Clinical Manifestations of Rift Valley Fever in Humans: Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Zacchaeus Anywaine ◽  
Swaib A. Lule ◽  
Christian Holm Hansen ◽  
George Warimwe ◽  
Alison Eliott
Keyword(s):  
Systematic Review ◽  
Rift Valley ◽  
Rift Valley Fever ◽  
Meta Analysis ◽  
Clinical Manifestations ◽  
Valley Fever

scholarly journals Safety and Efficacy Profile of Commercial Veterinary Vaccines against Rift Valley Fever: A Review Study

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Moataz Alhaj
Keyword(s):  
Rift Valley ◽  
Rift Valley Fever ◽  
Clinical Manifestations ◽  
Effective Vaccine ◽  
Published Data ◽  
Inactivated Vaccine ◽  
Significant Information ◽  
Valley Fever ◽  
Wide Range ◽  
Efficacy Profile

Rift Valley Fever (RVF) is an infectious illness with serious clinical manifestations and health consequences in humans as well as a wide range of domestic ruminants. This review provides significant information about the prevention options of RVF along with the safety-efficacy profile of commercial vaccines and some of RVF vaccination strategies. Information presented in this paper was obtained through a systematic investigation of published data about RVF vaccines. Like other viral diseases, the prevention of RVF relies heavily on immunization of susceptible herds with safe and cost-effective vaccine that is able to confer long-term protective immunity. Several strains of RVF vaccines have been developed and are available in commercial production including Formalin-Inactivated vaccine, live attenuated Smithburn vaccine, and the most recent Clone13. Although Formalin-Inactivated vaccine and live attenuated Smithburn vaccine are immunogenic and widely used in prevention programs, they proved to be accompanied by significant concerns. Despite Clone13 vaccine being suggested as safe in pregnant ewes and as highly immunogenic along with its potential for differentiating infected from vaccinated animals (DIVA), a recent study raised concerns about the safety of the vaccine during the first trimester of gestation. Accordingly, RVF vaccines that are currently available in the market to a significant extent do not fulfill the requirements of safety, potency, and DIVA. These adverse effects stressed the need for developing new vaccines with an excellent safety profile to bridge the gap in safety and immunity. Bringing RVF vaccine candidates to local markets besides the absence of validated serological test for DIVA remain the major challenges of RVF control.

scholarly journals A systematic review of Rift Valley Fever epidemiology 1931–2014

2015 ◽  
Vol 5 (1) ◽  
pp. 28024 ◽  
Author(s):  
Mark O. Nanyingi ◽  
Peninah Munyua ◽  
Stephen G. Kiama ◽  
Gerald M. Muchemi ◽  
Samuel M. Thumbi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Rift Valley ◽  
Rift Valley Fever ◽  
Valley Fever

scholarly journals TRANSFER OF DANGEROUS VIRAL INFECTIONS IN THE NON-ENDEMIC AREA

2017 ◽  
pp. 91-100
Author(s):  
V. A. Markin ◽  
D. E. Chifanov
Keyword(s):  
Rift Valley ◽  
Influenza A ◽  
Rift Valley Fever ◽  
Endemic Area ◽  
Viral Infections ◽  
Clinical Manifestations ◽  
Hemorrhagic Fever ◽  
Climatic Conditions ◽  
Valley Fever

Epidemic data are presented, possible causes analyzed and the dangers of observed in recent years expansion of existing areas of viral infections, including the introduction of the agent to the non-endemic area, evaluated. At the present time there is a significant expansion of the ranges of some zooantroponozes pathogens, particular filovirus Ebola and arboviruses - Rift Valley fever, Zika, Chikungunya. When extending the boundaries of epidemic foci in the new territory for the pathogen, can occur aggravating of clinical manifestations of the disease and increase mortality among the indigenous population. Extremely hazardous exotic viral hemorrhagic fever (Ebola, Marburg, Lassa) when transfer with sick people in some cases, can cause contamination of the contact persons. Rift Valley fever - one of the most aggressive arboviruses, in the case of importation can form stable epidemic foci. Transfer of Zika fever in the territory of the Russian Federation has not represent substantial epidemiological value. Epidemiological factors, essential for the formation of new areas of pathogens may include the presence of permissive candidates in natural hosts and vectors, the climatic conditions. Role of socio-economic factors is significant. Among of environmental factors is the important role of some trace elements, including selenium, involved in the regulation of homeostasis and which faults occur in the upward virulence virus mutating. In parts of Africa and Asia, with soils poor in selenium, were first introduced pathogens or highly virulent strains of influenza A, SARS, Ebola and of SIV, and drifts on these and similar areas have led to an increase in the virulence of viruses.

Complement fixation reaction of Rift Valley fever virus

1950 ◽  
Vol 5 (5) ◽  
pp. 243-247
Author(s):  
Minoru MATSUMOTO ◽  
Saburo IWASA ◽  
Motosige ENDO
Keyword(s):  
Rift Valley ◽  
Rift Valley Fever ◽  
Complement Fixation ◽  
Rift Valley Fever Virus ◽  
Fever Virus ◽  
Valley Fever ◽  
Fixation Reaction
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