Outcome of Debridement, Antibiotics and Implant Retention for Staphylococcal Hip and Knee Prosthetic Joint Infections, Focused on Rifampicin Use: A Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Henk Scheper ◽  
Maxime Gerritsen ◽  
Bart Pijls ◽  
Suzanne Van Asten ◽  
Leo Visser ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Joint Infections ◽  
Prosthetic Joint ◽  
Prosthetic Joint Infections ◽  
Implant Retention

scholarly journals Outcome of debridement, antibiotics and implant retention for staphylococcal hip and knee prosthetic joint infections, focused on rifampicin use: a systematic review and meta-analysis

2021 ◽  
Author(s):  
H Scheper ◽  
L M Gerritsen ◽  
B G Pijls ◽  
S A Van Asten ◽  
L G Visser ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Joint Infection ◽  
Success Rates ◽  
Joint Infections ◽  
Prosthetic Joint ◽  
Prosthetic Joint Infections ◽  
Implant Retention ◽  
Important Evidence

Abstract The treatment of staphylococcal prosthetic joint infection (PJI) with debridement, antibiotics and retention of the implant (DAIR) often results in failure. An important evidence gap concerns the treatment with rifampicin for PJI. A systematic review and meta-analysis were conducted to assess the outcome of staphylococcal hip and/or knee PJI after DAIR, focused on the role of rifampicin. Studies published until September 2nd, 2020 were included. Success rates were stratified for type of joint and type of micro-organism. Sixty-four studies were included. The pooled risk ratio for rifampicin effectiveness was 1.10 (95% CI 1.00-1.22). Pooled success rate was 69% for S. aureus hip PJI, 54% for S. aureus knee PJI, 83% for CNS hip PJI and 73% for CNS knee PJI. Success rates for MRSA PJI (58%) were similar to MSSA PJI (60%). The meta-analysis indicates that rifampicin may only prevent a small fraction of all treatment failures.

scholarly journals Antibiotic containing bone cement in prevention of hip and knee prosthetic joint infections: A systematic review and meta-analysis

2020 ◽  
Vol 23 ◽  
pp. 53-60 ◽  
Author(s):  
Sujeesh Sebastian ◽  
Yang Liu ◽  
Robin Christensen ◽  
Deepak Bushan Raina ◽  
Magnus Tägil ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bone Cement ◽  
Meta Analysis ◽  
Joint Infections ◽  
Prosthetic Joint ◽  
Prosthetic Joint Infections

Cefazolin and rifampin: A coagulopathy-inducing combination

2021 ◽  
Author(s):  
Natalia E Castillo Almeida ◽  
Ryan W Stevens ◽  
Pooja Gurram ◽  
Christina G Rivera ◽  
Gina A Suh
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Assessment Tool ◽  
International Normalized Ratio ◽  
Medication Therapy ◽  
Joint Infections ◽  
Prosthetic Joint ◽  
Prosthetic Joint Infections ◽  
Implant Retention ◽  
History Of

Abstract Purpose To identify risk factors that may predispose patients to rifampin- and cefazolin-induced coagulopathy. Summary An 86-year-old man with a history of rheumatoid arthritis on chronic prednisone and stage 3 chronic kidney disease, notably not on warfarin, presented to the hospital with a 10-day history of right hip pain, swelling, and drainage after a recent right total-hip arthroplasty. The patient underwent a combination of surgical intervention and medication therapy with rifampin and ceftriaxone. After discharge and at postoperative day 9, ceftriaxone was changed to cefazolin due to increasing alkaline phosphatase levels. Four weeks after the initial debridement, antibiotics, and implant retention, the patient underwent a second irrigation and debridement due to persistent infection. Cefazolin and rifampin therapy was extended. Three days later, the patient presented to the emergency room with significant bleeding at the surgical site and a profoundly elevated prothrombin time and international normalized ratio (INR). No potential contributors were identified. The Naranjo adverse drug reaction probability scale identified cefazolin and rifampin as the probable cause of elevated INR. The Liverpool adverse drug reaction avoidability assessment tool classified this adverse event as “definitely avoidable.” Conclusion Rifampin-containing regimens are often recommended to treat staphylococcal prosthetic joint infections when the implant is retained. In methicillin-susceptible staphylococcal infections, cefazolin is routinely employed as the β-lactam backbone of definitive antimicrobial regimens. Although rifampin- and cefazolin-induced hypoprothrombinemia seems to be rare, adverse consequences of its occurrence may be prevented with appropriate monitoring.

Prosthetic Joint Infections Caused by Candida Species: A Systematic Review and a Case Series

2018 ◽  
Vol 184 (1) ◽  
pp. 23-33 ◽  
Author(s):  
Yoo Ra Lee ◽  
Hyun Jung Kim ◽  
Eun Ju Lee ◽  
Jang Wook Sohn ◽  
Min Ja Kim ◽  
...  
Keyword(s):  
Systematic Review ◽  
Candida Species ◽  
Case Series ◽  
Joint Infections ◽  
Prosthetic Joint ◽  
Prosthetic Joint Infections

scholarly journals KLIC-score for predicting early failure in prosthetic joint infections treated with debridement, implant retention and antibiotics

2015 ◽  
Vol 21 (8) ◽  
pp. 786.e9-786.e17 ◽  
Author(s):  
E. Tornero ◽  
L. Morata ◽  
J.C. Martínez-Pastor ◽  
G. Bori ◽  
C. Climent ◽  
...  
Keyword(s):  
Early Failure ◽  
Joint Infections ◽  
Prosthetic Joint ◽  
Prosthetic Joint Infections ◽  
Implant Retention
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