Reversal of SARS-CoV-2 Induced Hypoxia by Nebulized Sodium-Ibuprofen

2021 ◽  
Author(s):  
Oscar Salva ◽  
Pablo A. Doreski ◽  
Celia Sara Giler ◽  
Dario Conrado Quinodoz ◽  
Lucia Guadalupe Guzman ◽  
...  
Keyword(s):  
Sodium Ibuprofen

Assessment of Antithrombotic Properties of Sodium Ibuprofen

1982 ◽  
Vol 48 (01) ◽  
pp. 087-090 ◽  
Author(s):  
Carlos O Esquivel ◽  
David Bergqvist ◽  
Claes-Göran Björck ◽  
Stan N Carson ◽  
Bodil Nilsson
Keyword(s):  
Drug Administration ◽  
Platelet Function ◽  
Ex Vivo ◽  
Inhibitory Effect ◽  
Formation Time ◽  
Platelet Activity ◽  
Laser Injury ◽  
Sodium Ibuprofen ◽  
Plug Formation

SummaryThe effect of sodium ibuprofen on platelet activity in vivo and the lysability of ex vivo thrombi was investigated. The formation of a hemostatic platelet plug in the rabbit mesentery and platelet embolism as a response to a laser-induced injury in the ear chamber of rabbits were used as models for determining platelet activity. Ibuprofen at a dose of 25 mg/kg i.v. was found to increase the primary (PHT) and the total hemostatic plug formation time (THT). The same dose decreased the number of cumulative emboli over a 10 min period after a laser injury to arterioles. A dose of 10 mg/kg i.v. did not affect the formation of the hemostatic platelet plug. In dogs, doses of 10, 25 und 50 mg/kg did not enhance the release of 125I-FDP from the thrombi after incubation in plasmin, but the largest dose which is approximately five times the recommended dose in humans, did significantly decrease the thrombus weight 90 and 180 min after the drug administration. In conclusion, sodium ibuprofen was shown to have an inhibitory effect on platelet function in vivo and in large doses was also found to diminish the thrombus weight.

Response of human adenocarcinoma to chemotherapy: As sole agents and in combination with sodium ibuprofen

1984 ◽  
Vol 18 (2) ◽  
pp. 145-149 ◽  
Author(s):  
Joan A. Stratton ◽  
Patricia S. Braly ◽  
Philip J. DiSaia
Keyword(s):  
Sodium Ibuprofen

Sodium ibuprofen dihydrate and anhydrous

2012 ◽  
Vol 111 (3) ◽  
pp. 2009-2018 ◽  
Author(s):  
Roberta Censi ◽  
Valentina Martena ◽  
Ela Hoti ◽  
Ledjan Malaj ◽  
Piera Di Martino
Keyword(s):  
Sodium Ibuprofen

Teat tablet with sodium ibuprofen: the effect of sorbitol on therapeutic agent pharmaceutical availability and on physicochemical parameters of a drug form

Open Medicine ◽  
2009 ◽  
Vol 4 (1) ◽  
pp. 98-103
Author(s):  
Aneta Berner-Strzelczyk ◽  
Justyna Kołodziejska ◽  
Magdalena Piechota-Urbañska ◽  
Mariusz Piechota ◽  
Marian Zgoda
Keyword(s):  
Physicochemical Parameters ◽  
Smooth Surface ◽  
Therapeutic Agent ◽  
Inflammatory Activity ◽  
Drug Form ◽  
Disintegration Time ◽  
Percentage Content ◽  
Pharmaceutical Markets ◽  
Release Test ◽  
Sodium Ibuprofen

AbstractDosing pediatric drugs available on pharmaceutical markets of analgesic, antifebrile and anti-inflammatory activity to children up to 3 years of age is not precise and frequently causes problems. The aim of the study was to work out a pediatric teat form of a drug with sodium ibuprofen and to determine the effect of sorbitol content on pharmaceutical availability of the therapeutic agent. Three variants of tablets containing 50 mg of sodium ibuprofen differing in the percentage content of sorbitol (from 37% - batch I to 79% - batch III) were produced. Quality tests of the produced forms of drugs (PPVI) were performed and the tests of therapeutic agent pharmaceutical availability by spatula method and by a method with a teat. Tablets of all batches had a smooth surface and same shape. The content of the therapeutic agent was within the limit of 95-105% of the declared value. The highest value of Q coefficient in the release test by pharmacopeal method and the shortest disintegration time (12 minutes) were obtained for tablets with 79% content of sorbitol. In conclusion, teat tablets with sodium ibuprofen of the highest sorbitol content (79%) demonstrated the expected physicochemical parameters and high pharmaceutical availability.

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