Stopping Oral Polio Vaccine (OPV) after Defeating Poliomyelitis: A Pyrrhic Victory? Systematic Review of the Non-Specific Effects of OPV

2021 ◽  
Author(s):  
Peter Aaby ◽  
Sebastian Nielsen ◽  
Ane Fisker ◽  
Line M. Pedersen ◽  
Paul Welaga ◽  
...  
Keyword(s):  
Systematic Review ◽  
Oral Polio Vaccine ◽  
Polio Vaccine ◽  
Specific Effects ◽  
Pyrrhic Victory

scholarly journals Oral Polio Vaccine Campaigns May Reduce the Risk of Death from Respiratory Infections

Vaccines ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1133
Author(s):  
Sebastian Nielsen ◽  
Hasan Mahmud Sujan ◽  
Christine Stabell Benn ◽  
Peter Aaby ◽  
Syed Manzoor Ahmed Hanifi
Keyword(s):  
Respiratory Infections ◽  
Oral Polio Vaccine ◽  
Surveillance Systems ◽  
Vitamin A Supplementation ◽  
Risk Of Death ◽  
Polio Vaccine ◽  
Specific Effects ◽  
National Campaigns ◽  
Demographic Surveillance Systems ◽  
Overall Mortality

Oral polio vaccine (OPV) campaigns, but not other campaigns, have been associated with major reductions in child mortality. Studies have shown that OPV reduces the risk of respiratory infections. We analysed the causes of death at 0–2 years of age in Chakaria, a health and demographic surveillance Systems in Bangladesh, in the period 2012–2019 where 13 national campaigns with combinations of OPV (n = 4), vitamin A supplementation (n = 9), measles vaccine (MV) (n = 2), and albendazole (n = 2) were implemented. OPV-only campaigns reduced overall mortality by 30% (95% confidence interval: −10–56%). Deaths from respiratory infections were reduced by 62% (20–82%, p = 0.01) in the post-neonatal period (1–35 months), whereas there was as slight increase of 19% (−37–127%, p = 0.54) for deaths from other causes. There was no benefit of other types of campaigns. Hence, the hypothesis that OPV may have beneficial non-specific effects, protecting particularly against respiratory infections, was confirmed.

Towards Polio Eradication in Nigeria: Identifying at Risk Population for Low Oral Polio Vaccine (OPV) Uptake

PEDIATRICS ◽  
2016 ◽  
Vol 137 (Supplement 3) ◽  
pp. 389A-389A
Author(s):  
Oluyemisi O. Falope ◽  
Korede K. Adegoke ◽  
Chukwudi O. Ejiofor ◽  
Nnadozie C. Emechebe ◽  
Taiwo O Talabi ◽  
...  
Keyword(s):  
At Risk ◽  
Oral Polio Vaccine ◽  
Polio Eradication ◽  
Risk Population ◽  
Polio Vaccine

scholarly journals The case for replacing live oral polio vaccine with inactivated vaccine in the Americas

The Lancet ◽  
2020 ◽  
Vol 395 (10230) ◽  
pp. 1163-1166
Author(s):  
Jorge A Alfaro-Murillo ◽  
Marí L Ávila-Agüero ◽  
Meagan C Fitzpatrick ◽  
Caroline J Crystal ◽  
Luiza-Helena Falleiros-Arlant ◽  
...  
Keyword(s):  
Oral Polio Vaccine ◽  
Inactivated Vaccine ◽  
Polio Vaccine

scholarly journals Inferring Numbers of Wild Poliovirus Excretors Using Quantitative Environmental Surveillance

Vaccines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 870
Author(s):  
Yuri Perepliotchikov ◽  
Tomer Ziv-Baran ◽  
Musa Hindiyeh ◽  
Yossi Manor ◽  
Danit Sofer ◽  
...  
Keyword(s):  
Oral Polio Vaccine ◽  
Turnaround Time ◽  
Quantitative Detection ◽  
Environmental Surveillance ◽  
Wild Poliovirus ◽  
Polio Vaccine ◽  
Kinetic Information ◽  
Using Data ◽  
Number Of Individuals

Response to and monitoring of viral outbreaks can be efficiently focused when rapid, quantitative, kinetic information provides the location and the number of infected individuals. Environmental surveillance traditionally provides information on location of populations with contagious, infected individuals since infectious poliovirus is excreted whether infections are asymptomatic or symptomatic. Here, we describe development of rapid (1 week turnaround time, TAT), quantitative RT-PCR of poliovirus RNA extracted directly from concentrated environmental surveillance samples to infer the number of infected individuals excreting poliovirus. The quantitation method was validated using data from vaccination with bivalent oral polio vaccine (bOPV). The method was then applied to infer the weekly number of excreters in a large, sustained, asymptomatic outbreak of wild type 1 poliovirus in Israel (2013) in a population where >90% of the individuals received three doses of inactivated polio vaccine (IPV). Evidence-based intervention strategies were based on the short TAT for direct quantitative detection. Furthermore, a TAT shorter than the duration of poliovirus excretion allowed resampling of infected individuals. Finally, the method documented absence of infections after successful intervention of the asymptomatic outbreak. The methodologies described here can be applied to outbreaks of other excreted viruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), where there are (1) significant numbers of asymptomatic infections; (2) long incubation times during which infectious virus is excreted; and (3) limited resources, facilities, and manpower that restrict the number of individuals who can be tested and re-tested.

scholarly journals Oral Polio Vaccine Influences the Immune Response to BCG Vaccination. A Natural Experiment

PLoS ONE ◽  
2010 ◽  
Vol 5 (5) ◽  
pp. e10328 ◽  
Author(s):  
Erliyani Sartono ◽  
Ida M. Lisse ◽  
Elisabeth M. Terveer ◽  
Paula J. M. van de Sande ◽  
Hilton Whittle ◽  
...  
Keyword(s):  
Immune Response ◽  
Natural Experiment ◽  
Oral Polio Vaccine ◽  
Bcg Vaccination ◽  
Polio Vaccine

scholarly journals Excretion of Wild-Type and Vaccine-Derived Poliovirus in the Feces of Poliovirus Receptor-Transgenic Mice

2003 ◽  
Vol 77 (11) ◽  
pp. 6541-6545 ◽  
Author(s):  
Hein J. Boot ◽  
Daniella T. J. Kasteel ◽  
Anne-Marie Buisman ◽  
Tjeerd G. Kimman
Keyword(s):  
Transgenic Mice ◽  
Oral Polio Vaccine ◽  
Fecal Excretion ◽  
Wild Type ◽  
Genetic Determinants ◽  
Poliovirus Type ◽  
Oral Transmission ◽  
Polio Vaccine ◽  
Poliovirus Receptor

ABSTRACT The emergence of circulating vaccine-derived poliovirus (cVDPV) strains in suboptimally vaccinated populations is a serious threat to the global poliovirus eradication. The genetic determinants for the transmissibility phenotype of polioviruses, and in particularly of cVDPV strains, are currently unknown. Here we describe the fecal excretion of wild-type poliovirus, oral polio vaccine, and cVDPV (Hispaniola) strains after intraperitoneal injection in poliovirus receptor-transgenic mice. Both the pattern and the level of fecal excretion of the cVDPV strains resemble those of wild-type poliovirus type 1. In contrast, very little poliovirus was present in the feces after oral polio vaccine administration. This mouse model will be helpful in elucidating the genetic determinants for the high fecal-oral transmission phenotype of cVDPV strains.

scholarly journals Evaluating cessation of the type 2 oral polio vaccine by modeling pre- and post-cessation detection rates

Vaccine ◽  
2017 ◽  
Vol 35 (42) ◽  
pp. 5674-5681 ◽  
Author(s):  
Steve J. Kroiss ◽  
Michael Famulare ◽  
Hil Lyons ◽  
Kevin A. McCarthy ◽  
Laina D. Mercer ◽  
...  
Keyword(s):  
Oral Polio Vaccine ◽  
Detection Rates ◽  
Polio Vaccine

scholarly journals Sex-Differential Effect on Infant Mortality of Oral Polio Vaccine Administered with BCG at Birth in Guinea-Bissau. A Natural Experiment

PLoS ONE ◽  
2008 ◽  
Vol 3 (12) ◽  
pp. e4056 ◽  
Author(s):  
Christine Stabell Benn ◽  
Ane Bærent Fisker ◽  
Amabelia Rodrigues ◽  
Henrik Ravn ◽  
Erliyani Sartono ◽  
...  
Keyword(s):  
Infant Mortality ◽  
Differential Effect ◽  
Natural Experiment ◽  
Oral Polio Vaccine ◽  
Polio Vaccine ◽  
Guinea Bissau
Sign in / Sign up

Export Citation Format

Share Document