A Prospective Study into COVID-19 Like Symptoms in Patients with and Without Immune Mediated Inflammatory Diseases or Immunomodulating Drugs

2021 ◽  
Author(s):  
Lotte van Ouwerkerk ◽  
Andrea E. van der Meulen ◽  
Maarten K. Ninaber ◽  
Onno YK Teng ◽  
Tom W.J. Huizinga ◽  
...  
Keyword(s):  
Prospective Study ◽  
Inflammatory Diseases ◽  
Immune Mediated ◽  
A Prospective Study ◽  
Immunomodulating Drugs

scholarly journals Prospective study into COVID-19-like symptoms in patients with and without immune-mediated inflammatory diseases or immunomodulating drugs

2021 ◽  
pp. annrheumdis-2021-219958
Author(s):  
Lotte van Ouwerkerk ◽  
Andrea E van der Meulen-de Jong ◽  
Maarten K Ninaber ◽  
Y K Onno Teng ◽  
Tom WJ Huizinga ◽  
...  
Keyword(s):  
Prospective Study ◽  
Inflammatory Diseases ◽  
Immune Mediated ◽  
Immunomodulating Drugs

scholarly journals Fecal calprotectin as a predictor of gastrointestinal immune-related adverse events (CF-19): A prospective study.

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 534
Author(s):  
Ana Cardeña Gutiérrez ◽  
Xabier Mielgo Rubio ◽  
Manuel Ruiz Muñoz ◽  
Ruth Martinez Cabañes ◽  
Diana Moreno Muñoz ◽  
...  
Keyword(s):  
Prospective Study ◽  
Roc Curve ◽  
Inflammatory Diseases ◽  
Fecal Calprotectin ◽  
Predictive Values ◽  
Immune Mediated ◽  
Contradictory Evidence ◽  
Sensitivity Specificity ◽  
A Prospective Study

Background: Colitis is a frequent immune-related toxicity, without any biomarker that may predict its onset. It is endoscopically similar to intestinal inflammatory diseases, where fecal calprotectin (FC) is used as a biomarker to early-detect a relapse. We found contradictory evidence about FC and immunotherapy and no prospective study was already published.   Methods: We present an analytical, observational and prospective study of one year’s duration. We analyzed FC basal, and then prior to each cycle until the sixth, ending with quarterly follow-up. For evaluating the predictive value of FC we estimated the area under the ROC curve for basal absolute values and for each cycle, and calculated its relative percentage change with respect to basal. We also planned to estimate sensitivity, specificity and predictive values indexes for different cut-off points. Because of lack of recruitment we did a preliminary analysis at the end of the initially estimated period before suggesting its prolongation.   Results: 24 patients (19 male) were included in the study. This included n=15 diagnosed with lung cancer, head and neck, renal, bladder and colorectal cancer (n=2, each), and melanoma (n=1). They were treated with Anti PD-1/PDL-1 mono therapy (n=18), combo with chemo (n=2), or combo with anti-CTLA4 (n=2). Three patients had G1 colitis and two, >=G2, all treated with anti-PD1 and before 6th cycle, as described on literature. ROC curve presents AUC 0,559 (CI95%:0,32-0,798) and RR for colitis taking FC value is 1,001 for each 10 units (p=0,493).   Conclusion: Even though we must take into account the limitations of the study we cannot conclude that FC could be used as a predictor for detecting immune-mediated colitis.

scholarly journals Effects of Psychiatric Comorbidity in Immune-Mediated Inflammatory Disease: Protocol for a Prospective Study

2018 ◽  
Vol 7 (1) ◽  
pp. e15 ◽  
Author(s):  
Ruth Ann Marrie ◽  
Lesley Graff ◽  
John R Walker ◽  
John D Fisk ◽  
Scott B Patten ◽  
...  
Keyword(s):  
Prospective Study ◽  
Inflammatory Disease ◽  
Psychiatric Comorbidity ◽  
Immune Mediated ◽  
A Prospective Study

scholarly journals Effects of Psychiatric Comorbidity in Immune-Mediated Inflammatory Disease: Protocol for a Prospective Study (Preprint)

2017 ◽  
Author(s):  
Ruth Ann Marrie ◽  
Lesley Graff ◽  
John R Walker ◽  
John D Fisk ◽  
Scott B Patten ◽  
...  
Keyword(s):  
Psychiatric Comorbidity ◽  
Inflammatory Diseases ◽  
The United States ◽  
Depression And Anxiety ◽  
Case Identification ◽  
Immune Mediated ◽  
Final Study ◽  
Related Quality ◽  
Health Related ◽  
A Prospective Study

BACKGROUND Immune-mediated inflammatory diseases (IMID), such as inflammatory bowel disease (IBD), multiple sclerosis (MS), and rheumatoid arthritis (RA), are highly prevalent in Canada and the United States and result in substantial personal and societal burden. The prevalence of psychiatric comorbidities, primarily depression and anxiety, in IMID exceeds those in the general population by two- to threefold, but remains underdiagnosed and undertreated. Furthermore, the effects of psychiatric comorbidity on IMID are not well understood. OBJECTIVE The objectives of this study were (1) to compare health-related quality of life and work ability in persons with IMID and psychiatric comorbidity with those of persons with IMID without psychiatric comorbidity and with those of persons with depression and anxiety disorders alone, and (2) to validate existing case identification tools for depression and anxiety in persons with IMID to facilitate improved identification of depression and anxiety by clinicians. To achieve these objectives, we designed a prospective 3-year longitudinal study. In this paper, we aim to describe the study rationale and design and the characteristics of study participants. METHODS Between November 2014 and July 2016, we recruited 982 individuals from multiple clinic and community sources; 18 were withdrawn due to protocol violations. RESULTS The final study sample included 247 participants with IBD, 255 with MS, 154 with RA, and 308 with depression or anxiety. The majority were white, with the proportion ranging from 85.4% (IBD [210/246]; MS [217/254]) to 74.5% (114/153, RA; P=.01). There was a female predominance in all groups, which was highest in the RA cohort (84.4%, 130/154) and least marked in the IBD cohort (62.7%, 155/247). Participants with depression or anxiety were more likely to be single (36.0%, 111/308) than participants in any other group (11.8% [30/255]-22.7% [56/247], P<.001). CONCLUSIONS This paper presents the rationale for this study, describes study procedures, and characterizes the cohort enrolled. Ultimately, the aim is improved care for individuals affected by IMID.

Anxiety, depression and stressful life events among medical students: a prospective study in Antalya, Turkey

2001 ◽  
Vol 35 (1) ◽  
pp. 12-17 ◽  
Author(s):  
Mehmet Aktekin ◽  
Taha Karaman ◽  
Yesim Yigiter Senol ◽  
Sukru Erdem ◽  
Hakan Erengin ◽  
...  
Keyword(s):  
Medical Students ◽  
Prospective Study ◽  
Life Events ◽  
Stressful Life Events ◽  
Stressful Life ◽  
A Prospective Study ◽  
Anxiety Depression
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