI with new-generation drug-eluting stents.

scholarly journals The denial of limits and interior aspects of descent

foresight ◽  
2014 ◽  
Vol 16 (6) ◽  
pp. 527-549 ◽  
Author(s):  
Richard A. Slaughter
Keyword(s):  
Real World ◽  
Social Implications ◽  
It Infrastructure ◽  
Content Type ◽  
Limits To Growth ◽  
The Social ◽  
Economic Indices ◽  
New Generation ◽  
Start Ups ◽  
Practical Implications

Purpose – The purposes of this paper are as follows. Part one examines the role of denialism in the context of proposals advanced through the much-abused Limits to Growth (LtG) project. Part two uses three sets of criteria (domains of reality, worldviews and values) to characterise some of the interior human and social aspects of the “denial machine.” It uses these criteria to address some vital, but currently under-appreciated “interior” aspects of descent. (N.B. A succinct “primer” or overview of the concept and underpinning rationale for notions of “descent pathways” is provided in the introduction to this special issue.) Design/methodology/approach – The paper draws on a number of authoritative sources that track the dimensions of global change and, specifically, the ways that humanity is tracking towards Dystopian overshoot-and-collapse futures. The significance of the LtG project is assessed in this context. Part two employs the criteria noted above to identify and open out the centrality of the human and cultural interiors. Findings – Responses to the LtG project are shown to have deprived humanity of the clarity and will to respond effectively to the emerging global emergency. The rise of climate change denialism has followed suit and made effective responses increasingly difficult. A new focus, however, on some of the dynamics of reality domains, worldviews and values, clarifies both the nature of the problem and prefigures a range of solutions, some of which are briefly outlined. Research limitations/implications – This is primarily a conceptual paper that suggests a range of practical responses. For example, re-purposing parts of the current information technology (IT) infrastructure away from financial and economic indices to those tracking the health of the planet. Also translating the case put forward here for a new generation of Institutions of Foresight (IoFs) into real-world start-ups and examples. Further research is needed into the uses and limitations both of positive and negative views of futures. It is suggested that the latter have more value than is commonly realised. Practical implications – In addition to those stated above, the practical implications include new uses for IT infrastructure based on worldcentric – rather than financial and economic worldviews; designing and implementing a new generation of IoFs; and finding new ways to inform the public of impending Dystopian outcomes without exacerbating avoidance and depression. Social implications – The social implications are profound. Currently, humanity has allowed itself to “tune out” and ignore many of the well-founded “signals” (from the global system) and warnings (from those who have observed and tracked real-world changes). As a result, it has outgrown the capacity of the planet to support the current population, let alone the 10 billion currently projected by the United Nations (UN). Something must give. Applied foresight can provide essential lead time to act before human actions are overwhelmed by forces beyond its control. Originality/value – The paper draws together material from hitherto disparate sources to assess the LtG project. It also deploys key concepts from an integral perspective that shed new light on human and cultural forces that determine how people respond to the prospect of Dystopian futures. In so doing, it provides insight into why we are where we are and also into some of the means by which humanity can respond. Specifically, it suggests a shift from collapse narratives to those of descent.

scholarly journals Autofiction and the Diary: The Radicalization of Autofiction in Works by Hervé Guibert and Christine Angot

2022 ◽  
pp. 267-285
Author(s):  
Sam Ferguson
Keyword(s):  
Real World ◽  
Experimental Writing ◽  
The Novel ◽  
The Real ◽  
New Generation ◽  
Herve Guibert

AbstractAutofiction has often been viewed as a hybrid of autobiography and the novel. This chapter argues that a new generation of writers who emerged from the 1990s onward drew heavily on the diary instead of autobiography to develop their own innovative autofictional forms and practices. Whereas some critics have argued that the diary is fundamentally attached to truth and resistant to fiction, Hervé Guibert’s Voyage avec deux enfants (“Journey with Two Children,” 1982) and Christine Angot’s Léonore, toujours (“Léonore, Always,” 1993) provide two examples of experimental writing projects where the diary provides the means for new modalities of truth and fiction, allowing the authors to adopt a new relation to their writing and the real world.

A novel tunable stiffness mechanism using filament jamming

2021 ◽  
pp. 1-11
Author(s):  
Junfeng Hu ◽  
Chengkun Xiao ◽  
Tao Wen
Keyword(s):  
Mechanical Behavior ◽  
Experimental Test ◽  
Real World ◽  
Dynamic Performance ◽  
Experimental Results ◽  
Important Method ◽  
High Stiffness ◽  
Stiffness Variation ◽  
New Generation ◽  
Tunable Stiffness

Abstract The jamming mechanism is an important method to tune the stiffness of soft-bodied machines to enable them to adapt to their surroundings. However, it is difficult for the present jamming structures to integrate them into complicated structures such as twist, cylinder, and spiral. This paper introduces a novel jamming mechanism termed a filament jamming technique, which varies stiffness using jamming of a cluster of tiny and compliant filaments. The jamming structure demonstrated a variety of characteristics such as softness, shape compatibility, lightweight, and high stiffness, which these feats can meet to a variety of application scenarios that the traditional jamming one cannot afford. The mechanical behavior of the jamming structure was studied with an experimental test, in which the experimental results illustrated that its structural and material factors affect stiffness variation and dynamic performance. To demonstrate the advantage of the jamming technique, we constructed a soft gripper and a torsional actuator to demonstrate how the mechanics of filament jamming can enhance the performance of real-world robotics systems. Therefore, the filament jamming mechanism provides a variety of machines and structures with additional properties to increase forces transmitted to the environment and to tune response and damping. This study aims to foster a new generation of mechanically versatile machines and structures with both softness and stiffness.

scholarly journals P5 The real world effectiveness of new generation spatz balloon on weight loss in super-obese patients

2021 ◽  
Author(s):  
Mohammed Khan ◽  
Adnan Al-Zanbagi ◽  
Abdulaziz Tashkandi ◽  
Ali Montashery ◽  
Abdulwahab Neyazi ◽  
...  
Keyword(s):  
Weight Loss ◽  
Real World ◽  
Obese Patients ◽  
Super Obese ◽  
The Real ◽  
New Generation
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