scholarly journals Global Impact and Cost-Effectiveness of One-Dose Versus Two-Dose Human Papillomavirus Vaccination Schedules: A Comparative Modelling Analysis

2021 ◽  
Author(s):  
Kiesha Prem ◽  
Yoon Hong Choi ◽  
Élodie Bénard ◽  
Emily A. Burger ◽  
Liza Hadley ◽  
...  
Vaccine ◽  
2011 ◽  
Vol 29 (48) ◽  
pp. 8929-8936 ◽  
Author(s):  
Johannes A. Bogaards ◽  
Veerle M.H. Coupé ◽  
Chris J.L.M. Meijer ◽  
Johannes Berkhof

2010 ◽  
Vol 46 (16) ◽  
pp. 2973-2985 ◽  
Author(s):  
Mireia Diaz ◽  
Silvia de Sanjose ◽  
Jesse Ortendahl ◽  
Meredith O’Shea ◽  
Sue J. Goldie ◽  
...  

2021 ◽  
Vol 30 (6) ◽  
pp. 1283-1283
Author(s):  
Allison Portnoy ◽  
Nicole G. Campos ◽  
Stephen Sy ◽  
Emily A. Burger ◽  
Jamie Cohen ◽  
...  

Sexual Health ◽  
2015 ◽  
Vol 12 (6) ◽  
pp. 520 ◽  
Author(s):  
Luke B. Connelly ◽  
Ha N. D. Le

Background Human papillomavirus (HPV) vaccines and their widespread adoption have the potential to relieve a large part of the burden of cervical cancer morbidity and mortality, particularly in countries that have low screening rates or, like Japan, lack a cohesive universal screening program. An economic evaluation was conducted to assess the cost-effectiveness of introducing a bivalent HPV vaccination program in Japan from a healthcare perspective. Methods: A Markov model of the natural history of HPV infection that incorporates both vaccination and screening was developed for Japan. The modelled intervention, a bivalent HPV vaccine with a 100% lifetime vaccine efficacy and 80% vaccine coverage, given to a cohort of 12-year-old Japanese girls in conjunction with the current screening program, was compared with screening alone in terms of costs and effectiveness. A discount rate of 5% was applied to both costs and utilities where relevant. Results: Vaccination alongside screening compared with screening alone is associated with an incremental cost-effectiveness ratio (ICER) of US$20 315 per quality-adjusted-life-year gained if 80% coverage is assumed. The ICER at 5% coverage with the vaccine plus screening, compared with screening alone, is US$1158. Conclusion: The cost-effectiveness results suggest that the addition of a HPV vaccination program to Japan’s cervical cancer screening program is highly likely to prove a cost-effective way to reduce the burden of cervical cancer, precancerous lesions and HPV16/18-related diseases.


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