Is WGS Appropriate for SARS-CoV-2 Epidemiological Studies in Low- and Middle-Income Countries? An Epidemiologic Study of D614G Mutation Using a Rapid Low-Cost Method in Quito-Ecuador

2021 ◽  
Author(s):  
Paula Leoro-Garzón ◽  
Galo Leoro-Monroy ◽  
David Ortega-Paredes ◽  
Gabriel Molina-Cuasapaz ◽  
Pablo González-Andrade ◽  
...  
Keyword(s):  
Low Cost ◽  
Epidemiologic Study ◽  
Epidemiological Studies ◽  
Middle Income ◽  
Middle Income Countries ◽  
Low And Middle Income

scholarly journals Barriers to training in laparoscopic surgery in low- and middle-income countries: A systematic review

2021 ◽  
pp. 004947552199818
Author(s):  
Ellen Wilkinson ◽  
Noel Aruparayil ◽  
J Gnanaraj ◽  
Julia Brown ◽  
David Jayne
Keyword(s):  
Laparoscopic Surgery ◽  
Low Cost ◽  
Surgical Care ◽  
Successful Implementation ◽  
Middle Income ◽  
Middle Income Countries ◽  
Technological Advances ◽  
Local Access ◽  
And Training ◽  
Low And Middle Income

Laparoscopic surgery has the potential to improve care in resource-deprived low- and-middle-income countries (LMICs). This study aims to analyse the barriers to training in laparoscopic surgery in LMICs. Medline, Embase, Global Health and Web of Science were searched using ‘LMIC’, ‘Laparoscopy’ and ‘Training’. Two researchers screened results with mutual agreement. Included papers were in English, focused on abdominal laparoscopy and training in LMICs. PRISMA guidelines were followed; 2992 records were screened, and 86 full-text articles reviewed to give 26 key papers. Thematic grouping identified seven key barriers: funding; availability and maintenance of equipment; local access to experienced laparoscopic trainers; stakeholder dynamics; lack of knowledge on effective training curricula; surgical departmental structure and practical opportunities for trainees. In low-resource settings, technological advances may offer low-cost solutions in the successful implementation of laparoscopic training and improve access to surgical care.

scholarly journals Alzheimer’s Disease Diagnostics Must Be Globally Accessible

2021 ◽  
pp. 1-3
Author(s):  
Nicholas Clute-Reinig ◽  
Suman Jayadev ◽  
Kristoffer Rhoads ◽  
Anne-Laure Le Ny
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Global Health ◽  
Low Cost ◽  
High Income ◽  
Middle Income ◽  
Middle Income Countries ◽  
Disease Diagnostics ◽  
Low And Middle Income

Dementia and Alzheimer’s disease (AD) are global health crises, with most affected individuals living in low- or middle-income countries. While research into diagnostics and therapeutics remains focused exclusively on high-income populations, recent technological breakthroughs suggest that low-cost AD diagnostics may soon be possible. However, as this disease shifts onto those with the least financial and structural ability to shoulder its burden, it is incumbent on high-income countries to develop accessible AD healthcare. We argue that there is a scientific and ethical mandate to develop low-cost diagnostics that will not only benefit patients in low-and middle-income countries but the AD field as a whole.

Low-Cost Bubble-CPAP Treatment of a Severe Case of Pneumonia in a Low- and Middle-Income Country: A Case Report on the Importance of Optimizing Bubble-CPAP Setup

2020 ◽  
Author(s):  
Søren Vinther Larsen ◽  
Anja Poulsen
Keyword(s):  
Low Cost ◽  
Severe Case ◽  
Middle Income ◽  
Healthcare Facilities ◽  
Middle Income Countries ◽  
Efficient Delivery ◽  
Bubble Cpap ◽  
Two Parameters ◽  
Lower Respiratory Disease ◽  
Low And Middle Income

Abstract A homemade low-cost bubble continuous positive airway pressure (bCPAP) setup can be created using resources available at most secondary healthcare facilities in low- and middle-income countries (LMICs). This setup has the potential of saving millions of children’s lives worldwide; however, treatment failure due to bCPAP setup insufficiencies and lack of educated staff remains a significant obstacle. Here, we report a first-hand experience on the use of an established low-cost bCPAP setup to be used in LMICs and how optimization of two parameters was critical to effectively treat a severe case of lower respiratory disease in a 6-month-old infant in Tanzania. We report this case to strengthen that reducing the resistance in the tube system and minimizing air leakage at the nasal interface are crucial for efficient delivery of the CPAP therapy.

scholarly journals A Bibliometric Analysis of Published Literature in Postoperative Pain in Elderly Patients in Low- and Middle-Income Countries

2021 ◽  
Vol 10 (11) ◽  
pp. 2334
Author(s):  
João Batista Santos Garcia ◽  
Érica Brandão de Moraes ◽  
José Osvaldo Barbosa Neto
Keyword(s):  
Postoperative Pain ◽  
Elderly Patients ◽  
Bibliometric Analysis ◽  
Low Income ◽  
The Elderly ◽  
Epidemiological Studies ◽  
Middle Income ◽  
Middle Income Countries ◽  
Citation Indexes ◽  
Low And Middle Income

Postoperative pain (POP) remains a major challenge for surgeons and anesthesiologists worldwide, especially in low- and middle-income countries. Elderly patients are at higher risk for undertreatment of pain. Despite that, there is a paucity of papers addressing POP among this population in developing countries. This study aimed to provide a bibliometric analysis of the literature concerning postoperative pain in elderly patients from low- and middle-income countries. It was performed an extensive search of papers on this subject through the Web of Science and Scopus database using a series of uniterms and, including publications from 2001 to 2021. Publication quality was assessed by using total citation frequency, average citations per item and other citation indexes. Citation indexes were low, with the highest reaching 15 citations. In conclusion, few studies of postoperative pain in the elderly in countries with medium and low income, indicating a need that has not yet been met for this population and in these areas of the world. The published studies were not specifically aimed at the elderly, had limited impact, low international visibility. They were not epidemiological studies and are not robust, weakening knowledge and decision-making towards policies directed at this vulnerable population.

Development of a paper-immobilized yeast biosensor for the detection of physiological concentrations of doxycycline in technology-limited settings

2020 ◽  
Vol 12 (16) ◽  
pp. 2123-2132 ◽  
Author(s):  
Rachel A. Miller ◽  
Galen Brown ◽  
Elsa Barron ◽  
Jamie L. Luther ◽  
Marya Lieberman ◽  
...  
Keyword(s):  
Low Cost ◽  
Dosage Forms ◽  
Middle Income ◽  
Immobilized Yeast ◽  
Middle Income Countries ◽  
Low And Middle Income

To combat pharmaceutical counterfeiting in low- and middle-income countries (LMIC), there is a need for improved low-cost, portable methods that monitor pharmaceutical concentrations relevant to dosage forms and physiological fluids.

scholarly journals Covid-19 Infection, Illness and Deaths Among Healthcare Workers in Low- and Middle-Income Countries: A Systematic Review Protocol

2021 ◽  
Author(s):  
Moses Ocan ◽  
Brenda Allen Kawala ◽  
Ephraim Kisangala ◽  
Regina Ndagire ◽  
Rachel Nante Wangi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Healthcare Workers ◽  
Low Cost ◽  
Evidence Synthesis ◽  
Cochrane Library ◽  
Middle Income ◽  
Middle Income Countries ◽  
Mesh Terms ◽  
The Impact ◽  
Low And Middle Income

Abstract Background: Globally, health care workers continue to be infected, fall ill and die at the frontline of the Coronavirus disease 2019 (COVID-19) fight, an indicator of inadequate safety in health facilities. This rapid evidence synthesis aims to highlight the impacts of COVID-19 on healthcare workers in low-and middle-income countries (LMICs) in terms of infections, illnesses and deaths. Methods: A systematic review will be done. Article search will be performed by an experienced librarian in PubMed, MEDLINE Ovid, Google Scholar, COVID-END, Cochrane library and targeted search from other relevant sources. MeSH terms and Boolean operators “AND” and “OR” will be used in the article search. Independent reviewers will screen the retrieved articles using a priori criteria. Data abstraction will be done using an excel based abstraction tool and synthesized using structured narratives and summary of findings tables. Discussion and anticipated use of results: This evidence synthesis seeks to analyze the impact of COVID-19 on the healthcare systems of low- and middle-income countries. Information on healthcare worker infections, illness, and deaths due to COVID-19, will be collated from published research articles. This will help guide decision makers in establishing low- cost high impact interventions to mitigate the effects of COVID-19 in the health work force.Protocol registration: PROSPERO CRD 42020204174

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